{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:15:23Z","timestamp":1790471723030,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1067\/mai.2002.121454","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T22:14:26Z","timestamp":1030227266000},"page":"287-293","source":"Crossref","is-referenced-by-count":62,"title":["Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils"],"prefix":"10.1067","volume":"109","author":[{"given":"Barbara","family":"Foster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Devouassoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calman","family":"Prussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2002.121454_bib1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/intimm\/8.8.1287","article-title":"IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type","volume":"8","author":"Kasaian","year":"1996","journal-title":"Int Immunol"},{"key":"10.1067\/mai.2002.121454_bib2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0091-6749(99)70292-7","article-title":"Frequency and characterization of antigen-specific IL-4- and IL-13- producing basophils and T cells in peripheral blood of healthy and asthmatic subjects","volume":"104","author":"Devouassoux","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.121454_bib3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0091-6749(98)70248-9","article-title":"Immunohistochemical detection of human basophils in late-phase skin reactions","volume":"101","author":"Irani","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.121454_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0091-6749(00)90184-2","article-title":"Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin","volume":"105","author":"Macfarlane","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.121454_bib5","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1164\/ajrccm.161.5.9908090","article-title":"Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics","volume":"161","author":"Gauvreau","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.121454_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0091-6749(97)70065-4","article-title":"New concepts: the basophil","volume":"99","author":"Schroeder","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.121454_bib7","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1182\/blood.V96.13.4028","article-title":"The human basophil: a new appreciation of its role in immune responses","volume":"96","author":"Falcone","year":"2000","journal-title":"Blood"},{"key":"10.1067\/mai.2002.121454_bib8","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.4049\/jimmunol.138.7.2184","article-title":"Evaluation of human peripheral blood leukocytes for mast cell tryptase","volume":"138","author":"Castells","year":"1987","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1164\/ajrccm\/137.5.1002","article-title":"Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma","volume":"137","author":"Wenzel","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2002.121454_bib10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1365-2222.1998.00228.x","article-title":"Histamine release from bronchoalveolar lavage cells from asthmatic subjects after allergen challenge and relationship to the late asthmatic response","volume":"28","author":"Heaney","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.121454_bib11","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.160.4.1910","article-title":"Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6","volume":"160","author":"Huang","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib12","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.158.5.2310","article-title":"Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis","volume":"158","author":"Gruber","year":"1997","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib13","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI119290","article-title":"Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts","volume":"99","author":"Cairns","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.121454_bib14","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.4049\/jimmunol.161.9.5079","article-title":"Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients","volume":"161","author":"Li","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib15","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1182\/blood.V97.11.3484","article-title":"Mast cells\/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4","volume":"97","author":"Li","year":"2001","journal-title":"Blood"},{"key":"10.1067\/mai.2002.121454_bib16","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1177\/37.10.2674273","article-title":"Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies","volume":"37","author":"Irani","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1067\/mai.2002.121454_bib17","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.4049\/jimmunol.154.12.6548","article-title":"Identification and partial characterization of a unique marker for human basophils","volume":"154","author":"Kepley","year":"1995","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib18","first-page":"27","article-title":"Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation","volume":"79","author":"McEuen","year":"1999","journal-title":"Lab Invest"},{"key":"10.1067\/mai.2002.121454_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1164\/ajrccm\/136.1.225","volume":"136","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2002.121454_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0022-1759(95)00209-X","article-title":"Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies","volume":"188","author":"Prussin","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1067\/mai.2002.121454_bib21","first-page":"6.24.1","article-title":"Detection of intracellular cytokines by flow cytometry","author":"Prussin","year":"1998"},{"key":"10.1067\/mai.2002.121454_bib22","first-page":"1.3.1","article-title":"Standardization, calibration, and control in flow cytometry","author":"Hoffman","year":"1997"},{"key":"10.1067\/mai.2002.121454_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.1993.tb38760.x","article-title":"Development of clinical standards for flow cytometry","volume":"677","author":"Schwartz","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"10.1067\/mai.2002.121454_bib24","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1172\/JCI118337","article-title":"The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis","volume":"96","author":"Schwartz","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.121454_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0022-1759(89)90102-6","article-title":"Flow cytometric methods for the analysis of human basophil surface antigens and viability","volume":"125","author":"Bochner","year":"1989","journal-title":"J Immunol Methods"},{"key":"10.1067\/mai.2002.121454_bib26","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.4049\/jimmunol.163.5.2877","article-title":"Eotaxin potentiates antigen-dependent basophil IL-4 production","volume":"163","author":"Devouassoux","year":"1999","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.121454_bib27","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1182\/blood.V84.8.2489.2489","article-title":"Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+\/Fc epsilon RI-cell population","volume":"84","author":"Rottem","year":"1994","journal-title":"Blood"},{"key":"10.1067\/mai.2002.121454_bib28","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1056\/NEJM198706253162603","article-title":"Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis","volume":"316","author":"Schwartz","year":"1987","journal-title":"N Engl J Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902664127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902664127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:42:58Z","timestamp":1680532978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674902664127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S0091674902664127"],"URL":"https:\/\/doi.org\/10.1067\/mai.2002.121454","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}