{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:34:04Z","timestamp":1761006844743,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>The objective of this study was to determine a possible association between pharyngolaryngeal signs of gastroesophageal reflux (GER) and hypertrophy of the lymphoid follicles at the base of the tongue (HBT). For this purpose, 306 patients submitted to videolaryngoscopy were studied retrospectively and classified according to the presence and size of follicles on the base of the tongue. HBT was considered to be present when the follicles prevented the view of the vallecula. The patients were grouped according to the presence of videolaryngoscopic signs of GER and further subdivided according to the presence of esophageal, pharyngolaryngeal, and esophagopharyngolaryngeal symptoms, with an attempt made to relate these symptoms to the presence of HBT. HBT was detected in 62.4% (63\/101) of the patients with signs of GER and in 29.3% (60\/205) of patients with no signs of GER. When HBT incidence was studied according to the symptoms reported by the patient, the condition was found to be present in 57.2% (8\/14) of patients with exclusively esophageal symptoms, in 63.6% (21\/33) with esophagopharyngolaryngeal symptoms, and in 75% (15\/20) with exclusively pharyngolaryngeal symptoms. We conclude therefore that HBT is associated with GER.<\/jats:p>","DOI":"10.1067\/mhn.2000.98362","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T14:34:23Z","timestamp":1369060463000},"page":"607-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of gastroesophageal reflux on hypertrophy of the base of the tongue"],"prefix":"10.1002","volume":"122","author":[{"given":"Rui Celso Martins","family":"Mamede","sequence":"first","affiliation":[{"name":"Department of Surgery Orthopedics and Traumatology University Hospital Faculty of Medicine of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Verissimo","family":"De Mello\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Surgery Orthopedics and Traumatology University Hospital Faculty of Medicine of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lineu celso","family":"Vig\u00e1rio","sequence":"additional","affiliation":[{"name":"Department of Surgery Orthopedics and Traumatology University Hospital Faculty of Medicine of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Oliveira","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Faculty of Medicine of Ribeir\u00e3o Preto Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"381","volume-title":"Imunofisiologia do anel linfatico de Waldeyer","author":"Cruz OML","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(96)90071-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1996.11.111"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(05)70339-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100905"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100068687"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.42.1.42"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90196-R"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90079-Q"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989670003-7"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.98362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2000.98362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2000.98362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:18:32Z","timestamp":1760955512000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2000.98362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1067\/mhn.2000.98362"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2000.98362","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}