{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:41:02Z","timestamp":1760960462721,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>This study evaluates the effectiveness and safety of fiberoptic carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser welding for graft closure of tympanic membrane perforations in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Tympanic membrane perforation was surgically induced in 11 eardrums of 7 given pigs. A lumbar facial graft was placed over the wound, and albumin drops served as a biologic solder. CO<jats:sub>2<\/jats:sub> laser energy, transmitted through silver halide infrared transmitting fibers, was used for \u201espot\u2010welding\u201c along the circumference of the graft. The welded sites were evaluated by using a surgical microscope as well as by evaluating the sites histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Healing started 3 to 4\u00a0days after surgery and was completed within 3 weeks with the formation of a neotympanum. Some inflammation with granulation tissue was noted in 5 eardrums.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS AND SIGNIFICANCE<\/jats:title><jats:p>These preliminary results indicate that CO<jats:sub>2<\/jats:sub> laser tympanoplasty with a fiberoptic delivery system may be a promising new technique for the clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.117867","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"157-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Carbon Dioxide Laser and Silver Halide Infrared Transmitting Fibers for Tympanoplasty: An Experimental Animal Model"],"prefix":"10.1002","volume":"125","author":[{"given":"Zeev","family":"Zilkerc","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2014Head and Neck Surgery and Laser Research Rabin Medical Center Petah Tiqva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben I.","family":"Nageris","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2014Head and Neck Surgery and Laser Research Rabin Medical Center Petah Tiqva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Feinmesser","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2014Head and Neck Surgery and Laser Research Rabin Medical Center Petah Tiqva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Fridman","sequence":"additional","affiliation":[{"name":"Department of Pathology Sheba Medical Center Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Ravid","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Exact Sciences and Sackler School of Medicine Tel Aviv University Tel Aviv 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