{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:41:06Z","timestamp":1761007266349,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine fungal allergen reactivity prevalence by intradermal dilutional testing in patients with and without chronic rhinitis or rhinosinusitis symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Prospective comparison of fungal allergen reactivity prevalence in symptomatic and asymptomatic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>University medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Group I (chronic rhinitis and\/or rhinosinusitis symptoms) and Group II (asymptomatic) patients underwent intradermal dilutional testing with usual and fungal allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fungal reactivity occurred in 65% (13\/20) of Group I, and 13% (4\/30) of Group II (<jats:italic>P<\/jats:italic> &lt; 0.0002 by <jats:italic>\u03c7<\/jats:italic> <jats:sup>2<\/jats:sup> testing). Group I was more reactive to non\u2010fungal allergens (85% vs. 33%, <jats:italic>p<\/jats:italic> &lt; 0.0004), and to all allergens considered together (95% vs. 40%, <jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Patients with chronic rhinitis and rhinosinusitis symptoms were more reactive to fungal and nonfungal allergens. Fungal allergens were as likely as nonfungal to elicit reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>These findings suggest a role for fungal hypersensitivity in chronic rhinitis and chronic rhinosinusitis.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.119969","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"491-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Hypersensitivity to Specific Fungal Allergens as Determined by Intradermal Dilutional Testing"],"prefix":"10.1002","volume":"125","author":[{"given":"Robert H.","family":"Stroud","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen H.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Center for Diseases of the Nose and Sinuses Amarillo Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199108000-00003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100508"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199409000-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70153-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(00)80014-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.9.877"},{"key":"e_1_2_6_8_1","first-page":"367","volume-title":"Allergy in ENT practice","author":"King HC","year":"1998"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110961"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(00)80018-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00907.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00509.x-i1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb00279.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199811000-00007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70027-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70153-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200005000-00010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100503"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.119969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.119969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.119969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:15:47Z","timestamp":1760962547000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.119969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1067\/mhn.2001.119969"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.119969","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}