{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:56:13Z","timestamp":1792760173208,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1067\/mai.2002.123236","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T22:14:26Z","timestamp":1030227266000},"page":"694-700","source":"Crossref","is-referenced-by-count":235,"title":["TH1\/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced late-phase cutaneous reaction"],"prefix":"10.1067","volume":"109","author":[{"given":"Sun","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Barry","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen P.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2002.123236_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0091-6749(83)90096-9","article-title":"Histologic studies of chronic idiopathic urticaria","volume":"71","author":"Natbony","year":"1983","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/0091-6749(86)90240-X","article-title":"Studies of cellular infiltrate of chronic idiopathic urticaria: prominence of T-lymphocytes, monocytes, and mast cells","volume":"78","author":"Elias","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0091-6749(99)70475-6","article-title":"Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-Fc\u03b5RI or anti IgE autoantibodies","volume":"103","author":"Sabroe","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib4","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.4049\/jimmunol.141.12.4158","article-title":"The relationship between CD4+ lymphocytes, activated eosinophils and magnitude of the allergen-induced late phase skin reaction in man","volume":"141","author":"Frew","year":"1988","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.123236_bib5","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.4049\/jimmunol.163.7.3976","volume":"163","author":"Ying","year":"1999","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.123236_bib6","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1056\/NEJM199306033282204","article-title":"Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria","volume":"328","author":"Hide","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2002.123236_bib7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/1523-1747.ep12338544","article-title":"Dermal mast cell activation by autoantibodies against the high affinity IgE receptor in chronic urticaria","volume":"106","author":"Niimi","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mai.2002.123236_bib8","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1172\/JCI118325","article-title":"Serum IgG autoantibodies directed against the \u03b1 chain of Fc\u03b5RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?","volume":"96","author":"Fiebiger","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123236_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0091-6749(97)70071-X","article-title":"Assessment of autoimmunity in patients with chronic urticaria","volume":"99","author":"Tong","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1365-2222.1991.tb03198.x","article-title":"Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria","volume":"21","author":"Grattan","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.123236_bib11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1046\/j.1365-2222.2001.01131.x","article-title":"Chronic urticaria: novel clinical and serological aspects","volume":"31","author":"Asero","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.123236_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0091-6749(99)70129-6","article-title":"Complement dependence of histamine release in chronic urticaria","volume":"104","author":"Ferrer","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1067\/mai.2001.115484","article-title":"Mechanisms of autoimmune activation of basophils in chronic urticaria","volume":"107","author":"Kikuchi","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1067\/mai.2002.120954","article-title":"A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria","volume":"109","author":"Kikuchi","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib15","first-page":"659","article-title":"Co-expression of CD25 and CD3 in atopic allergy and asthma","volume":"75","author":"Hamid","year":"1992","journal-title":"Immunology"},{"key":"10.1067\/mai.2002.123236_bib16","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.4049\/jimmunol.158.7.3539","article-title":"Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics","volume":"158","author":"Ying","year":"1997","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.123236_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1165\/ajrcmb.12.5.7742012","article-title":"Phenotype of cells expressing mRNA for TH2-type (IL-4 and IL-5) and TH1-type (IL-2 and IFN-\u03b3) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatics and normal control subjects","volume":"12","author":"Ying","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2002.123236_bib18","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0091-6749(96)70205-1","article-title":"Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocyte and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-\u03b3","volume":"97","author":"Durham","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.173.3.775","article-title":"Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte\/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects","volume":"173","author":"Kay","year":"1991","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2002.123236_bib20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/1521-4141(200103)31:3<907::AID-IMMU907>3.0.CO;2-1","article-title":"Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals","volume":"31","author":"Tejada-Simon","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2002.123236_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1172\/JCI200113032","article-title":"A virus-induced molecular mimicry model of multiple sclerosis","volume":"108","author":"Olson","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123236_bib22","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/PL00000715","article-title":"Current cases in which epitope mimicry is considered as a component case of autoimmune disease: immune-mediated (type 1) diabetes","volume":"57","author":"Kukreja","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"10.1067\/mai.2002.123236_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1471-4906(00)01829-9","article-title":"Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases","volume":"22","author":"Gerli","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1067\/mai.2002.123236_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-2478(99)00156-X","article-title":"The pattern of a T(H)1 cytokine in autoimmune thyroiditis","volume":"71","author":"Drugarin","year":"2000","journal-title":"Immunol Lett"},{"key":"10.1067\/mai.2002.123236_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02786470","article-title":"The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy","volume":"20","author":"Singh","year":"1999","journal-title":"Immunol Res"},{"key":"10.1067\/mai.2002.123236_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/thy.1996.6.97","article-title":"Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis, and nonautoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR)","volume":"6","author":"Heuer","year":"1996","journal-title":"Thyroid"},{"key":"10.1067\/mai.2002.123236_bib27","first-page":"413","article-title":"Chronic urticaria and autoimmune thyroid diseases","volume":"122","author":"Collet","year":"1995","journal-title":"Ann Dermatol Venereol"},{"key":"10.1067\/mai.2002.123236_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-4362.1997.00187.x","article-title":"The association of chronic urticaria and angioedema with autoimmune thyroiditis","volume":"36","author":"Turktas","year":"1997","journal-title":"Int J Dermatol"},{"key":"10.1067\/mai.2002.123236_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0091-6749(89)90180-2","article-title":"Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients","volume":"84","author":"Leznoff","year":"1989","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib30","first-page":"286","article-title":"Pathogenesis of chronic urticaria","volume":"4","author":"Kaplan","year":"1999","journal-title":"Can J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib31","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI108405","article-title":"Defective histamine release in chronic urticaria","volume":"57","author":"Kern","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123236_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0091-6749(80)90215-8","article-title":"Skin histamine in chronic urticaria","volume":"65","author":"Phanuphak","year":"1980","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0091-6749(95)70055-2","article-title":"Mast cell number and phenotype in chronic idiopathic urticaria","volume":"96","author":"Smith","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123236_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2133.1991.tb06031.x","article-title":"Increased tryptase levels in suction-blister fluid from patients with urticaria","volume":"125","author":"Deleuran","year":"1991","journal-title":"Br J Dermatol"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902134944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902134944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T15:25:54Z","timestamp":1680535554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674902134944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0091674902134944"],"URL":"https:\/\/doi.org\/10.1067\/mai.2002.123236","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}