{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:49:53Z","timestamp":1768909793101,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,9]]},"abstract":"OBJECTIVE<\/jats:title>To study the efficacy of nebulized topical saline\u2010tobramycin solution in patients with chronic rhinosinusitis refractory to medical and surgical therapy.<\/jats:p><\/jats:sec>STUDY DESIGN AND SETTING<\/jats:title>Twenty patients in whom endoscopic sinus surgery failed to relieve symptoms entered a randomized, double\u2010blind trial of tobramycin\u2010saline solution or saline\u2010only solution administered thrice daily to the nasal passages by means of a large\u2010particle nebulizer apparatus for 4 weeks, followed by a 4\u2010week observation period. Outcome measures of symptoms, quality of life, and endoscopic aspect of sinus mucosa were assessed.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>Both treatments were well tolerated and produced equivalent improvement in symptoms, quality of life, and mucosal aspect. Treatment with the tobramycin\u2010saline solution gave more rapid improvement of pain, but led to the development of nasal congestion.<\/jats:p><\/jats:sec>CONCLUSION<\/jats:title>Therapy with a 4\u2010week course of large\u2010particle nebulized aerosol therapy improves symptomatology and objective parameters of rhinosinusitis in patients refractory to surgical and medical therapies. Addition of tobramycin appears of minimal benefit. The mechanism of this effect is unexplained.<\/jats:p><\/jats:sec>SIGNIFICANCE<\/jats:title>Large\u2010particle nebulized aerosol therapy may offer a safe and effective management alternative for patients with refractory rhinosinusitis.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.117410","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"265-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Treatment of Chronic Rhinosinusitis Refractory to Other Treatments with Topical Antibiotic Therapy Delivered by Means of a Large\u2010Particle Nebulizer: Results of a Controlled Trial"],"prefix":"10.1002","volume":"125","author":[{"given":"Martin Y.","family":"Desrosiers","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology and Allergy The Montreal General Hospital McGill University Health Center Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagros","family":"Salas\u2010Prato","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and Allergy The Montreal General Hospital McGill University Health Center Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770006-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100117463"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199001000-00016"},{"issue":"57","key":"e_1_2_6_5_1","first-page":"1","article-title":"Prognostic factors, outcomes, and staging in ethmoid sinus surgery","volume":"102","author":"Kennedy DW","year":"1992","journal-title":"Laryngoscope"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200007000-00023"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Treatment of mucopurulent rhinosinusitis with a new method of nasal irrigation","author":"Bonsetti GL","year":"1993","journal-title":"L'Arcispedale S Anna di Ferrara"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282403"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70048-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90068-X"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.117410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.117410","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.117410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:59:09Z","timestamp":1760957949000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.117410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1067\/mhn.2001.117410"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.117410","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}