{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:46Z","timestamp":1761006946532,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5206,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Our goal was to analyze p63 and 14\u20103\u20103\u03c3 expression in normal and hyperdifferentiated head and neck mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Compare the in vivo expression of p63 and 14\u20103\u20103\u03c3 by immunohistochemistry in normal mucosa and oral lichen planus, a benign mucosal lesion marked by hyperdifferentiation and apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS AND CONCLUSION<\/jats:title><jats:p>p63 is underexpressed and 14\u20103\u20103\u03c3 is overexpressed in lichen planus on immunohistochemical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>The findings support the hypothesis that p63 plays an antidifferentiation role, whereas 14\u20103\u20103\u03c3 plays a prodifferentiation role in the upper aerodigestive tract epithelium. Lichen planus is a valuable model for the study of p63, 14\u20103\u20103\u03c3, and mucosal differentiation. p63 and 14\u20103\u20103\u03c3 may be molecular markers for oral lichen planus.<\/jats:p><\/jats:sec>","DOI":"10.1067\/mhn.2002.125302","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:49:09Z","timestamp":1044395349000},"page":"598-601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Expression of p63 and 14\u20103\u20103\u03c3 in Normal and Hyperdifferentiated Mucosa of the Upper Aerodigestive Tract"],"prefix":"10.1002","volume":"126","author":[{"given":"Joseph C.","family":"Sniezek","sequence":"first","affiliation":[{"name":"Department of Otolaryngology The Vanderbilt\u2010Ingram Comprehensive Cancer Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith E.","family":"Matheny","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Vanderbilt\u2010Ingram Comprehensive Cancer Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian B.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Vanderbilt\u2010Ingram Comprehensive Cancer Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Netterville","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Vanderbilt\u2010Ingram Comprehensive Cancer Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Pietenpol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry The Vanderbilt\u2010Ingram Comprehensive Cancer Center Nashville Tennessee"},{"name":"Center in Molecular Toxicology Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80275-0"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/19539"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/19531"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00780.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35043127"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/44188"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/344503a0"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.5.1117"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70116-2"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb01994.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061032098"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0194-5998(02)00024-4?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2002.125302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0194-5998(02)00024-4?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1067\/mhn.2002.125302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1067\/mhn.2002.125302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:49:20Z","timestamp":1760957360000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1067\/mhn.2002.125302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1067\/mhn.2002.125302"],"URL":"https:\/\/doi.org\/10.1067\/mhn.2002.125302","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"2016-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}