{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:28:36Z","timestamp":1772753316956,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1067\/mjd.2002.126580","type":"journal-article","created":{"date-parts":[[2003,5,27]],"date-time":"2003-05-27T23:08:28Z","timestamp":1054076908000},"page":"S225-S228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"S","title":["Treatment of squamous cell carcinoma in situ of the penis with 5% imiquimod cream: A case report"],"prefix":"10.1067","volume":"47","author":[{"given":"Ida","family":"Orengo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie K.","family":"Guill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mjd.2002.126580_bib1","first-page":"416","article-title":"Squamous cell carcinoma of the penis","volume":"82","author":"Hunter-Mellado","year":"1990","journal-title":"Bol Assoc Med P R"},{"key":"10.1067\/mjd.2002.126580_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jso.2930520114","article-title":"Carcinoma of the penis: the Indian experience","volume":"52","author":"Kamat","year":"1993","journal-title":"J Surg Oncol"},{"issue":"Suppl 1","key":"10.1067\/mjd.2002.126580_bib3","first-page":"17","article-title":"Squamous cell carcinoma of the penis","volume":"31","author":"Schoeneich","year":"1999","journal-title":"Andrologia"},{"key":"10.1067\/mjd.2002.126580_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1386-6532(00)00131-1","article-title":"The Uganda study on HPV variants and genital cancers","volume":"19","author":"Buonaguro","year":"2000","journal-title":"J Clin Virol"},{"key":"10.1067\/mjd.2002.126580_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-642-81095-4_11","article-title":"Epidemiology of cancer of the penis","volume":"60","author":"Persky","year":"1977","journal-title":"Recent Results Cancer Res"},{"key":"10.1067\/mjd.2002.126580_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0094-0143(21)00387-6","article-title":"Penile cancer. Clinical presentation, diagnosis and staging","volume":"19","author":"Burgers","year":"1992","journal-title":"Urol Clin North Am"},{"key":"10.1067\/mjd.2002.126580_bib7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0190-9622(96)90611-8","article-title":"Squamous cell carcinoma of the penis","volume":"35","author":"Micali","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0094-0143(21)01783-3","article-title":"Common penile lesions","volume":"15","author":"Coldiron","year":"1988","journal-title":"Urol Clin North Am"},{"key":"10.1067\/mjd.2002.126580_bib9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0022-5347(17)35099-1","article-title":"Carcinoma in-situ of the penis","volume":"151","author":"Gerber","year":"1994","journal-title":"J Urol"},{"key":"10.1067\/mjd.2002.126580_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0094-0143(21)00390-6","article-title":"Penile amputations for the management of primary carcinoma of the penis","volume":"19","author":"Das","year":"1992","journal-title":"Urol Clin North Am"},{"key":"10.1067\/mjd.2002.126580_bib11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0190-9622(98)70243-9","article-title":"Treatment of genital warts with an immune response modifier (imiquimod)","volume":"38","author":"Beutner","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archderm.134.1.25","article-title":"Self-administered topical 5% imiquimod cream for external anogenital warts. HPV Study Group. Human papillomavirus","volume":"134","author":"Edwards","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0022-5347(01)66967-2","article-title":"The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis","volume":"154","author":"Cupp","year":"1995","journal-title":"J Urol"},{"key":"10.1067\/mjd.2002.126580_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/00365590050509913","article-title":"Etiology of squamous cell carcinoma of the penis","volume":"40","author":"Dillner","year":"2000","journal-title":"Scand J Urol Nephrol Suppl"},{"key":"10.1067\/mjd.2002.126580_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0192-0561(98)00068-X","article-title":"Imiquimod applied topically: a novel immune response modifier and new class of drug","volume":"21","author":"Miller","year":"1999","journal-title":"Int J Immunopharmacol"},{"key":"10.1067\/mjd.2002.126580_bib16","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jama.1975.03250090024012","article-title":"Erythroplasia of Queyrat. Treatment with topically applied fluorouracil","volume":"232","author":"Goette","year":"1975","journal-title":"JAMA"},{"key":"10.1067\/mjd.2002.126580_bib17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0090-4295(76)90087-X","article-title":"Bowen's disease of the shaft of the penis. Successful treatment with 5-fluorouracil","volume":"7","author":"Tolia","year":"1976","journal-title":"Urology"},{"key":"10.1067\/mjd.2002.126580_bib18","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(82)92034-7","article-title":"Etretinate in bowenoid papulosis [letter]","volume":"1","author":"de Mari","year":"1982","journal-title":"Lancet"},{"key":"10.1067\/mjd.2002.126580_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-2133.1982.tb04562.x","article-title":"Treatment of erythroplasia of Queyrat with liquid nitrogen cryosurgery","volume":"106","author":"Sonnex","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2133.1988.tb03205.x","article-title":"Cryotherapy for skin cancer: results over a 5-year period using liquid nitrogen spray cryosurgery","volume":"119","author":"Holt","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0090-4295(85)90278-X","article-title":"Carbon dioxide laser treatment of external genital lesions","volume":"25","author":"Rosemberg","year":"1985","journal-title":"Urology"},{"key":"10.1067\/mjd.2002.126580_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0090-4295(88)90566-3","article-title":"Carcinoma of the penis treated with neodymium:YAG laser","volume":"31","author":"Malloy","year":"1988","journal-title":"Urology"},{"key":"10.1067\/mjd.2002.126580_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/lsm.1900120303","article-title":"Laser treatment of premalignant and malignant squamous lesions of the penis","volume":"12","author":"Malek","year":"1992","journal-title":"Lasers Surg Med"},{"key":"10.1067\/mjd.2002.126580_bib24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0090-4295(98)00308-2","article-title":"Laser therapy of squamous cell dysplasia and carcinoma of the penis","volume":"52","author":"Tietjen","year":"1998","journal-title":"Urology"},{"key":"10.1067\/mjd.2002.126580_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0094-0143(21)00391-8","article-title":"Conservative extirpative treatment of cancer of the penis","volume":"19","author":"Bissada","year":"1992","journal-title":"Urol Clin North Am"},{"key":"10.1067\/mjd.2002.126580_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1524-4725.1991.tb01714.x","article-title":"Extensive Bowen's disease of the penile shaft treated with fresh tissue Mohs micrographic surgery in two separate operations","volume":"17","author":"Mortiz","year":"1991","journal-title":"J Dermatol Surg Oncol"},{"key":"10.1067\/mjd.2002.126580_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0094-0143(21)00392-X","article-title":"Mohs micrographic surgery for penile tumors","volume":"19","author":"Mohs","year":"1992","journal-title":"Urol Clin North Am"},{"key":"10.1067\/mjd.2002.126580_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/jir.1994.14.81","article-title":"Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood cells in vitro","volume":"14","author":"Weeks","year":"1994","journal-title":"J Interferon Res"},{"key":"10.1067\/mjd.2002.126580_bib29","first-page":"71","article-title":"Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression","volume":"13","author":"Kono","year":"1994","journal-title":"Lymphokine Cytokine Res"},{"key":"10.1067\/mjd.2002.126580_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0166-3542(99)00033-9","article-title":"Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5%","volume":"43","author":"Arany","year":"1999","journal-title":"Antiviral Res"},{"key":"10.1067\/mjd.2002.126580_bib31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1523-1747.2000.00833.x","article-title":"Imiquimod, a topical immune response modifier, induces migration of Langerhans cells","volume":"114","author":"Suzuki","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib32","first-page":"307","article-title":"The biology and significance of human papillomavirus infections in the genital tract","volume":"61","author":"Reid","year":"1988","journal-title":"Yale J Biol Med"},{"key":"10.1067\/mjd.2002.126580_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0166-0934(91)90130-R","article-title":"Detection of human papillomavirus types 6, 11, 16 and 18 in mucosal and cutaneous lesions by the multiplex polymerase chain reaction","volume":"35","author":"Soler","year":"1991","journal-title":"J Virol Methods"},{"key":"10.1067\/mjd.2002.126580_bib34","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1056\/NEJM198710083171502","article-title":"High prevalence of papillomavirus-associated penile intraepithelial neoplasia in sexual partners of women with cervical intraepithelial neoplasia","volume":"317","author":"Barrasso","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1067\/mjd.2002.126580_bib35","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1002\/1097-0142(19940915)74:6<1762::AID-CNCR2820740619>3.0.CO;2-1","article-title":"Penile intraepithelial neoplasia. Specific clinical features correlate with histologic and virologic findings","volume":"74","author":"Aynaud","year":"1994","journal-title":"Cancer"},{"key":"10.1067\/mjd.2002.126580_bib36","first-page":"619","article-title":"Self-administered topical imiquimod treatment of vulvar intraepithelial neoplasia. A report of four cases","volume":"45","author":"Davis","year":"2000","journal-title":"J Reprod Med"},{"key":"10.1067\/mjd.2002.126580_bib37","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1067\/mjd.2002.120584","article-title":"Treatment of Bowen's disease of the penis with imiquimod","volume":"46","author":"Thai","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mjd.2002.126580_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1067\/mjd.2002.120444","article-title":"Squamous cell carcinoma in situ of the penis successfully treated with imiquimod 5% cream","volume":"46","author":"Schroeder","year":"2002","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962202001196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962202001196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T21:25:34Z","timestamp":1759267534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962202001196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0190962202001196"],"URL":"https:\/\/doi.org\/10.1067\/mjd.2002.126580","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of squamous cell carcinoma in situ of the penis with 5% imiquimod cream: A case report","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mjd.2002.126580","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}