{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:14Z","timestamp":1761007514199,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5326,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The goal of the present study was to identify levels of leukotrienes released by leukocytes and nasal polyps from aspirin\u2010sensitive patients (ASPs) and non\u2010aspirin\u2010sensitive patients (NASPs) after exposure to various concentrations of aspirin. Eosinophil expressions of apoptosis regulators were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Leukotriene release from nasal polyps and leukocytes of ASPs and NASPs was measured after exposure to differing concentrations of aspirin. Eosinophils were analyzed for Fas and Fas ligand receptors using flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>NASPs showed increased leukotriene release from nasal polyps on increased aspirin exposure. Polyps from ASPs did not show any change. ASPs showed greater leukotriene release from blood on increasing aspirin exposure compared with NASPs. Flow cytometric analysis showed eosinophils in the peripheral blood of ASPs have decreased Fas expression compared with those of NASPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study showed differences in leukotriene release and eosinophil apoptosis between ASPs and NASPs.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2002.121913","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aspirin\u2010Sensitive versus Non\u2010Aspirin\u2010Sensitive Nasal Polyp Patients: Analysis of Leukotrienes\/fas and Fas\u2010Ligand Expression"],"prefix":"10.1002","volume":"126","author":[{"given":"Nancy E.","family":"Ziroli","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stritch School of Medicine Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanjo","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chosun University Hospital Kwang Ju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stritch School of Medicine Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Stankiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stritch School of Medicine Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Samter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stritch School of Medicine Loyola University Medical Center Maywood Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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