{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:22:33Z","timestamp":1789669353318,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5753,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Evaluation of the proliferation activity of neuromas has a practical meaning when there are doubts about the complete resection of the tumor. Evaluation of the clinical aspects connected with increased proliferation activity may have a much broader application. The aim of this study was to correlate selected clinical and radiologic aspects of vestibular schwannomas with the results of the Ki\u201067 index. The studied group included 23 males and 20 females. Unilateral neuromas were stated in 38 cases (mean age, 52.2 years) and bilateral tumors in 5 cases (mean age, 44.2 years). The immunohisto\u2010chemical tests (Ki\u201067) were performed on the specimens preserved in formalin and stored in paraffin. The Ki\u201067 index was estimated in a semiquantitative study. The mean value of Ki\u201067 index was 1.86%. In case of unilateral neuromas (n = 38), the average Ki\u201067 index was 1.74%. In 5 cases of bilateral tumors, the index amounted to 2.79% (<jats:italic>P<\/jats:italic> = 0.278). No significant correlation was found by comparing the value of the Ki\u201067 index with the age of patients (<jats:italic>P<\/jats:italic> = 0.410: <jats:italic>r<\/jats:italic> = 0.128). Significant differences in the value of the Ki\u201067 index were noted in the subgroups of tumors that were evaluated radiologically as growing and stable. The mean value of Ki\u201067 index was 3.17% in the first subgroup; in stable neuromas, it was significantly lower, amounting to 1.11% (<jats:italic>P<\/jats:italic> = 0.020). Such results may confirm that the growth rate of vestibular schwannomas varies and may explain the difficulties in estimating the growth of neuromas on the basis of clinical aspects only.<\/jats:p>","DOI":"10.1067\/mhn.2000.111356","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"779-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Correlation between Ki\u201067 index and some clinical aspects of acoustic neuromas (vestibular schwannomas)"],"prefix":"10.1002","volume":"123","author":[{"given":"Kazimierz","family":"Niemczyk","sequence":"first","affiliation":[{"name":"Department of Otology and Oto\u2010Neurology University Regional Hospital Center of Lille Lille France"},{"name":"Department of Otolaryngology Medical Academy of Warsaw Institute of Physiology and Pathology of Hearing Warsaw 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