{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:27:55Z","timestamp":1762954075902,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5632,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To develop an alternative method for prolonged middle ear ventilation using topical mitomycin C.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Twenty guinea pigs with normal ears had bilateral myringotomies performed using the argon laser. After myringotomy, either mitomycin C (0.4\u00a0mg\/mL) or saline pledgets were applied topically. Monitoring consisted of otomicroscopy and distortion\u2010product otoacoustic emissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Before myringotomy, all tympanic membranes were intact, and distortion\u2010product otoacoustic emissions were measurable. After myringotomy, none (0%) of the saline\u2010treated myringotomies were patent at day 7 as compared with 100% of the mitomycin C\u2010treated myringotomies. At day 42, 10 (52.6%) of 19\u00a0mitomycin\u2010treated myringotomies remained patent and 4 (28.6%) of 14 were patent at 131\u00a0days. Five (13.1%) ears developed purulent otorrhea; 3 were mitomycin C\u2010treated and 2 were treated with saline solution. Distortion\u2010product otoacoustic emissions testing did not document any evidence of ototoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Topical mitomycin C appears to be safe and effective at prolonging the duration of myringotomy patency in the guinea pig.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Mitomycin C may be useful as an adjunct for preventing myringotomy closure.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.114255","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"368-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Safety and Efficacy of Topical Mitomycin C in Myringotomy Patency"],"prefix":"10.1002","volume":"124","author":[{"given":"David","family":"Jassir","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Miami School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Buchman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Miami School of Medicine Miami Florida"},{"name":"Department of Cell Biology Anatomy University of Miami School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Gomez\u2010Marin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Miami School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"642","article-title":"Complications and sequelae of nonsurgical and surgical management of otitis media","volume":"71","author":"Bluestone CD","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_6_3_1","first-page":"540","volume-title":"Pediatric otolaryngology","author":"Bluestone CD","year":"1996"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199204000-00003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S601"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989670002-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(90)32456-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00061-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907000-00022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199806000-00017"},{"key":"e_1_2_6_11_1","first-page":"29","article-title":"Otoacoustic emissions in otologic practice","volume":"15","author":"Balkany T","year":"1994","journal-title":"Am J Otol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.423340"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70316-5"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.114255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.114255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.114255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:26:45Z","timestamp":1760959605000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.114255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1067\/mhn.2001.114255"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.114255","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2001,4]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}