{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:48:49Z","timestamp":1792028929941,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>The treatment of extensive floor\u2010of\u2010mouth carcinoma has remained a challenging problem for head and neck surgeons. We have reviewed our experience in the surgical management of floor\u2010of\u2010mouth cancer in an attempt to identify factors influencing survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 144 patients with cancer involving the floor of the mouth were treated between March 1988 and November 1995. A retrospective chart review was conducted that captured information including clinical staging, therapeutic modalities, pathologic findings, and patient follow\u2010up. Factors affecting survival were assessed by non\u2010parametric analysis and analysis of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There was no statistical significance for the effects of vascular invasion (<jats:italic>P<\/jats:italic> = 0.4019), lymphatic invasion (<jats:italic>P<\/jats:italic> = 0.3430), bone invasion (<jats:italic>P<\/jats:italic> = 0.1548), or positive margins (<jats:italic>P<\/jats:italic> = 0.1113) on survival. Extranodal extension and recurrent disease were strongly suggestive of influencing survival but were not statistically significant (<jats:italic>P<\/jats:italic> = 0.0650 and <jats:italic>P<\/jats:italic> = 0.0504, respectively). Nodal disease significantly affected survival (<jats:italic>P<\/jats:italic> = 0.0138) but did not affect recurrence (<jats:italic>P<\/jats:italic> = 0.451). <jats:italic>CONCLUSION<\/jats:italic>: Mean survival for this cohort was 30.6\u00a0months. Positive node status significantly affected mean overall survival in this series, whereas extracapsular disease did not. These data suggest that aggressive surgical management of neck disease is mandated to maximize survival.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2000.102185","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T14:34:23Z","timestamp":1369060463000},"page":"495-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors affecting survival for floor\u2010of\u2010mouth carcinoma"],"prefix":"10.1002","volume":"122","author":[{"given":"Douglas W.","family":"Klotch","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery H. Lee Moffitt Cancer Center University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Muro\u2010Cacho","sequence":"additional","affiliation":[{"name":"Departments of Pathology University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Gal","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199708)19:5<400::AID-HED6>3.0.CO;2-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80337-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890030020004"},{"key":"e_1_2_9_7_1","first-page":"15","article-title":"The incidence of occult metastases for cancer of the oral tongue and floor of mouth: treatment rationale","volume":"7","author":"Teichgraeber JF","year":"1984","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)40379-8"},{"key":"e_1_2_9_9_1","volume-title":"Statistics for the behavioral sciences","author":"Jaccard J","year":"1990"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199111000-00006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150407"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO;2-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00152-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.6.637"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170603"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199709000-00015"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860110057008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800100082012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199709)19:6<500::AID-HED7>3.0.CO;2-2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900020023003"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.102185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2000.102185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.102185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:27Z","timestamp":1760955507000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2000.102185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1067\/mhn.2000.102185"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2000.102185","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}