{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:47:48Z","timestamp":1789062468855,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5632,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>The etiopathogenesis of acute unilateral peripheral vestibulopathy (APV) still remains a matter of debate; ischemic changes in the circulation of the labyrinth may play a role. We consequently looked for possible hemostasis alterations in a group of patients with APV of an unknown nature.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We evaluated blood parameters known to be involved in circulation disorders, including total and HDL cholesterol, tryglycerides, apolipoprotein A and B, lipoprotein(a), homocysteine, folate, prothrombin time, activated partial thromboplastin time, fibrinogen, D\u2010dimer, antithrombin III, protein C, protein S, activated protein C resistance, and anticardiolipin IgG and IgM antibodies. A series of 23 patients affected with APV were consecutively referred to our department, in the acute phase, before treatment, and in the follow\u2010up phase after 4 to 6 weeks of pharmacologic washout. The aforementioned blood parameters were also measured in a series of 15 patients with Meni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The patients with APV in the acute phase compared with the patients with Meni\u00e8re's disease in the acute phase exhibited increased plasma levels of fibrinogen (mean, 338.3 \u00b1 135.9 SD vs 271.3 \u00b1 69.8 SD mg\/dL, <jats:italic>P<\/jats:italic> = 0.05), increased plasma levels of D\u2010dimer (mean, 320 \u00b1 207.8 SD vs 226.7 \u00b1 138.7 SD NG\/mL), enhanced plasma levels of lipoprotein(a) (41.4 \u00b1 38.6 SD vs 16 \u00b1 18.2 SD mg\/dL, F = 5.67, <jats:italic>P<\/jats:italic> = 0.02), high leukocyte count (9.1 \u00b1 2.7 SD vs 6.5 \u00b1 1.3 SD x 10<jats:sup>3<\/jats:sup>\/\u03bcL; F = 8.42, <jats:italic>P<\/jats:italic> &lt; 0.006), and low serum folate concentration (5.3 \u00b1 1.8 SD vs 7.1 \u00b1 2.7\u00a0NG\/mg; F = 4.34, <jats:italic>P<\/jats:italic> = 0.04). During follow\u2010up the prothrombin time was prolonged (F = 4.34, <jats:italic>P<\/jats:italic> = 0.04) and leukocyte count decreased (F = 7.39, <jats:italic>P<\/jats:italic> &lt; 0.019) in the APV patients, whereas fibrinogen, D\u2010dimer, lipoprotein(a), and folate were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results provide evidence suggesting an involvement of the hemostatic system in APV.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.114795","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hemostatic Alterations in Patients with Acute, Unilateral Vestibular Paresis"],"prefix":"10.1002","volume":"124","author":[{"given":"Bruno","family":"Fattori","sequence":"first","affiliation":[{"name":"Department of Neuroscience Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nacci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Casani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renza","family":"Cristofani","sequence":"additional","affiliation":[{"name":"Department of Public Health and Biostatistics Institute of Clinical Physiology of National Centre for Research Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sagripanti","sequence":"additional","affiliation":[{"name":"ENT Unit, and the Department of Internal Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"318","volume-title":"Disorders of the vestibular system","author":"B\u00f6hmer A.","year":"1996"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00203.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199909)46:3<416::AID-ANA20>3.0.CO;2-W"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05430-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520390047014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.94"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.9.703"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.7.864"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(98)00047-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","unstructured":"MeadeTW ChakrabartiR HainesAP et al.Haemostatic function and cardiovascular death: Early results of a prospective study.Lancet1980;1050\u20135.","DOI":"10.1016\/S0140-6736(80)91498-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03400090067035"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1222936.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90108-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.2.475"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988809800208"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509125281"},{"key":"e_1_2_5_19_1","first-page":"318","article-title":"Vestibular disorders in primary thrombocytosis","volume":"28","author":"De Ciccio M","year":"1999","journal-title":"J Otolaryngol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.146.8.1497"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570312-8"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.114795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.114795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.114795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:26:54Z","timestamp":1760959614000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.114795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1067\/mhn.2001.114795"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.114795","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}