{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:36:42Z","timestamp":1761007002516,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>The increasing number of surviving pediatric organ transplant recipients has resulted in a new clinical controversy surrounding the significance of adenotonsillar hypertrophy. The objective of this study is to evaluate adenotonsillar specimens, understand characteristic histopathology, and to examine the frequency and significance of this finding in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010one cases of pediatric transplant recipients with adenoidal and\/or tonsillar hypertrophy were reviewed retrospectively in a tertiary\u2010care setting. Particular attention was given to the histopathology of their surgical specimens, including any evidence of posttransplantation lymphoproliferative disorders (PTLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Using morphologic, immunohistochemical, and molecular genetic analyses, 15 (71%) of 21 patients were noted to have Epstein\u2010Barr virus (EBV)\u2010related lymphoid hyperplasia, including 1 case (4.7%) of PTLD. Six (29%) of 21 had evidence of reactive follicular hyperplasia not related to EBV. B\u2010cell and T\u2010cell markers were nearly uniformly positive when tested for, except in the single patient with PTLD, who exhibited polymorphic, polyclonal B\u2010cell morphology. Kappa and lambda light\u2010chain clonality markers were positive in 11 (92%) of 12 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>EBV\u2010related lymphoid hyperplasia is frequently associated with adenotonsillar hypertrophy in pediatric organ transplant patients (71% of our cases); 92% of those cases tested exhibit polyclonal B\u2010cell populations. PTLD, an important cause of morbidity and mortality in this population, represented approximately 5% of our cases. The remainder of cases represent follicular hyperplasia unrelated to EBV or lymphoproliferative abnormalities. Characteristic histopathologic findings are presented.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.116447","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adenotonsillar Histopathology After Organ Transplantation"],"prefix":"10.1002","volume":"125","author":[{"given":"Robert A.","family":"Williamson","sequence":"first","affiliation":[{"name":"Division of Head and Neck Surgery Department of Surgery UCLA School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Department of Surgery UCLA School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina L.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery Department of Surgery UCLA School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(20)30708-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.2.159"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"38","article-title":"Risk factors and pathogenesis of posttransplant lymphoproliferative disorders","volume":"27","author":"Ho M.","year":"1995","journal-title":"Transplant Proc"},{"key":"e_1_2_6_5_1","first-page":"100","article-title":"Epstein\u2010Barr viral infection and posttransplantation lymphoproliferative disorders","volume":"1","author":"Rustgi VK","year":"1995","journal-title":"Liver Transplant Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199608150-00012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199810270-00014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199812270-00006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00287-5"},{"key":"e_1_2_6_10_1","first-page":"8","article-title":"Posttransplant lymphoproliferative disorders: Summary of Society for Hematopathology Workshop","volume":"14","author":"Harris NL","year":"1997","journal-title":"Semin Diag Path"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199711270-00011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1399-0012.1992.tb00630.x","article-title":"Experience with post\u2010transplant lymphoproliferative disorders in solid organ transplant recipients","volume":"6","author":"Nalesnik MA","year":"1992","journal-title":"Clin Transplant"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199401000-00017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.12.1444"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404283301703"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.589"},{"key":"e_1_2_6_17_1","first-page":"263","article-title":"Immunological responses to Epstein\u2010Barr virus infection and the pathogenesis of EBV\u2010induce diseases","volume":"948","author":"Thorley\u2010Lawson DA","year":"1988","journal-title":"Biochem Biophys Acta"},{"key":"e_1_2_6_18_1","first-page":"1921","volume-title":"Virology","author":"Miller G.","year":"1990"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.2.273"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.116447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.116447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.116447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:59:13Z","timestamp":1760957953000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.116447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1067\/mhn.2001.116447"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.116447","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}