{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:36Z","timestamp":1761007596242,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>The cytokine growth\u2010related oncogene\u2010\u03b1 (GRO\u2010\u03b1) is a potent mediator of leukocyte recruitment and proliferation in inflammatory diseases. We hypothesized that GRO\u2010\u03b1 is produced in the inflammatory nasal polyp microenvironment. Evaluation of nasal polyps from 27 patients for distribution and content of GRO\u2010\u03b1 antigen, by use of immunohistochemical techniques and ELISA, revealed its presence in all 27 tissue samples. It was found predominantly within the eosinophils and neutrophils, with tissue levels ranging from 34 pg\/mg total protein (TP) to 1746 pg\/mg TP with a mean value of 631 \u00b1 98 pg\/mg TP. Control tissues contained between 82 pg\/mg TP and 316 pg\/mg TP (mean 176 \u00b1 38 pg\/mg TP). These results were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.03). Clinical correlations and statistical comparisons were calculated. These data suggest that GRO\u2010\u03b1 may be an important factor in the recruitment and activation of leukocytes in nasal polyposis, making it a potential target for therapeutic intervention.<\/jats:p>","DOI":"10.1067\/mhn.2000.105924","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Growth\u2010Related Oncogene\u2010\u03b1 Expression in Human Nasal Polyps"],"prefix":"10.1002","volume":"123","author":[{"given":"Adam M.","family":"Klein","sequence":"first","affiliation":[{"name":"Division of Otolaryngology University of Connecticut Health Center Farmington Connecticut"},{"name":"Department of Surgery University of Connecticut Health Center Farmington 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