{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:35:53Z","timestamp":1792704953830,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1067\/mhj.2000.107177","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:15:48Z","timestamp":1027556148000},"page":"111-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Heart diseases affecting the liver and liver diseases affecting the heart"],"prefix":"10.1067","volume":"140","author":[{"given":"Jochanan E.","family":"Naschitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Slobodin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elimelech","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Yeshurun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mhj.2000.107177_bib1","first-page":"1431","article-title":"The liver in circulatory failure","author":"Sherlock","year":"1993"},{"key":"10.1067\/mhj.2000.107177_bib2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1001\/archinte.1987.00370070041006","article-title":"Liver function abnormalities in chronic heart failure. Influence of systemic hemodynamics","volume":"147","author":"Kubo","year":"1987","journal-title":"Arch Intern Med"},{"key":"10.1067\/mhj.2000.107177_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01324740","article-title":"Ischemic hepatitis","volume":"24","author":"Bynum","year":"1979","journal-title":"Diag Dis Sci"},{"key":"10.1067\/mhj.2000.107177_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1445-5994.1990.tb00366.x","article-title":"Mortality associated with ischemic hepatitis","volume":"20","author":"Hickmann","year":"1990","journal-title":"Aust N Z J Med"},{"key":"10.1067\/mhj.2000.107177_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00004836-199804000-00007","article-title":"Ischemic hepatitis. Clinical and laboratory observations in 34 patients","volume":"26","author":"Fuchs","year":"1998","journal-title":"J Clin Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib6","first-page":"421","article-title":"Ischemia, congestive heart failure, Budd-Chiari syndrome and veno-occlusive disease","author":"Bacon","year":"1992"},{"key":"10.1067\/mhj.2000.107177_bib7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/000331979004101101","article-title":"Cardiogenic hepatorenal syndrome","volume":"41","author":"Naschitz","year":"1990","journal-title":"Angiology"},{"key":"10.1067\/mhj.2000.107177_bib8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000174199","article-title":"Compensated cardiogenic shock: a subset with damage limited to liver and kidney. The possible salutary effect of low-dose dopamine","volume":"74","author":"Naschitz","year":"1986","journal-title":"Cardiology"},{"key":"10.1067\/mhj.2000.107177_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00004836-199409000-00008","article-title":"Serum lactic dehydrogenase in the differential diagnosis of acute hepatocellular injury","volume":"19","author":"Cassidy","year":"1994","journal-title":"J Clin Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib10","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1152\/ajplegacy.1976.230.5.1394","article-title":"Direct effect of various catecholamines on liver circulation in dogs","volume":"120","author":"Hirsch","year":"1976","journal-title":"Am J Physiol"},{"key":"10.1067\/mhj.2000.107177_bib11","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0735-1097(95)00318-5","article-title":"Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure","volume":"26","author":"Koifman","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mhj.2000.107177_bib12","first-page":"123A","article-title":"N-acetyl-cysteine improves ICG clearance in addition to systemic hemodynamics during severe hepatic (graft) dysfunction [abstract]","volume":"20","author":"Devlin","year":"1994","journal-title":"Hepatology"},{"key":"10.1067\/mhj.2000.107177_bib13","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/0006-2952(89)90130-5","article-title":"Enhancement of acute ethanol hepatotoxicity under conditions of low oxygen supply and ischemia\/reperfusion. The role of oxygen radicals","volume":"38","author":"Younes","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1067\/mhj.2000.107177_bib14","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/00003246-199302001-00011","article-title":"Vasoactive mediators of splanchnic perfusion","volume":"21","author":"Reilly","year":"1993","journal-title":"Crit Care Med"},{"key":"10.1067\/mhj.2000.107177_bib15","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/00003246-199302001-00012","article-title":"Therapeutic potential of intraluminal oxygenation","volume":"21","author":"Haglund","year":"1993","journal-title":"Crit Care Med"},{"key":"10.1067\/mhj.2000.107177_bib16","first-page":"1232","article-title":"Role of thrombosis in the pathogenesis of CLF (cardiac cirrhosis)","volume":"21","author":"Wanless","year":"1995","journal-title":"Hepatology"},{"key":"10.1067\/mhj.2000.107177_bib17","first-page":"1170","article-title":"Cirrhosis of vascular origin","volume":"41","author":"Valla","year":"1991","journal-title":"Rev Prat"},{"key":"10.1067\/mhj.2000.107177_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00004836-198808000-00013","article-title":"Cardiac ascites: a characterization","volume":"10","author":"Runyon","year":"1988","journal-title":"J Clin Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.7326\/0003-4819-117-3-215","article-title":"The serum-ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites","volume":"117","author":"Runyon","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1067\/mhj.2000.107177_bib20","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3109\/00365529609010358","article-title":"Serum\/ascites albumin gradient: its value as a rational approach to the differential diagnosis of ascites","volume":"31","author":"Akriviadis","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(96)90383-9","article-title":"Endomyocardial fibrosis: why is there striking ascites with little or no peripheral edema [letter]?","volume":"347","author":"Freers","year":"1996","journal-title":"Lancet"},{"key":"10.1067\/mhj.2000.107177_bib22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/hep.1840110123","article-title":"Hepatopulmonary syndrome: an evolving perspective in the era of liver transplantation","volume":"11","author":"Krowka","year":"1990","journal-title":"Hepatology"},{"key":"10.1067\/mhj.2000.107177_bib23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1378\/chest.72.3.305","article-title":"Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis","volume":"72","author":"Kennedy","year":"1977","journal-title":"Chest"},{"key":"10.1067\/mhj.2000.107177_bib24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/thx.47.11.897","article-title":"The hepatopulmonary syndrome: a new name, old complexities [editorial]","volume":"47","author":"Rodriguez-Roisin","year":"1992","journal-title":"Thorax"},{"key":"10.1067\/mhj.2000.107177_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4065\/72.1.44","article-title":"Hepatopulmonary syndrome with progressive hypoxemia as an indication for liver transplantation: case reports and literature review","volume":"72","author":"Krowka","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"10.1067\/mhj.2000.107177_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.7326\/0003-4819-122-7-199504010-00008","article-title":"The hepatopulmonary syndrome","volume":"122","author":"Lange","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1067\/mhj.2000.107177_bib27","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0002-9343(77)90161-9","article-title":"Hypoxemia of cirrhosis: detection of abnormal small pulmonary vascular channels by a quantitative radionuclide method","volume":"63","author":"Wolfe","year":"1977","journal-title":"Am J Med"},{"key":"10.1067\/mhj.2000.107177_bib28","first-page":"81","article-title":"Detecting intrapulmonary right-to-left shunt with contrast echocardiography: observations in a patient with diffuse pulmonary arteriovenous fistulas","volume":"51","author":"Shub","year":"1976","journal-title":"Mayo Clin Proc"},{"key":"10.1067\/mhj.2000.107177_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0272-5231(05)70297-5","article-title":"Hepatopulmonary syndrome: a pulmonary complication of venous disease","volume":"17","author":"Castro","year":"1996","journal-title":"Clin Chest Med"},{"key":"10.1067\/mhj.2000.107177_bib30","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1378\/chest.111.5.1236","article-title":"Comparison of transesophageal and transthoracic contrast echocardiography for detection of an intrapulmonary shunt in liver diseases","volume":"111","author":"Vedrinne","year":"1997","journal-title":"Chest"},{"key":"10.1067\/mhj.2000.107177_bib31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1148\/radiology.211.2.r99ma46549","article-title":"Hypoxemia and liver cirrhosis (hepatopulmonary syndrome) in eight patients: comparison of the central and peripheral pulmonary vasculature","volume":"211","author":"Lee","year":"1999","journal-title":"Radiology"},{"key":"10.1067\/mhj.2000.107177_bib32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1183\/09031936.94.07050839","article-title":"Is severe arterial hypoxaemia due to hepatic disease an indication for liver transplantation? A new therapeutic approach","volume":"7","author":"Rodriguex-Roisin","year":"1994","journal-title":"Eur Resp J"},{"key":"10.1067\/mhj.2000.107177_bib33","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1378\/chest.99.4.1027","article-title":"Effects of indomethacin on hepatogenic pulmonary angiodysplasia","volume":"99","author":"Shijo","year":"1991","journal-title":"Chest"},{"key":"10.1067\/mhj.2000.107177_bib34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00004836-199810000-00010","article-title":"Treatment of hepatopulmonary syndrome with Allium sativum L (garlic): a pilot trial","volume":"27","author":"Abrams","year":"1998","journal-title":"J Clin Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.1840210117","article-title":"Failure of hepatopulmonary syndrome to resolve after liver transplantation and successful treatment with embolotherapy","volume":"21","author":"Poterucha","year":"1995","journal-title":"Hepatology"},{"key":"10.1067\/mhj.2000.107177_bib36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1164\/arrd.1983.127.4.437","article-title":"Primary pulmonary hypertension and cirrhosis: are they related?","volume":"127","author":"McDonnell","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1067\/mhj.2000.107177_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0300-5089(21)00640-4","article-title":"Pulmonary arterial hypertension in portal hypertension","volume":"14","author":"Lockhart","year":"1985","journal-title":"Clin Gastroenterol"},{"key":"10.1067\/mhj.2000.107177_bib38","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0735-1097(10)80121-4","article-title":"Association between primary pulmonary hypertension and portal hypertension: analysis of its pathophysiology and clinical, laboratory and hemodynamic manifestations","volume":"17","author":"Robalino","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mhj.2000.107177_bib39","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/00007890-199904270-00001","article-title":"Portopulmonary hypertension and the liver transplantation candidate","volume":"67","author":"Kuo","year":"1999","journal-title":"Transplantation"},{"key":"10.1067\/mhj.2000.107177_bib40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4065\/71.6.543","article-title":"Frequency and clinical implications of increased pulmonary artery pressure in liver transplant patients","volume":"71","author":"Castro","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"10.1067\/mhj.2000.107177_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000542-199301000-00037","article-title":"Pulmonary hypertension and liver transplantation","volume":"78","author":"DeWolf","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1067\/mhj.2000.107177_bib42","first-page":"1387","article-title":"Transplantation of the liver combined with other organs","volume":"45","author":"Johnston","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"10.1067\/mhj.2000.107177_bib43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00007890-199802270-00001","article-title":"Successful use of chronic epoprostenol as a bridge to liver transplantation in severe portopulmonary hypertension","volume":"65","author":"Plotkin","year":"1998","journal-title":"Transplantation"},{"key":"10.1067\/mhj.2000.107177_bib44","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archinte.1988.00380030091018","article-title":"Pericardial effusion and left ventricular dysfunction associated with ascites secondary to hepatic cirrhosis","volume":"148","author":"Ahah","year":"1988","journal-title":"Arch Intern Med"},{"key":"10.1067\/mhj.2000.107177_bib45","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1046\/j.1440-1746.1999.01920.x","article-title":"Cardiopulmonary dysfunction in cirrhosis","volume":"14","author":"Liu","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1067\/mhj.2000.107177_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJM196708172770703","article-title":"Hepatic artery ligation for hepatic hemangiomatosis","volume":"277","author":"Delorimer","year":"1967","journal-title":"N Engl J Med"},{"key":"10.1067\/mhj.2000.107177_bib47","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/archinte.1984.00350180230033","article-title":"High-output heart failure secondary to hepatic arteriovenous microfistulae. Selective arterial embolization treatment","volume":"144","author":"Brohee","year":"1984","journal-title":"Arch Intern Med"},{"key":"10.1067\/mhj.2000.107177_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.CIR.96.1.22","article-title":"Chronic variant of myocarditis associated with hepatitis C virus infection","volume":"96","author":"Okabe","year":"1997","journal-title":"Circulation"},{"key":"10.1067\/mhj.2000.107177_bib49","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/0735-1097(89)90277-5","article-title":"Cardiac complications in acquired immunodeficiency syndrome (AIDS): a review","volume":"13","author":"Acierno","year":"1989","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mhj.2000.107177_bib50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/qjmed\/90.3.161","article-title":"Unusual complications of paracetamol poisoning","volume":"90","author":"Jones","year":"1997","journal-title":"Q J Med"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870300825077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870300825077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:49:22Z","timestamp":1757566162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870300825077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0002870300825077"],"URL":"https:\/\/doi.org\/10.1067\/mhj.2000.107177","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart diseases affecting the liver and liver diseases affecting the heart","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mhj.2000.107177","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}