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We studied apoptosis using in situ end labeling of the 3'\u2010OH ends of fragmented DNA in 5 progressively older, normal, human cricoid cartilage specimens. Results show that apoptosis is a very active process in fetal and neonatal tissue. The process gradually slows with advancing age. In the 4\u2010 and 13\u2010year\u2010old specimens, minimal to no apoptosis was seen. 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