{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:21:24Z","timestamp":1790918484454,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1067\/mhj.2001.112238","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:18:43Z","timestamp":1027556323000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":228,"title":["Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome"],"prefix":"10.1067","volume":"141","author":[{"given":"Yoichi","family":"Inokubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Fukushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaatsu","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mhj.2001.112238_bib1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1056\/NEJM198405033101801","article-title":"Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death","volume":"310","author":"Davies","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1067\/mhj.2001.112238_bib2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199201233260406","article-title":"The pathogenesis of coronary artery disease and the acute coronary syndromes","volume":"326","author":"Fuster","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1067\/mhj.2001.112238_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","article-title":"Coronary plaque disruption","volume":"92","author":"Falk","year":"1995","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9149(97)00381-0","article-title":"New insights into the pathogenesis and prevention of acute coronary syndromes","volume":"79","author":"Shah","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1067\/mhj.2001.112238_bib5","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/01.CIR.91.11.2844","article-title":"Molecular bases of the acute coronary syndromes","volume":"91","author":"Libby","year":"1995","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.CIR.92.5.1084","article-title":"Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction","volume":"92","author":"Kovanen","year":"1995","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/01.CIR.90.2.775","article-title":"Macrophage infiltration in acute coronary syndromes","volume":"90","author":"Moreno","year":"1994","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib8","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1161\/01.CIR.91.8.2125","article-title":"Identification of 92-kD gelatinase in human coronary atherosclerotic lesions","volume":"91","author":"Brown","year":"1995","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib9","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00041433-199610000-00012","article-title":"Macrophages and atherosclerotic plaque stability","volume":"7","author":"Libby","year":"1996","journal-title":"Curr Opin Lipidol"},{"key":"10.1067\/mhj.2001.112238_bib10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.CIR.97.12.1195","article-title":"Acute coronary syndromes","volume":"97","author":"Theroux","year":"1998","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib11","first-page":"1565","article-title":"Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques","volume":"92","author":"Shah","year":"1995","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_bib12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0735-1097(98)00283-6","article-title":"Mast cell infiltration in acute coronary syndromes: implications for plaque rupture","volume":"32","author":"Kaartinen","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mhj.2001.112238_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0735-1097(98)00250-2","article-title":"Peripheral blood levels of matrix metalloproteinases-2 and -9 are elevated in patients with acute coronary syndromes","volume":"32","author":"Kai","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mhj.2001.112238_bib14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1161\/01.CIR.90.4.1669","article-title":"Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture","volume":"90","author":"Kaartinen","year":"1994","journal-title":"Circulation"},{"key":"10.1067\/mhj.2001.112238_NEWBIB1","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.4049\/jimmunol.157.9.4159","article-title":"TNF-a and IL-1b selectively induce expression of 92-kDa gelatinase by human macrophages","volume":"157","author":"Saren","year":"1996","journal-title":"J Immunol"},{"key":"10.1067\/mhj.2001.112238_bib16","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1073\/pnas.88.18.8154","article-title":"Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization","volume":"88","author":"Henney","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mhj.2001.112238_bib17","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1067\/mhj.2001.112238_bib18","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI114344","article-title":"Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation","volume":"84","author":"Gruber","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1067\/mhj.2001.112238_bib19","doi-asserted-by":"crossref","first-page":"18134","DOI":"10.1016\/S0021-9258(17)32427-4","article-title":"Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase","volume":"27","author":"Saarinen","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1067\/mhj.2001.112238_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0021-9150(95)05520-7","article-title":"Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity","volume":"116","author":"Tyagi","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1067\/mhj.2001.112238_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1749-6632.1994.tb17348.x","article-title":"Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions","volume":"748","author":"Galis","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1067\/mhj.2001.112238_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.RES.77.5.863","article-title":"Matrix metalloproteinases and cardiovascular disease","volume":"77","author":"Dollery","year":"1995","journal-title":"Circ Res"},{"key":"10.1067\/mhj.2001.112238_bib23","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0022-2828(05)82390-9","article-title":"Regulation of collagen degradation in the rat myocardium after infarction","volume":"27","author":"Cleutjens","year":"1995","journal-title":"J Mol Cell Cardiol"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870301220651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870301220651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:49:06Z","timestamp":1757566146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870301220651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0002870301220651"],"URL":"https:\/\/doi.org\/10.1067\/mhj.2001.112238","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mhj.2001.112238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}