{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:45:40Z","timestamp":1774125940418,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1067\/mai.2001.119158","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T18:14:26Z","timestamp":1030212866000},"page":"772-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q"],"prefix":"10.1067","volume":"108","author":[{"given":"Catharine J.","family":"Holberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Halonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope E.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2001.119158_bib1","first-page":"143","article-title":"Genetic analysis of complex phenotypes: family studies of total IgE levels and bronchial hyperreactivity","author":"Elston","year":"1993"},{"key":"10.1067\/mai.2001.119158_bib2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1164\/ajrccm.153.6.8665031","article-title":"The genetics of asthma","volume":"153","author":"Sandford","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng0497-389","article-title":"A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CGSA)","volume":"15","author":"The Collaborative Study on the Genetics of Asthma (CGSA)","year":"1997","journal-title":"Nat Genet"},{"issue":"Suppl 6","key":"10.1067\/mai.2001.119158_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1289\/ehp.95103s6229","article-title":"Basic mechanisms of asthma","volume":"106","author":"Boushey","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1067\/mai.2001.119158_bib5","series-title":"Expert panel report 2: guidelines for the diagnosis and management of asthma","author":"National Asthma Education and Prevention Program","year":"1997"},{"key":"10.1067\/mai.2001.119158_bib6","series-title":"NHLBI\/WHO Workshop Report","author":"National Institutes of Health","year":"1993"},{"key":"10.1067\/mai.2001.119158_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1164\/ajrccm\/136.1.225","article-title":"Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease","volume":"136","author":"American Thoracic Society","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119158_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2001.119158_bib9","series-title":"Epidemiologic aspects","author":"Gregg","year":"1983"},{"issue":"Suppl 6","key":"10.1067\/mai.2001.119158_bib10","first-page":"74S-8S","article-title":"Epidemiologic approaches to the identification of asthma","volume":"91","author":"Samet","year":"1987","journal-title":"Chest"},{"issue":"Suppl","key":"10.1067\/mai.2001.119158_bib11","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1164\/ajrccm.156.4.12tac-8","article-title":"Complexities of the genetics of asthma","volume":"156","author":"Martinez","year":"1997","journal-title":"Am Rev Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib12","first-page":"L157","article-title":"A genetic approach to the study of lung physiology: understanding biological variability in airways repsonsiveness","volume":"258","author":"Levitt","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2001.119158_bib13","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0140-6736(89)92687-1","article-title":"Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q","volume":"1","author":"Cookson","year":"1989","journal-title":"Lancet"},{"key":"10.1067\/mai.2001.119158_bib14","first-page":"321","article-title":"General discussion and summing-up","author":"Marsh","year":"1993"},{"key":"10.1067\/mai.2001.119158_bib15","first-page":"555","article-title":"Evidence for Mendelian inheritance of serum IgE levels in Hispanic and non-Hispanic white families","volume":"55","author":"Martinez","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1067\/mai.2001.119158_bib16","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/01688639708403757","article-title":"Confirmatory factor analysis of the Wechsler Memory Scale-revised in a sample of clients with alcohol dependency","volume":"19","author":"Bowden","year":"1997","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1067\/mai.2001.119158_bib17","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/oxfordjournals.aje.a115242","article-title":"The Tucson Children's Respiratory Study. I. Design and implementation of a prospective study of acute and chronic respiratory illness in children","volume":"129","author":"Taussig","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1067\/mai.2001.119158_bib18","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1164\/ajrccm.158.6.9712040","article-title":"Linkage of circulating eosinophils to markers in chromosome 5q","volume":"158","author":"Martinez","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1542\/peds.94.6.895","article-title":"Epidemiology of physician-diagnosed allergic rhinitis in childhood","volume":"94","author":"Wright","year":"1994","journal-title":"Pediatrics"},{"key":"10.1067\/mai.2001.119158_bib20","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1164\/ajrccm.153.4.8616551","article-title":"Recurrent cough in childhood and its relation to asthma","volume":"153","author":"Wright","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2001.119158_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1542\/peds.89.1.21","article-title":"Increased incidence of asthma in children of smoking mothers","volume":"89","author":"Martinez","year":"1992","journal-title":"Pediatrics"},{"key":"10.1067\/mai.2001.119158_bib23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/ajrccm\/146.4.866","article-title":"The predictive relationship between serum IgE levels at birth and subsequent incidences of lower respiratory illnesses and eczema in infants","volume":"146","author":"Halonen","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119158_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJM198902023200502","article-title":"Association of asthma with serum IgE levels and skin test reactivity to allergens","volume":"320","author":"Burrows","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2001.119158_bib25","first-page":"152","article-title":"Respiratory Disease in a New Mexico population sample of Hispanic and non-Hispanic whites","volume":"125","author":"Samet","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119158_bib26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0091-6749(99)70110-7","article-title":"Total serum IgE and its association with asthma symptoms and allergic sensitization among children","volume":"104","author":"Sherrill","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119158_bib27","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/oxfordjournals.aje.a009748","article-title":"Influence of parental smoking on respiratory symptoms during the first decade of life","volume":"149","author":"Stein","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1067\/mai.2001.119158_bib28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1378\/chest.84.5.587","article-title":"A comparison of the respiratory health of Mexican-American and non-Mexican-American white children","volume":"84","author":"Dodge","year":"1983","journal-title":"Chest"},{"key":"10.1067\/mai.2001.119158_bib29","series-title":"S.A.G.E. Statistical Analysis for Genetic Epidemiology","year":"1997"},{"key":"10.1067\/mai.2001.119158_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01066731","article-title":"The investigation of linkage between a quantitative trait and a marker locus","volume":"2","author":"Haseman","year":"1972","journal-title":"Behav Genet"},{"key":"10.1067\/mai.2001.119158_bib31","first-page":"201","article-title":"Power of the sib-pair and lod score methods for linkage analysis of quantitative traits","volume":"329","author":"Demenais","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"10.1067\/mai.2001.119158_bib32","first-page":"439","article-title":"Complete multipoint sib-pair analysis of qualitative and quantitative traits","volume":"57","author":"Kruglyak","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1067\/mai.2001.119158_bib33","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1067\/mai.2001.119158_bib34","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.7777857","article-title":"Extreme discordant sib pairs for mapping quantitative trait loci in humans","volume":"268","author":"Risch","year":"1995","journal-title":"Science"},{"key":"10.1067\/mai.2001.119158_bib35","series-title":"Factor analysis. Statistical Package for the Social Sciences","author":"Kim","year":"1975"},{"key":"10.1067\/mai.2001.119158_bib36","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1164\/ajrccm.155.4.9105079","article-title":"Alternaria as a major allergen for asthma in children raised in a desert environment","volume":"155","author":"Halonen","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib37","series-title":"Introduction to quantitative genetics","author":"Falconer","year":"1996"},{"key":"10.1067\/mai.2001.119158_bib38","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4269\/ajtmh.1998.58.705","article-title":"Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31-33 chromosome region","volume":"58","author":"Garcia","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"10.1067\/mai.2001.119158_bib39","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1056\/NEJM199510053331402","article-title":"Genetic susceptibility to asthma\u2014bronchial hyperresponsiveness coinherited with a major gene for atopy","volume":"333","author":"Postma","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2001.119158_bib40","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0140-6736(00)02842-7","article-title":"Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study group","volume":"356","author":"Lau","year":"2000","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1067\/mai.2001.119158_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1469-1809.1994.tb00732.x","article-title":"Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies","volume":"58","author":"Lawrence","year":"1994","journal-title":"Ann Hum Genet"},{"issue":"Suppl 1","key":"10.1067\/mai.2001.119158_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2222.1998.0280s1095.x","article-title":"Quantitative scores for asthma and atopy","volume":"28","author":"Morton","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2001.119158_bib43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/geno.1998.5485","article-title":"Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores","volume":"53","author":"Wilkinson","year":"1998","journal-title":"Genomics"},{"key":"10.1067\/mai.2001.119158_bib44","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.8178175","article-title":"Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations","volume":"264","author":"Marsh","year":"1994","journal-title":"Science"},{"key":"10.1067\/mai.2001.119158_bib45","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/geno.1994.1524","article-title":"Evidence for a locus regulating total serum IgE levels mapping to chromosome 5","volume":"23","author":"Meyers","year":"1994","journal-title":"Genomics"},{"key":"10.1067\/mai.2001.119158_bib46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ajmg.1320100304","article-title":"Genetic transmission of serum IgE levels","volume":"10","author":"Blumenthal","year":"1981","journal-title":"Am J Med Genet"},{"key":"10.1067\/mai.2001.119158_bib47","first-page":"46","article-title":"A genetic study of IgE","volume":"30","author":"Gerrard","year":"1978","journal-title":"Am J Hum Genet"},{"key":"10.1067\/mai.2001.119158_bib48","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1164\/ajrccm.161.6.9805104","article-title":"Independent inheritance of serum immunolglobulin E concentrations and airway responsiveness","volume":"161","author":"Palmer","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0091-6749(84)80018-4","article-title":"Genetic analysis of allergic disease in twins","volume":"73","author":"Hopp","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119158_bib50","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1399-0004.1996.tb02384.x","article-title":"Cord blood immunoglobulin E in like-sexed momzygotic and dizygotic twins","volume":"50","author":"Husby","year":"1996","journal-title":"Clin Genet"},{"key":"10.1067\/mai.2001.119158_bib51","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1172\/JCI117850","article-title":"Human eosinophil granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation","volume":"95","author":"Coyle","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.119158_bib52","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0091-6749(97)70276-8","article-title":"The relative contribution of IL4 and IL13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells","volume":"100","author":"Punnonen","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119158_bib53","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1164\/ajrccm.156.5.9702084","article-title":"Evidence for linkage between asthma\/atopy in childhood and chromosome 5q31-33 in a Japanese population","volume":"156","author":"Noguchi","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib54","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0091-6749(98)70134-4","article-title":"Genetic influences of chromosomes 5q31-33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families. Collaborative Study on the Genetics of Asthma","volume":"102","author":"Hizawa","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119158_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng1096-181","article-title":"Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33","volume":"14","author":"Marquet","year":"1996","journal-title":"Nat Genet"},{"key":"10.1067\/mai.2001.119158_bib56","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1086\/302053","article-title":"Familial eosinophilia maps to the cytokine gene cluster on human chromosome region 5q31-33","volume":"63","author":"Rioux","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1067\/mai.2001.119158_bib57","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/hmg\/6.12.2069","article-title":"Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population","volume":"6","author":"Laitinen","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1067\/mai.2001.119158_bib58","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2222.1998.00256.x","article-title":"Association of asthma and the interleukin-4 promoter gene in Japanese","volume":"28","author":"Noguchi","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2001.119158_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2222.1998.00229.x","article-title":"Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers","volume":"28","author":"Mansur","year":"1998","journal-title":"Clin Exp Allergy"},{"issue":"Suppl","key":"10.1067\/mai.2001.119158_bib60","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1164\/ajrccm.156.4.12tac-15","article-title":"Polymorphisms of the beta2-adrenergic receptor and asthma","volume":"156","author":"Liggett","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib61","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1172\/JCI119874","article-title":"Association between genetic polymorphisms of the b2-Adrenoceptor and response to albuterol in children with and without a history of wheezing","volume":"100","author":"Martinez","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.119158_bib62","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","article-title":"A polymorphism in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E","volume":"20","author":"Baldini","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2001.119158_bib63","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1164\/ajrccm.153.4.8616554","article-title":"Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness","volume":"153","author":"Doull","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119158_bib64","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1067\/mai.2000.104940","article-title":"A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of Caucasian children","volume":"105","author":"Graves","year":"2000","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901121573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901121573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:47:34Z","timestamp":1758775654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674901121573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0091674901121573"],"URL":"https:\/\/doi.org\/10.1067\/mai.2001.119158","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2001.119158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}