{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:12:25Z","timestamp":1789776745659,"version":"4.0.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacionline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Allergy and Clinical Immunology"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1067\/mai.2003.58","type":"journal-article","created":{"date-parts":[[2003,4,23]],"date-time":"2003-04-23T20:57:16Z","timestamp":1051131436000},"page":"374-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay"],"prefix":"10.1067","volume":"111","author":[{"given":"Orathai","family":"Jirapongsananuruk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L.","family":"Malech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Kuhns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Niemela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Anderson-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Fleisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mai.2003.58_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005792-200005000-00004","article-title":"Genetic, biochemical, and clinical features of chronic granulomatous disease","volume":"79","author":"Segal","year":"2000","journal-title":"Medicine"},{"key":"10.1067\/mai.2003.58_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-200005000-00003","article-title":"Chronic granulomatous disease: report on a national registry of 368 patients","volume":"79","author":"Winkelstein","year":"2000","journal-title":"Medicine"},{"key":"10.1067\/mai.2003.58_bib3","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(96)90189-0","article-title":"Testing for chronic granulomatous disease","volume":"347","author":"Vowells","year":"1996","journal-title":"Lancet"},{"key":"10.1067\/mai.2003.58_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0022-3476(96)70437-7","article-title":"Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease","volume":"128","author":"Vowells","year":"1996","journal-title":"J Pediatr"},{"key":"10.1067\/mai.2003.58_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000237660","article-title":"Diagnosis and carrier detection of chronic granulomatous disease in five families by flow cytometry","volume":"114","author":"Crockard","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1067\/mai.2003.58_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01963557","article-title":"Diagnosis of chronic granulomatous disease and its mode of inheritance by dihydrorhodamine 123 and flow microcytofluorometry","volume":"150","author":"Roesler","year":"1991","journal-title":"Eur J Pediatr"},{"key":"10.1067\/mai.2003.58_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0022-1759(94)00247-T","article-title":"Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes","volume":"178","author":"Vowells","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1067\/mai.2003.58_bib8","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.145.8.2595","article-title":"Induction of the respiratory burst in HL-60 cells, correlation of function and protein expression","volume":"145","author":"Levy","year":"1990","journal-title":"J Immunol"},{"key":"10.1067\/mai.2003.58_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/clim.2002.5230","article-title":"CYBB mutation analysis in X-linked chronic granulomatous disease","volume":"104","author":"Jirapongsananuruk","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1067\/mai.2003.58_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev.iy.07.040189.001425","article-title":"Molecular genetics of chronic granulomatous disease","volume":"7","author":"Orkin","year":"1989","journal-title":"Ann Rev Immunol"},{"key":"10.1067\/mai.2003.58_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0301-472X(98)00024-1","article-title":"Uncommon missense and splice mutations and resulting biochemical phenotypes inn German patients with X-linked chronic granulomatous disease","volume":"27","author":"Roesler","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1067\/mai.2003.58_bib12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0167-5699(96)30060-1","article-title":"X-CGDbase: a database of X-CGD-causing mutations","volume":"17","author":"Roos","year":"1996","journal-title":"Immunol Today"},{"key":"10.1067\/mai.2003.58_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/bcmd.2000.0347","article-title":"Hematologically important mutations: X-linked chronic granulomatous disease (second update)","volume":"27","author":"Heyworth","year":"2001","journal-title":"Blood Cells Mol Dis"}],"container-title":["Journal of Allergy and Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902913205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091674902913205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:50:44Z","timestamp":1758775844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091674902913205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0091674902913205"],"URL":"https:\/\/doi.org\/10.1067\/mai.2003.58","relation":{},"ISSN":["0091-6749"],"issn-type":[{"value":"0091-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay","name":"articletitle","label":"Article Title"},{"value":"Journal of Allergy and Clinical Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mai.2003.58","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}