{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:26:49Z","timestamp":1761056809808,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Some patients lack quality autologous tissue for tympanic membrane (TM) grafting. AlloDerm (LifeCell Corp, The Woodlands, TX) is a preserved allograft that has been effective in nonotologic applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>The goal of this study was to investigate AlloDerm in the repair of chronic TM perforations. <jats:italic>METHODS:<\/jats:italic> Ten adult chinchillas underwent a controlled, 2\u2010stage procedure for creation and repair of bilateral TM perforations. Myringoplasties were performed. The control side (left) was repaired with autologous fascia; AlloDerm was used in all right ears. Grafts were assessed at 3 to 8 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Complete TM perforation closure was noted in 9 of 10 (90%) control ears and 8 of 10 (80%) AlloDerm\u2010treated ears. Fascia and AlloDerm integrated consistently with host tissues. No variables demonstrated statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>AlloDerm appeared to be an ideal substitute for grafting of the TM. It was equally effective as fascia. Clinical trials in human beings appear warranted. Potential health care savings are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2000.105920","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"17-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Tympanic Membrane Perforation Repair Using Alloderm"],"prefix":"10.1002","volume":"123","author":[{"suffix":"Jr.","given":"William J.","family":"McFeely","sequence":"first","affiliation":[{"name":"Farmington Hills and Southfield Michigan"},{"name":"Michigan Ear Institute and Providence Hospital Farmington Hills Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis I.","family":"Bojrab","sequence":"additional","affiliation":[{"name":"Farmington Hills and Southfield Michigan"},{"name":"Michigan Ear Institute and Providence Hospital Farmington Hills Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack M.","family":"Kartush","sequence":"additional","affiliation":[{"name":"Farmington Hills and Southfield Michigan"},{"name":"Michigan Ear Institute and Providence Hospital Farmington Hills Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1177\/000348948008900407"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0305-4179(95)93866-I"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1097\/00004630-199703000-00010"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1097\/00004630-199711000-00005"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1097\/00004630-199603000-00006"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1016\/S1090-820X(96)70055-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1097\/00000637-199811000-00009"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_1","DOI":"10.1016\/S0278-2391(98)90805-9"},{"key":"e_1_2_1_10_1","first-page":"14","article-title":"An acellular dermal matrix allograft substitute for palatal donor tissue","volume":"3","author":"Callan D","year":"1997","journal-title":"Postgrad Dentistry"},{"key":"e_1_2_1_11_1","first-page":"14","article-title":"Use of acellular dermal matrix allograft material in dental implant treatment","volume":"1","author":"Callan D","year":"1996","journal-title":"Dental Surg Products"},{"key":"e_1_2_1_12_1","first-page":"201","article-title":"Clinical evaluation of an acellular dermal allograft for increasing the zone of attached gingiva","volume":"8","author":"Shulman J","year":"1996","journal-title":"Practical Periodont Aesthetic Dent"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_1","DOI":"10.1001\/archotol.124.1.73"},{"key":"e_1_2_1_14_1","first-page":"339","volume-title":"Current therapy in otolaryngology\u2010head and neck surgery","author":"Romo T","year":"1998"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_1","DOI":"10.1177\/019459989210600127"},{"key":"e_1_2_1_16_1","first-page":"10","article-title":"Repair of chronic tympanic membrane perforations using epidermal growth factor: Progress toward clinical application","volume":"15","author":"Lee AJ","year":"1994","journal-title":"Am J Otol"},{"doi-asserted-by":"publisher","key":"e_1_2_1_17_1","DOI":"10.1177\/019459989210700509"},{"doi-asserted-by":"publisher","key":"e_1_2_1_18_1","DOI":"10.1016\/S0194-5998(96)70008-6"},{"unstructured":"KartushJKTM patcher: A new device to close tympanic membrane perforations in an office setting.Am J Otol. 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