{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:30:56Z","timestamp":1788827456287,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1067\/mai.2002.123534","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T18:14:26Z","timestamp":1030212866000},"page":"824-830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps"],"prefix":"10.1067","volume":"109","author":[{"given":"Joaquim","family":"Mullol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C.","family":"Fern\u00e0ndez-Morata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Roca-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pujols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Xaubet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Benitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Picado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2002.123534_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"10.1067\/mai.2002.123534_bib2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1073\/pnas.85.7.2315","article-title":"Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release","volume":"85","author":"Raud","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mai.2002.123534_bib3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible cyclooxygenase may have antiinflammatory properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat Med"},{"key":"10.1067\/mai.2002.123534_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI6899","article-title":"Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2","volume":"10","author":"Morteau","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123534_bib5","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1164\/ajrccm.162.2.9911063","article-title":"Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway responsiveness in allergic mice","volume":"162","author":"Peebles","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib6","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0022-3565(25)31461-8","article-title":"Effect of inhibitors of prostaglandin synthesis and prostaglandins E2 and F2\u03b1 on the immunologic release of mediators of inflammation from actively sensitized guinea-pig lung","volume":"207","author":"Hitchcock","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1067\/mai.2002.123534_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1365-2222.1995.tb01104.x","article-title":"Nasal polyps-a model of chronic respiratory mucosal inflammation","volume":"25","author":"Djukanovic","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.123534_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0091-6749(77)90171-3","article-title":"Nasal polyps in asthma and rhinitis: a review of 6,037 patients","volume":"59","author":"Settipane","year":"1977","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.123534_bib9","first-page":"68","article-title":"Origin and structure of nasal polyps","author":"Larsen","year":"1997"},{"key":"10.1067\/mai.2002.123534_bib10","first-page":"166","article-title":"Eicosanoids from biopsy of normal and polypous nasal mucosa","volume":"34","author":"Baenkler","year":"1996","journal-title":"Rhinology"},{"key":"10.1067\/mai.2002.123534_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0952-3278(97)90556-1","article-title":"Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps","volume":"57","author":"Pinto","year":"1997","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"suppl 2","key":"10.1067\/mai.2002.123534_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000195109","article-title":"The pharmacological control of mediator release from human basophils and mast cells","volume":"50","author":"Peters","year":"1986","journal-title":"Respiration"},{"key":"10.1067\/mai.2002.123534_bib13","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1476-5381.1994.tb17093.x","article-title":"Induction of cyclooxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone","volume":"113","author":"Mitchell","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mai.2002.123534_bib14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/thx.52.11.940","article-title":"Enhanced expression of cyclooxygenase isoenzyme 2 (Cox-2) in asthmatic airways and its cellular distribution in aspirinsensitive asthma","volume":"52","author":"Sousa","year":"1997","journal-title":"Thorax"},{"key":"10.1067\/mai.2002.123534_bib15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI620","article-title":"Over-expression of leukotriene C4 synthase in the bronchial biopsies of aspirin-intolerant asthmatics","volume":"101","author":"Cowburn","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123534_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/00016489950181819","article-title":"Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics","volume":"119","author":"Schmid","year":"1999","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1067\/mai.2002.123534_bib17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1164\/ajrccm.161.2.9902034","article-title":"Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients","volume":"161","author":"Kowalski","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/ajrccm.160.1.9808048","article-title":"Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics","volume":"160","author":"Picado","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1046\/j.1365-2222.2000.00891.x","article-title":"Regulation of cyclooxygenase-1 and -2 in human nasal mucosa. Effects of cytokines and dexamethasone","volume":"30","author":"Fern\u00e0ndez-Morata","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.123534_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/abio.1996.9986","article-title":"The use of reverse transcription-competitive polymerase chain reaction to investigate in vivo regulation of gene expression in small tissue samples","volume":"245","author":"Auboeuf","year":"1997","journal-title":"Anal Biochem"},{"key":"10.1067\/mai.2002.123534_bib21","doi-asserted-by":"crossref","first-page":"11769","DOI":"10.1016\/S0021-9258(17)32638-8","article-title":"Induction of cyclooxygenase-2 by interleukin-1a. Evidence for post-transcriptional regulation","volume":"16","author":"Ristimaki","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1067\/mai.2002.123534_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60430-7","article-title":"Prostaglandin endoperoxide H synthases-1 and -2","volume":"62","author":"Smith","year":"1996","journal-title":"Adv Immunol"},{"key":"10.1067\/mai.2002.123534_bib23","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1006\/abbi.1995.1115","article-title":"Analysis and quantification of splicing variants of TPA-inducible PGHS-1 mRNA in rat tracheal epithelial cells","volume":"316","author":"Kitzler","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1067\/mai.2002.123534_bib24","doi-asserted-by":"crossref","first-page":"C259","DOI":"10.1152\/ajpcell.1996.270.1.C259","article-title":"Transcriptional regulation of endothelial constitutive PGHS-1 expression by phorbol ester","volume":"270","author":"Xu","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1067\/mai.2002.123534_bib25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90126-4","article-title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","volume":"83","author":"Langenbach","year":"1995","journal-title":"Cell"},{"key":"10.1067\/mai.2002.123534_bib26","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","article-title":"NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1067\/mai.2002.123534_bib27","doi-asserted-by":"crossref","first-page":"L593","DOI":"10.1152\/ajplung.2001.280.4.L595","article-title":"Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1 beta in perfused rat lungs","volume":"280","author":"Martin","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1067\/mai.2002.123534_bib28","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/sj.bjp.0702193","article-title":"Role of cyclooxygenase-2 induction in interleukin-1 beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline","volume":"125","author":"Pang","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mai.2002.123534_bib29","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.4049\/jimmunol.161.10.5681","article-title":"Inhibition of MAP kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes","volume":"161","author":"Scherle","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.123534_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/(SICI)1097-4644(20000801)78:2<197::AID-JCB3>3.0.CO;2-C","article-title":"Identification of multiple cis-acting elements mediating the induction of prostaglandin G\/H synthase-2 by phorbol ester in murine osteoblastic cells","volume":"78","author":"Okada","year":"2000","journal-title":"J Cell Biochem"},{"key":"10.1067\/mai.2002.123534_bib31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(97)01362-8","article-title":"Superinduction of Cox-2 mRNA by cycloheximide and interleukin-1b involves increased transcription and correlates with increased NF-kB and JNK activation","volume":"418","author":"Newton","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1067\/mai.2002.123534_bib32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI9956","article-title":"Dehydration activates NF-\u03baB-driven, Cox-2-dependent survival mechanism in renal medullary interstitial cells","volume":"106","author":"Hao","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2002.123534_bib33","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.270.52.31315","article-title":"Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells","volume":"270","author":"Yamamoto","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1067\/mai.2002.123534_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0303-7207(95)03739-X","article-title":"Glucocorticoids stimulate prostaglandin H synthase type-2 (PGHS-2) in the fibroblast cells in human amnion cultures","volume":"117","author":"Economopoulos","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"10.1067\/mai.2002.123534_bib35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/thorax.56.5.351","article-title":"Increased expression of inducible nitric oxide synthase and cyclo-oxygenase in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment","volume":"56","author":"Redington","year":"2001","journal-title":"Thorax"},{"key":"10.1067\/mai.2002.123534_bib36","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1164\/ajrccm.155.1.9001335","article-title":"Prednisone increases PGH-synthase in atopic humans in vivo","volume":"155","author":"Dworski","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib37","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.146.8.2712","article-title":"Regulation of Ig-induced eosinophilic degranulation by adenosine 3\u2032, 5\u2032-cyclin monophosphate","volume":"146","author":"Kita","year":"1991","journal-title":"J Immunol"},{"key":"10.1067\/mai.2002.123534_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1164\/ajrccm.159.1.9804030","article-title":"Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation","volume":"159","author":"Gauvreau","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1164\/ajrccm\/148.1.87","article-title":"Effect of inhaled prostaglandin E2 on allergen-induced asthma","volume":"148","author":"Pavord","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2002.123534_bib40","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1164\/ajrccm.149.5.8173753","article-title":"Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects","volume":"149","author":"Melillo","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.123534_bib41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1164\/ajrccm.153.2.8564100","article-title":"Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 secretion","volume":"153","author":"Sestini","year":"1996","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902962603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902962603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:47:32Z","timestamp":1758775652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674902962603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0091674902962603"],"URL":"https:\/\/doi.org\/10.1067\/mai.2002.123534","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2002.123534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}