{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:22Z","timestamp":1761006922426,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5206,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The study purpose was to investigate the prevalence of elevated heat shock protein 70 (HSP\u201070) in patients with Meniere's disease who have milk allergy compared with those who are not allergic to milk.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Fifty\u2010five patients with Meniere's disease and allergy in whom milk allergy had been confirmed by intradermal progressive dilutional food testing or skin testing to milk antigen were included. Blood serum was tested for HSP\u201070 elevation with a Western blot assay using bovine renal extract. The 29 women and 26\u00a0men ranged in age from 29 to 76 years (mean age 52.8 years). Forty percent of the patients had bilateral Meniere's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall prevalence of HSP\u201070 elevation was 29.1%. This was higher in bilateral patients (50%) than unilateral patients (15%) (<jats:italic>P<\/jats:italic> \u2264 0.007). The effect was based primarily on elevated HSP\u201070\u00a0in bilateral (62.5%) and unilateral (7.7%) patients in those with no milk allergy (<jats:italic>P<\/jats:italic> \u2264 0.006). The prevalence of HSP\u201070 elevation was actually lower in those with milk allergy (19.2%) than in those with no milk allergy (37.9%). This difference was statistically significant only in the subset of patients who were &lt;50 years old (0% vs 33.3%, respectively; <jats:italic>P<\/jats:italic> \u2264 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We found no relationship between the presence of antibodies to HSP\u201070 and allergy to milk. The significance of elevated HSP\u201070\u00a0in patients with Meniere's disease has yet to be defined.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2002.125297","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"677-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of Heat Shock Protein in Patients with Meniere's Disease and Allergy"],"prefix":"10.1002","volume":"126","author":[{"given":"M. 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