{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T23:55:14Z","timestamp":1726098914681},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T00:00:00Z","timestamp":1031702400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2002,9]]},"abstract":"Objectives<\/jats:title>Population differences in the activity of various cytochrome P450 (CYP) enzymes have been demonstrated on the basis of either genetic or environmental determinants. Hispanics are a large demographic group both worldwide and within the United States; hence the possibility of differences in metabolism between one such group\u2014Mexicans\u2014and a European\u2010derived population was determined with respect to CYP2E1 and CYP3A.<\/jats:p><\/jats:sec>Methods<\/jats:title>Young healthy Mexican immigrants living in Los Angeles, Calif, who had maintained a traditional diet were compared with previously and identically studied groups of age\u2010, sex\u2010, and weight\u2010matched European Americans who resided in middle Tennessee and ate a \u201cwestern\u201d diet (15 men and 15 women). In one study carried out in 15 women, the disposition of chlorzoxazone after an oral dose (250 mg) was compared. In the other investigation, all of the 15 subjects were men and received intravenous [15<\/jats:sup>N<\/jats:italic>3<\/jats:sub>]\u2010labeled midazolam (1 mg) and oral midazolam (2 mg) simultaneously to characterize the disposition of benzodiazepine in the two populations.<\/jats:p><\/jats:sec>Results<\/jats:title>Plasma concentration\u2010time profiles of chlorzoxazone and its 6\u2010hydroxy metabolite and the 0\u2010 to 24\u2010hour urinary recovery of the latter were not different between Mexicans and European Americans. This indicates that CYP2E1 activity is similar in the two populations. Similarly, no significant intergroup differences were noted in the plasma concentration\u2010time profiles of midazolam after either intravenous or oral administration. Accordingly, CYP3A does not appear to be different between Mexicans and European Americans.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Similarity in the metabolism of chlorzoxazone between Mexicans and European Americans suggests that the risk associated with CYP2E1\u2010mediated activation of procarcinogens is not different between these two populations. Likewise, the absence of any difference in the disposition of midazolam indicates that, from a pharmacokinetic standpoint, dosages of drugs metabolized by CYP3A need not be different between Mexicans and European Americans.<\/jats:p>Clinical Pharmacology & Therapeutics<\/jats:italic> (2002) 72<\/jats:bold>, 288\u2013293; doi: 10.1067\/mcp.2002.127398<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1067\/mcp.2002.127398","type":"journal-article","created":{"date-parts":[[2002,10,19]],"date-time":"2002-10-19T05:22:23Z","timestamp":1035004943000},"page":"288-293","source":"Crossref","is-referenced-by-count":10,"title":["Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans*"],"prefix":"10.1111","volume":"72","author":[{"given":"Russell A.","family":"Poland","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Research Center on the Psychobiology of Ethnicity, Harbor\u2010UCLA Medical Center Torrance"},{"name":"The Department of Psychiatry, Cedars\u2010Sinai Medical Center Los Angeles"},{"name":"Department of Pharmacology Vanderbilt University Nashville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keh\u2010Ming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Research Center on the Psychobiology of Ethnicity, Harbor\u2010UCLA Medical Center Torrance"},{"name":"The Department of Psychiatry, Cedars\u2010Sinai Medical Center Los Angeles"},{"name":"Department of Pharmacology Vanderbilt University Nashville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenci","family":"Nuccio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Research Center on the Psychobiology of Ethnicity, Harbor\u2010UCLA Medical Center Torrance"},{"name":"The Department of Psychiatry, Cedars\u2010Sinai Medical Center Los Angeles"},{"name":"Department of Pharmacology Vanderbilt University Nashville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant R.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Research Center on the Psychobiology of Ethnicity, Harbor\u2010UCLA Medical Center Torrance"},{"name":"The Department of Psychiatry, Cedars\u2010Sinai Medical Center Los Angeles"},{"name":"Department of Pharmacology Vanderbilt University Nashville"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,11]]},"container-title":["Clinical Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mcp.2002.127398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:07:49Z","timestamp":1700395669000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1067\/mcp.2002.127398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1067\/mcp.2002.127398"],"URL":"https:\/\/doi.org\/10.1067\/mcp.2002.127398","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}