{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:06:06Z","timestamp":1759334766655,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1067\/mjd.2000.101880","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:17:12Z","timestamp":1027556232000},"page":"946-954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P2","title":["Nonerythrodermic, leukemic variant of cutaneous T-cell lymphoma with indolent clinical course: Th2-type tumor cells lacking T-cell receptor\/CD3 expression and coinfiltrating tumoricidal CD8+ T cells"],"prefix":"10.1067","volume":"43","author":[{"given":"Yoshiki","family":"Tokura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mjd.2000.101880_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0190-9622(80)80385-9","article-title":"Cutaneous T-cell lymphoma: mycosis fungoides, S\u00e9zary syndrome, and other variants","volume":"2","author":"Edelson","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1523-1747.ep12494184","article-title":"Stimulation of cutaneous T-cell lymphoma cells with superantigenic staphylococcal toxins","volume":"98","author":"Tokura","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib3","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/0190-9622(90)70080-2","article-title":"Leu-8\/CD7 antigen expression by CD3+ T cells: comparative analysis of skin and blood in mycosis fungoides\/S\u00e9zary syndrome relative to normal blood values","volume":"22","author":"Wood","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2567.1996.d01-744.x","article-title":"CD7-negative T cells represent a separate differentiation pathway in a subset of post-thymic helper T cells","volume":"89","author":"Reinhold","year":"1996","journal-title":"Immunology"},{"key":"10.1067\/mjd.2000.101880_bib5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/1523-1747.ep12611877","article-title":"Aberrant cytokine production by S\u00e9zary syndrome patients: cytokine secretion pattern resembles murine Th2 cells","volume":"99","author":"Vowels","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib6","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V76.7.1361.1361","article-title":"A new monoclonal antibody (CH-F42) recognizes a CD7- subset of normal T lymphocytes and circulating malignant cells in adult T-cell lymphoma-leukemia and S\u00e9zary syndrome","volume":"76","author":"Labastide","year":"1990","journal-title":"Blood"},{"key":"10.1067\/mjd.2000.101880_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0190-9622(07)80011-9","article-title":"CD7-positive S\u00e9zary syndrome with a Th1 cytokine profile","volume":"34","author":"Yagi","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib8","first-page":"1285","article-title":"Lymphoma, pseudolymphoma and related conditions","author":"Heald","year":"1993"},{"key":"10.1067\/mjd.2000.101880_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/1523-1747.ep12606046","article-title":"Defective TCR surface expression associated with impaired TCR beta-chain assembly in a patient with cutaneous T-cell lymphoma","volume":"104","author":"Fischer","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib10","first-page":"1053","article-title":"A unique phenotype of skin-associated lymphocytes in humans: preferential expression of the HECA-452 epitope by benign and maliganant T cells at cutaneous sites","volume":"136","author":"Picker","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1067\/mjd.2000.101880_bib11","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1073\/pnas.82.22.7701","article-title":"Low frequency of somatic mutation in b-chain variable region genes of human T-cell receptors","volume":"82","author":"Ikuta","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mjd.2000.101880_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2249.1998.00599.x","article-title":"Tumour-specific cytotoxic T lymphocyte activity in Th2-type S\u00e9zary syndrome: its enhancement by interferon-gamma (IFN-\u03b3) and IL-12 and fluctuations in association with disease activity","volume":"112","author":"Seo","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1067\/mjd.2000.101880_bib13","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1001\/archderm.1986.01660240064017","article-title":"Lymphomatoid papulosis: histologic and immunohistochemical studies in a patient with a scaly pigmented eruption","volume":"122","author":"Tokura","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0022-1759(89)90142-7","article-title":"Cell-mediated cytotoxicity: a highly sensitive and informative flow cytometric assay","volume":"117","author":"Slezak","year":"1989","journal-title":"J Immunol Methods"},{"key":"10.1067\/mjd.2000.101880_bib15","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1073\/pnas.95.8.4538","article-title":"Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras","volume":"95","author":"Porcu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mjd.2000.101880_bib16","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood.V86.3.1163.1163","article-title":"True T-cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases","volume":"86","author":"Hoyer","year":"1995","journal-title":"Blood"},{"key":"10.1067\/mjd.2000.101880_bib17","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze","year":"1997","journal-title":"Blood"},{"key":"10.1067\/mjd.2000.101880_bib18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archderm.1995.01690210039007","article-title":"Primary cutaneous pleomorphic small T-cell lymphoma: a review of 11 cases","volume":"131","author":"Friedmann","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1365-2249.1998.00649.x","article-title":"Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with S\u00e9zary syndrome","volume":"113","author":"Sano","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1067\/mjd.2000.101880_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/1523-1747.ep12364814","article-title":"Skin-selective lymphocyte homing mechanisms in the pathogenesis of leukemic cutaneous T-cell lymphoma","volume":"101","author":"Heald","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib21","first-page":"1203","article-title":"Familial defect in the surface expression of the T cell receptor-CD3 complex","volume":"319","author":"Alarcon","year":"1988","journal-title":"Nature"},{"key":"10.1067\/mjd.2000.101880_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2340\/0001555560111","article-title":"Lymphocyte-epidermis interactions in malignant epidermotropic lymphomas: I, ultrastmctural aspects","volume":"60","author":"Schmitt","year":"1980","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"10.1067\/mjd.2000.101880_bib23","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0190-9622(82)70077-5","article-title":"Demonstration of OKT 6-positive cells in mycosis fungoides","volume":"6","author":"McMillan","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00412686","article-title":"Role of Langerhans cells in epidermotropism of T cells","volume":"280","author":"Shiohara","year":"1988","journal-title":"Arch Dermatol Res"},{"key":"10.1067\/mjd.2000.101880_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2133.1994.tb02905.x","article-title":"Cutaneous T-cell lymphoma with massive co-infiltration of polyclonal B cells","volume":"130","author":"Yagi","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/1523-1747.ep12363378","article-title":"The immune response to class I-associated tumor-specific cutaneous T-cell lymphoma antigens","volume":"107","author":"Berger","year":"1996","journal-title":"J Invest Dennatol"},{"key":"10.1067\/mjd.2000.101880_bib27","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/1523-1747.ep12330845","article-title":"Th2 cytokine mRNA expression in primary cutaneous CD30-positive lymphoproliferative disorders: successful treatment with recombinant interferon-\u03b3","volume":"107","author":"Yagi","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2000.101880_bib28","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.4049\/jimmunol.142.10.3452","article-title":"IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes","volume":"142","author":"Kawakami","year":"1989","journal-title":"J Immunol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962200846861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962200846861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T21:23:18Z","timestamp":1759267398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962200846861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["S0190962200846861"],"URL":"https:\/\/doi.org\/10.1067\/mjd.2000.101880","relation":{},"ISSN":["0190-9622"],"issn-type":[{"type":"print","value":"0190-9622"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonerythrodermic, leukemic variant of cutaneous T-cell lymphoma with indolent clinical course: Th2-type tumor cells lacking T-cell receptor\/CD3 expression and coinfiltrating tumoricidal CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mjd.2000.101880","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}