{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:01:34Z","timestamp":1790193694690,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1067\/mai.2002.124465","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T17:24:11Z","timestamp":1034184251000},"page":"943-948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Allergen vaccination with a liposome-encapsulated extract of Dermatophagoides pteronyssinus : A randomized, double-blind, placebo-controlled trial in asthmatic patients"],"prefix":"10.1067","volume":"109","author":[{"given":"Antonio","family":"Basomba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Tabar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores Hern\u00e1ndez F.","family":"de Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca E.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remedios","family":"Alamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Olagu\u00edbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Moscoso del","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2002.124465_bib1","first-page":"1","article-title":"WHO Position Paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases","volume":"44","author":"Bousquet","year":"1998","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib2","first-page":"969","article-title":"Is allergen immunotherapy effective in asthma? A meta-analysis of randomised controlled trials","volume":"151","author":"Abramson","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mai.2002.124465_bib3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2002.124465_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1398-9995.1991.tb00603.x","article-title":"Liposomes as vehicle for allergen presentation in the immunotherapy of allergic diseases","volume":"46","author":"Arora","year":"1991","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib5","first-page":"202","article-title":"Use of liposomes for standardized therapeutic allergens","author":"Tran","year":"1994"},{"key":"10.1067\/mai.2002.124465_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0167-5699(90)90034-7","article-title":"Immunological adjuvants: a role for liposomes","volume":"11","author":"Gregoriadis","year":"1990","journal-title":"Immunol Today"},{"key":"10.1067\/mai.2002.124465_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2222.1991.tb00816.x","article-title":"Liposomes as carriers for allergy immunotherapy","volume":"21","author":"Audera","year":"1991","journal-title":"Clin Exp Allergy"},{"issue":"suppl 63","key":"10.1067\/mai.2002.124465_bib8","first-page":"176","article-title":"Humoral and cellular immune responses induced by long-term immunisation with liposome-encapsulated antigens","volume":"55","author":"Moscoso del Prado","year":"2000","journal-title":"Allergy"},{"issue":"suppl 1","key":"10.1067\/mai.2002.124465_bib9","first-page":"12","article-title":"Pharmacokinetics of D. pteronyssinus encapsulated in liposomes","volume":"20","author":"Ram\u00edrez","year":"1990","journal-title":"Clin Exp Allergy"},{"key":"10.1067\/mai.2002.124465_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2165\/00063030-199707010-00007","article-title":"Delivery systems for immunomodulatory proteins and peptides","volume":"7","author":"Anderson","year":"1997","journal-title":"Biodrugs"},{"key":"10.1067\/mai.2002.124465_bib11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1398-9995.1997.tb02157.x","article-title":"A 1-year, placebo-controlled, double-blind house-dust mite immunotherapy study in asthmatic adults","volume":"52","author":"Olsen","year":"1997","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib12","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0091-6749(93)90190-Q","article-title":"A controlled dose response study of immunotherapy with standardized, partially purified extract of house dust mite clinical efficacy and side effects","volume":"91","author":"Haugaard","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.124465_bib13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1398-9995.1997.tb00971.x","article-title":"Immunotherapy with standardized extract of Dermatophagoides pteronyssinus in bronchial asthma: a dose titration study","volume":"52","author":"Olagu\u00edbel","year":"1997","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib14","first-page":"71","article-title":"Cuantificaci\u00f3n de los alergenos Der p I y Der f I de los \u00e1caros y Fel d I de gato mediante un ELISA en fase s\u00f3lida","volume":"5","author":"Ventas","year":"1990","journal-title":"Rev Esp Alergol Inmunol Clin"},{"key":"10.1067\/mai.2002.124465_bib15","first-page":"1","article-title":"Preparation and use of liposomes as models of biological membranes","author":"Bangham","year":"1974"},{"key":"10.1067\/mai.2002.124465_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1398-9995.1993.tb04754.x","article-title":"European Academy of Allergology and Clinical Immunology position paper: immunotherapy","volume":"48","author":"Malling","year":"1993","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib17","first-page":"280","article-title":"Evaluaci\u00f3n de una cartilla de s\u00edntomas y medicaci\u00f3n: consistencia interna y relaci\u00f3n con la valoraci\u00f3n cl\u00ednica del m\u00e9dico y del paciente","volume":"13","author":"Rico","year":"1998","journal-title":"Rev Esp Alergol Inmunol Clin"},{"key":"10.1067\/mai.2002.124465_bib18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00439226","article-title":"Health state valuations from the general public using the visual analogue scale","volume":"5","author":"Gudex","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1067\/mai.2002.124465_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1164\/ajrccm\/143.2.323","article-title":"The normal range of diurnal changes in peak expiratory flow rates. Relationship to symptoms and respiratory disease","volume":"143","author":"Quackenboss","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mai.2002.124465_bib20","first-page":"125","article-title":"Valoraci\u00f3n de la presi\u00f3n alerg\u00e9nica ambiental. Inter\u00e9s de esta determinaci\u00f3n en la prevenci\u00f3n, diagn\u00f3stico y tratamiento de las enfermedades al\u00e9rgicas","volume":"5","author":"Barber","year":"1990","journal-title":"Rev Esp Alergol Immunol Clin"},{"key":"10.1067\/mai.2002.124465_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1398-9995.1997.tb02552.x","article-title":"A computer program based on parallel line assay for analysis of skin tests","volume":"52","author":"Mart\u00edn","year":"1997","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0091-6749(75)90107-4","article-title":"Standardization of bronchial inhalation challenge procedures","volume":"56","author":"Chai","year":"1975","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.124465_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0022-1759(84)90412-5","article-title":"Monoclonal antibodies to three distinct epitopes on human IgE: their use for determination of allergen-specific IgE","volume":"73","author":"S\u00e1nchez-Madrid","year":"1984","journal-title":"J Immunol Methods"},{"key":"10.1067\/mai.2002.124465_bib24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000235210","article-title":"Obtention of monoclonal antibodies against human IgG4 using two different immunization strategies: development of a biotin-based ELISA for IgG4 quantitation","volume":"92","author":"Jimeno","year":"1990","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1067\/mai.2002.124465_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1398-9995.1998.tb04082.x","article-title":"Immunotherapy as an effective tool in allergy treatment","volume":"53","author":"Malling","year":"1998","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib26","first-page":"155","article-title":"Dermatophagoides pteronyssinus cluster immunotherapy. A controlled trial of safety and clinical efficacy","volume":"9","author":"Tabar","year":"1999","journal-title":"J Invest Clin Immunol"},{"key":"10.1067\/mai.2002.124465_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1398-9995.1995.tb01170.x","article-title":"Grass pollen immunotherapy: efficacy and safety during a 4-year follow-up study","volume":"50","author":"Walker","year":"1995","journal-title":"Allergy"},{"key":"10.1067\/mai.2002.124465_bib28","first-page":"146","article-title":"Cluster versus conventional immunotherapy in patients allergic to Dermatophagoides pteronyssinus : a controlled study of in vivo and in vitro parameters","volume":"9","author":"Muro","year":"1999","journal-title":"J Invest Allergol Clin Immunol"},{"key":"10.1067\/mai.2002.124465_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0091-6749(98)70079-X","article-title":"Immunologic changes associated with allergen immunotherapy","volume":"102","author":"Durham","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2002.124465_bib30","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1398-9995.1993.tb00743.x","article-title":"A prospective safety-monitoring study of immunotherapy with biologically standardized extracts","volume":"48","author":"Tabar","year":"1993","journal-title":"Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902000076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902000076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:47:43Z","timestamp":1758775663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674902000076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["S0091674902000076"],"URL":"https:\/\/doi.org\/10.1067\/mai.2002.124465","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allergen vaccination with a liposome-encapsulated extract of Dermatophagoides pteronyssinus : A randomized, double-blind, placebo-controlled trial in asthmatic patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2002.124465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}