{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:31:20Z","timestamp":1777462280661,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1067\/mai.2003.1586","type":"journal-article","created":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T03:18:29Z","timestamp":1059707909000},"page":"37-44","source":"Crossref","is-referenced-by-count":36,"title":["Impact of intranasal budesonide on immune inflammatory responses and epithelial remodeling in chronic upper airway inflammation"],"prefix":"10.1067","volume":"112","author":[{"given":"Claudio","family":"Mastruzzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Roberta","family":"Greco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Provvidenza","family":"Pistorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Trovato","family":"Salinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Jordana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Dolovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u2020Nunzio","family":"Crimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vancheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2003.1586_bib1","first-page":"223","article-title":"Nasal polyposis: a model of chronic airways inflammation","author":"Jordana","year":"2000"},{"key":"10.1067\/mai.2003.1586_bib2","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.4049\/jimmunol.155.6.3234","article-title":"Distinct immunohistochemical localization of interleukin 4 (IL-4) in human inflamed airways tissues: nasal polyps and asthma. IL-4 is localized to eosinophils in vivo and released by peripheral blood eosinophils","volume":"155","author":"Nonaka","year":"1995","journal-title":"J Immunol"},{"key":"10.1067\/mai.2003.1586_bib3","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.180.5.1937","article-title":"The role of transforming growth factor \u03b2 in the generation of suppression: an interaction between CD8+ T and NK cells","volume":"180","author":"Gray","year":"1994","journal-title":"J Exp Med"},{"key":"10.1067\/mai.2003.1586_bib4","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.4049\/jimmunol.160.5.2248","article-title":"Generation of an inhibitory circuit involving CD8+ T cells, IL-2, and NK cell-derived TGF-\u03b2: contrasting effects of anti-CD2 and anti-CD3","volume":"160","author":"Gray","year":"1998","journal-title":"J Immunol"},{"key":"10.1067\/mai.2003.1586_bib5","first-page":"185","article-title":"A randomized controlled trial showing efficacy of once daily intranasal budesonide in nasal polyposis","volume":"38","author":"Filiaci","year":"2000","journal-title":"Rhinology"},{"key":"10.1067\/mai.2003.1586_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2273.1995.tb00007.x","article-title":"Efficacy of topical cortico-steroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide","volume":"20","author":"Lildholdt","year":"1995","journal-title":"Clin Otolaryngol"},{"key":"10.1067\/mai.2003.1586_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2222.1984.tb02203.x","article-title":"Epithelial damage in nasal polyps","volume":"14","author":"Wladislavosky-Waserman","year":"1984","journal-title":"Clin Allergy"},{"key":"10.1067\/mai.2003.1586_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1067\/mai.2002.121703","article-title":"Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome","volume":"109","author":"Rinne","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2003.1586_bib9","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199711133372001","article-title":"Effect of inhaled formoterol and budesonide on exacerbations of asthma","volume":"337","author":"Pauwels","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1067\/mai.2003.1586_bib10","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.4049\/jimmunol.165.7.4040","article-title":"Eosinophilopoiesis in a murine model of allergic airway eosinophilia: involvement of bone marrow IL-5 and IL-5 receptor alpha","volume":"165","author":"Tomaki","year":"2000","journal-title":"J Immunol"},{"key":"10.1067\/mai.2003.1586_bib11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0091-6749(99)70069-2","article-title":"Molecular basis for selective eosinophils traffcking in asthma: a multi-step paradigm","volume":"104","author":"Wardlaw","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2003.1586_bib12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/thx.53.9.753","article-title":"Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time","volume":"53","author":"Faul","year":"1998","journal-title":"Thorax"},{"key":"10.1067\/mai.2003.1586_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2567.2001.01193.x","article-title":"Specificity, restriction and effector mechanisms of immunoregulatory CD8 T cells","volume":"102","author":"Vukmanovic-Stejic","year":"2001","journal-title":"Immunology"},{"key":"10.1067\/mai.2003.1586_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1359-6101(99)00031-3","article-title":"Murine models define the role of TGF-\u03b2 as a master regulator of immune cell function","volume":"11","author":"Letterio","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1067\/mai.2003.1586_bib15","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/eji.1830220833","article-title":"Differential effect of transforming growth factor \u03b2 on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes","volume":"22","author":"Fargeas","year":"1992","journal-title":"Eur J Immunol"},{"key":"10.1067\/mai.2003.1586_bib16","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4049\/jimmunol.151.2.668","article-title":"Differential activation of CD8+ T cells by transforming growth factor-beta 1","volume":"151","author":"Lee","year":"1993","journal-title":"J Immunol"},{"key":"10.1067\/mai.2003.1586_bib17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1165\/ajrcmb.21.2.3576","article-title":"Transforming growth factor-\u03b2 secreted from CD4+ T cells ameliorates antigen-induced eosinophilic inflammation: a novel high-dose tolerance in the trachea","volume":"21","author":"Haneda","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1067\/mai.2003.1586_bib18","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1172\/JCI2480","article-title":"Plasmid DNA encoding transforming growth-factor \u03b21 suppresses chronic disease in a streptococcal cell wall-induced arthritis model","volume":"101","author":"Song","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2003.1586_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1212\/WNL.51.1.289","article-title":"Phase 1 trial of transforming growth factor beta 2 in chronic progressive MS","volume":"51","author":"Calabresi","year":"1998","journal-title":"Neurology"},{"key":"10.1067\/mai.2003.1586_bib20","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI115469","article-title":"Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes","volume":"88","author":"Ayanlar-Batuman","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2003.1586_bib21","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1093\/ndt\/13.10.2450","article-title":"The antiproliferative effect of glucocorticoids: is it related to induction of TGF-\u03b2?","volume":"13","author":"Almawi","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1067\/mai.2003.1586_bib22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI119590","article-title":"Adenovector-mediated gene transfer of active transforming growth factor-beta 1 induces prolonged severe fibrosis in rat lung","volume":"100","author":"Sime","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1067\/mai.2003.1586_bib23","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1073\/pnas.88.15.6642","article-title":"Transforming growth factor \u03b21 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis","volume":"88","author":"Broekelmann","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mai.2003.1586_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0091-6749(06)80008-4","article-title":"A comparative study of the effects of an inhaled corticosteroid, budesonide, and a \u03b22-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double-blind, parallel-group controlled trial","volume":"90","author":"Laitinen","year":"1992","journal-title":"J Allergy Clin Immunol"},{"key":"10.1067\/mai.2003.1586_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/ajrccm.150.1.8025745","article-title":"Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma","volume":"150","author":"Trigg","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl 1","key":"10.1067\/mai.2003.1586_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2222.2000.00095.x","article-title":"Epithelial damage and response","volume":"30","author":"Holgate","year":"2000","journal-title":"Clin Exp Allergy"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490301443X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009167490301443X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T18:31:17Z","timestamp":1682533877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009167490301443X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["S009167490301443X"],"URL":"https:\/\/doi.org\/10.1067\/mai.2003.1586","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}