{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:40:14Z","timestamp":1761007214599,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5388,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Intraoperative parathyroid gland identification and preservation is often a challenge even in the hands of experienced surgeons as they could be indistinguishable from fat or thyroid tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The goal of this study was to demonstrate the use of the Cytoscan Model E\u2010II, which uses orthogonal polarization spectral (OPS) imaging technology, as an intravital microscope in identifying parathyroid glands intraoperatively and differentiating the parathyroid glands from fat and thyroid tissue in a rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The necks of 4\u00a0New England white rabbits were explored with the animals under a general anesthesia. The Cytoscan was used to obtain images of the vasculature of tissue suspected to be parathyroid, fat, and thyroid tissue. These were confirmed by histologic evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All tissues were correctly identified by the Cytoscan and confirmed by histologic analysis. There was an obvious difference in the images obtained of fatty tissue as compared with parathyroid tissues. There was also an appreciable difference between parathyroid and thyroid tissue based on the difference in vascularity.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>OPS imaging technology can be used in identifying parathyroid glands based on the difference in vascularity from fat and the pattern and density of vessels when compared with thyroid tissue in a rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>The Cytoscan may play a future role in real time intraoperative identification of human parathyroid glands. Future investigation is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2001.120696","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"635-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Cytoscan Model E\u2010II in Intraoperative Parathyroid Gland Identification in a Rabbit Model"],"prefix":"10.1002","volume":"125","author":[{"given":"Ifeolumipo O.","family":"Sofola","sequence":"first","affiliation":[{"name":"Naval Hospital Rota Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Pazos","sequence":"additional","affiliation":[{"name":"National Capital Consortium Otolaryngology\u2010Head and Neck Surgery National Naval Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Buttolph","sequence":"additional","affiliation":[{"name":"Department of Pathology National Naval Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Casler","sequence":"additional","affiliation":[{"name":"National Capital Consortium Otolaryngology\u2010Head and Neck Surgery Walter Reed Army Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Leonard","sequence":"additional","affiliation":[{"name":"National Capital Consortium Otolaryngology\u2010Head and Neck Surgery National Naval Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/13529"},{"key":"e_1_2_6_3_1","first-page":"F761","article-title":"Surgical thyroparathyroidectomy of the rabbit","volume":"252","author":"Tan SQ","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000054079"},{"key":"e_1_2_6_5_1","first-page":"25","article-title":"Parathyroid localization with technetium\u201099m\u2010sestamibi: A prospective evaluation","volume":"183","author":"Mchenry C","year":"1996","journal-title":"J Am Coll Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200001000-00005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80040-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728759"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.5.550"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00100-7"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.120696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2001.120696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2001.120696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:04:22Z","timestamp":1760961862000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2001.120696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1067\/mhn.2001.120696"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2001.120696","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2001,12]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}