{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:29:26Z","timestamp":1782239366828,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5844,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>The migratory behavior of acquired cholesteatoma matrices (those arising from the tympanic membrane) has been described previously. This tissue is derived embryologically from the first branchial groove and represents the only migratory epithelium arising from the branchial groove system. If the matrix from a cerebellopontine angle (CPA) epidermoid tumor exhibits migratory behavior similar to that of acquired cholesteatomas, a first branchial groove site of origin for CPA epidermoids would be supported. Intradural CPA epidermoid cells were grown in a\u2014minimum essential medium. The cultures were examined daily, and cell mass migration rates were measured. It was observed that intradural epidermoid tumor matrix harvested from the CPA exhibited migration in vitro. Its migratory properties were indistinguishable from those of acquired cholesteatomas, which are embryologically derived from the first branchial groove. These data support the theory that purely intradural epidermoids are derived from cells of the first branchial groove.<\/jats:p>","DOI":"10.1067\/mhn.2000.107518","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"170-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Migration of Intradural Epidermoid Matrix: Embryologic Implications"],"prefix":"10.1002","volume":"123","author":[{"given":"Stilianos E.","family":"Kountakis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Virginia Medical School Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.Y. Joseph","family":"Chang","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2014Head and Neck Surgery University of Texas\u2014Houston Medical School Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Gormley","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery University of Texas\u2014Houston Medical School Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando R.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology University of Texas\u2014Houston Medical School Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"971","volume-title":"Epidermoid and dermoid tumors: Clinical features and surgical management","author":"Conley Fk.","year":"1996"},{"key":"e_1_2_6_3_1","first-page":"989","article-title":"Cerebellopontine angle epidermoid cysts: A report on 30 cases","volume":"52","author":"Da Souza CE","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_6_4_1","first-page":"358","article-title":"Congenital cholesteatoma of the cerebellopontine angle","volume":"10","author":"Da Souza CE","year":"1989","journal-title":"Am J Otol"},{"key":"e_1_2_6_5_1","first-page":"351","article-title":"Imaging of epidermoid cysts","volume":"10","author":"Tampieri D","year":"1989","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/85.3.485"},{"key":"e_1_2_6_7_1","first-page":"169","article-title":"An epidermoid formation in the developing middle ear: A possible source of cholesteatoma","volume":"15","author":"Michaels L.","year":"1986","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989611500518"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70150-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70100-6"},{"key":"e_1_2_6_11_1","first-page":"140","article-title":"The specific locomotive activity of tympanic membrane and cholesteatoma epithelium in tissue culture","volume":"17","author":"Boxall JD","year":"1988","journal-title":"J Otolaryngol"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.107518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2000.107518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.107518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:48:05Z","timestamp":1760950085000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2000.107518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1067\/mhn.2000.107518"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2000.107518","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}