{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:09:26Z","timestamp":1792300166339,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>The mucociliary system of the upper and lower respiratory tracts is a critical nonspecific pathway for the elimination of bacteria and other particulate matter. The interaction between bacteria and purified mucin of the upper and lower respiratory tracts has been a major focus of our laboratory for the past decade. We have previously demonstrated that nontypable <jats:italic>Haemophilus influenzae<\/jats:italic> and <jats:italic>Moraxella catarrhalis<\/jats:italic> adhere to human purified nasopharyngeal mucin and human middle ear mucin by a very limited number of specific outer membrane proteins. There have been no previous studies on the interaction of <jats:italic>Streptococcus pneumoniae<\/jats:italic> and purified mucin. Such information would be of extreme importance in identifying specific mechanisms of preventing colonization of this important pathogen to nasopharyngeal mucin. Using an overlay technique of purified radiolabeled mucins of the upper and lower respiratory tracts in a solid phase assay with 4 predominant pathogens of the upper and lower respiratory tracts, we found a striking heterogeneity of bacteria\u2010mucin interaction. The implications of these interactions in the development of otitis media, rhinosinusitis, and lower respiratory infections are briefly discussed.<\/jats:p>","DOI":"10.1067\/mhn.2000.102402","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T14:34:23Z","timestamp":1369060463000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bacteria\u2010mucin interaction in the upper aerodigestive tract shows striking heterogeneity: Implications in otitis media, rhinosinusitis, and pneumonia"],"prefix":"10.1002","volume":"122","author":[{"given":"Joel M.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology and Pediatrics School of Medicine and Biomedical Sciences Buffalo New York"},{"name":"Department of Communicative Disorders and Sciences Buffalo New York"},{"name":"State University of New York at Buffalo Division of Infectious Diseases Children's Hospital of Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molakala","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental Medicine Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.7.2485-2492.1995"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.4.1477-1479.1996"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137922"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300519"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.2002-2020.1994"},{"key":"e_1_2_10_7_1","first-page":"175","article-title":"Middle ear mucin glycoprotein: purification and interaction with non\u2010typable Haemophilus influenzae and Moraxella catarrhalis","volume":"116","author":"Reddy MS","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_10_8_1","first-page":"267","article-title":"Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response","volume":"60","author":"Murphy TF.","year":"1996","journal-title":"Microbiol Mol Biol Rev"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90366-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800341"},{"key":"e_1_2_10_11_1","first-page":"403","article-title":"Binding between Pseudomonas aeruginosa adhesins and human salivary, tracheobronchial and nasopharyngeal mucins","volume":"40","author":"Reddy MS.","year":"1996","journal-title":"Biochem Mol Biol Int"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411930040030901"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1997.0140"},{"key":"e_1_2_10_14_1","first-page":"85","article-title":"Effects of adenoidectomy on sinusitis","volume":"51","author":"Takahashi H","year":"1997","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(93)90067-A"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.102402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2000.102402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.102402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:26Z","timestamp":1760955506000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2000.102402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1067\/mhn.2000.102402"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2000.102402","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}