{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:56:46Z","timestamp":1788580606794,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5722,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the effectiveness of organ\u2010preserving CO<jats:sub>2<\/jats:sub> laser microsurgery for the treatment of piriform sinus carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective review of 129 previously untreated patients undergoing CO<jats:sub>2<\/jats:sub> laser microsurgery for the treatment of squamous cell carcinomas of the piriform sinus from 1981 to December 1996 was undertaken. The intention was complete tumor removal by preserving functionally important structures of the larynx. Distribution of tumors (Union Internationale Contre le Cancer\/American Joint Committee on Cancer, 1992) was 24 cases with pT1, 74 with pT2, 17 with pT3, and 14 with pT4 disease. Node status was positive in 68% of patients. Seventy\u2010five percent of patients had stage III or IV disease. Forty\u2010two percent of the patients were treated solely with surgery, and 58% had surgery and postoperative radiotherapy. The median follow\u2010up interval was 44\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eighty\u2010seven percent of patients were controlled locally. Neck recurrences occurred in 14.0% of patients, metachronous distant metastases with locoregional control in 6.2%, and second primary tumors in 18.6%. Twenty percent of patients died of TNM\u2010related deaths. The 5\u2010year overall Kaplan\u2010Meier survival rate was 71% for stages I and II and 47% for stages III and IV disease; the 5\u2010year recurrence\u2010free survival rates were 95% and 69%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>A comparatively low local recurrence rate, a high recurrence\u2010free survival rate, and the avoidance of laryngectomy favor function\u2010preserving surgery of piriform sinus carcinomas. 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