{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:01:54Z","timestamp":1791140514297,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1067\/mai.2001.119411","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T18:14:26Z","timestamp":1030212866000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":179,"title":["Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma"],"prefix":"10.1067","volume":"108","author":[{"given":"Prescott G.","family":"Woodruff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Khashayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Janson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homer A.","family":"Boushey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Fahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2001.119411_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"New Engl J Med"},{"key":"10.1067\/mai.2001.119411_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1164\/ajrccm\/142.2.434","article-title":"Mucosal inflammation in asthma","volume":"142","author":"Djukanovic","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119411_bib3","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1172\/JCI117118","article-title":"Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways","volume":"93","author":"Montefort","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.119411_bib4","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1164\/ajrccm\/147.5.1126","article-title":"Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects","volume":"147","author":"Fahy","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119411_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1164\/ajrccm.154.2.8756799","article-title":"Indices of airway inflammation in induced sputum: reproducibility and viability of cell and fluid-phase measurements","volume":"154","author":"Pizzichini","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1164\/ajrccm.152.1.7599862","article-title":"Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects","volume":"152","author":"Fahy","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib7","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry: 1994 update","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general US population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0091-6749(75)90107-4","article-title":"Standardization of bronchial inhalation challenge procedures","volume":"56","author":"Chai","year":"1975","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119411_bib10","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1183\/09031936.96.09122448","article-title":"Comparison of two methods of collecting induced sputum in asthmatic subjects","volume":"9","author":"Gershman","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1067\/mai.2001.119411_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1164\/ajrccm.161.2.9903097","article-title":"Induced sputum cell counts in healthy adults","volume":"161","author":"Belda","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib12","first-page":"286","article-title":"Eosinophils in asthma","volume":"68","author":"Busse","year":"1992","journal-title":"Ann Allergy"},{"key":"10.1067\/mai.2001.119411_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0091-6749(95)70128-1","article-title":"Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation","volume":"95","author":"Fahy","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2001.119411_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/ajrccm.157.2.97-02099","article-title":"Bronchial neutrophilia in patients with noninfectious status asthmaticus","volume":"157","author":"Lamblin","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1164\/ajrccm\/148.3.713","article-title":"Sudden onset fatal asthma: a distinct clinical entity with few eosinophils and relatively more neutrophils in the airway submucosa?","volume":"148","author":"Sur","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119411_bib16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/ajrccm.161.4.9812061","article-title":"Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: clinical and biologic significance","volume":"161","author":"Ordonez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1164\/ajrccm.156.3.9610046","article-title":"Bronchoscopic evaluation of severe asthma","volume":"156","author":"Wenzel","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib18","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1164\/ajrccm.160.5.9806170","article-title":"Neutrophilic inflammation in severe persistent asthma","volume":"160","author":"Jatakanon","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1164\/ajrccm.161.1.9802048","article-title":"The relationship between airways inflammation and asthma severity","volume":"161","author":"Louis","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2001.119411_bib20","first-page":"L294","article-title":"Neutrophil dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules","volume":"275","author":"Takeyama","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2001.119411_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1034\/j.1399-3003.1999.13a35.x","article-title":"Role of neutrophil elastase in hypersecretion from asthma","volume":"13","author":"Nadel","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1067\/mai.2001.119411_bib22","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1172\/JCI114492","article-title":"Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway serous glands","volume":"85","author":"Sommerhoff","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2001.119411_bib23","first-page":"26","article-title":"Effects of human neutrophil elastase and Pseudomnas aeruginosa proteinases on human respiratory epithelium","volume":"1","author":"Amitani","year":"1991","journal-title":"Am J Respir Crit Care Med"},{"issue":"1 pt 1","key":"10.1067\/mai.2001.119411_bib24","first-page":"L28","article-title":"Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro","volume":"276","author":"Liu","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2001.119411_bib25","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1183\/09031936.96.09122441","article-title":"Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma","volume":"9","author":"in't Veen","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1067\/mai.2001.119411_bib26","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1365-2222.1997.tb01150.x","article-title":"Induced sputum to assess airway inflammation: a study of reproducibility","volume":"27","author":"Spanevello","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2001.119411_bib27","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1164\/ajrccm\/145.6.1265","article-title":"Use of induced sputum cell counts to investigate airway inflammation in asthma","volume":"145","author":"Pin","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2001.119411_bib28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1056\/NEJM199810223391703","article-title":"A 15-year follow-up study of ventilatory function in adults with asthma","volume":"339","author":"Lange","year":"1998","journal-title":"N Engl J Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901171368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674901171368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:47:18Z","timestamp":1758775638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674901171368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0091674901171368"],"URL":"https:\/\/doi.org\/10.1067\/mai.2001.119411","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2001.119411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}