{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:25:15Z","timestamp":1770744315292,"version":"3.49.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Laboratory and Clinical Medicine"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1067\/mlc.2003.28","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T01:57:29Z","timestamp":1051754249000},"page":"279-282","source":"Crossref","is-referenced-by-count":37,"title":["UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia"],"prefix":"10.1067","volume":"141","author":[{"given":"Matthew M.","family":"Heeney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thad A.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherri A.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell E.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mlc.2003.28_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2362.1980.tb00023.x","article-title":"Glucuronidation of bilirubin and the occurrence of pigment gallstones in patients with chronic haemolytic diseases","volume":"10","author":"Fevery","year":"1980","journal-title":"Eur J Clin Invest"},{"key":"10.1067\/mlc.2003.28_bib2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0895-4356(92)90073-V","article-title":"Laboratory profile of sickle cell disease: a cross-sectional analysis","volume":"45","author":"West","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"10.1067\/mlc.2003.28_bib3","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/00043426-200110000-00011","article-title":"The influence of bilirubin UDP-glucuronosyltransferase 1A (UGT1A) promoter polymorphisms on serum bilirubin levels and cholelithiasis in pediatric patients with sickle cell anemia","volume":"23","author":"Passon","year":"2001","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1067\/mlc.2003.28_bib4","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood.V94.7.2259.419k42_2259_2262","article-title":"Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis","volume":"94","author":"Del Giudice","year":"1999","journal-title":"Blood"},{"key":"10.1067\/mlc.2003.28_bib5","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1073\/pnas.94.22.12128","article-title":"Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia","volume":"94","author":"Kaplan","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mlc.2003.28_bib6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1046\/j.1365-2141.1997.4113228.x","article-title":"The expression of uridine diphosphate glucuronosyltransferase gene is a major determinant of bilirubin level in heterozygous \u03b2-thalassaemia and in glucose-6-phosphate dehydrogenase deficiency","volume":"99","author":"Sampietro","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1067\/mlc.2003.28_bib7","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1046\/j.1365-2141.2001.03200.x","article-title":"Cholelithiasis and Gilbert's syndrome in homozygous beta-thalassaemia","volume":"115","author":"Galanello","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1067\/mlc.2003.28_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1542\/peds.64.5.601","article-title":"The prevalence of cholelithiasis in sickle cell disease as diagnosed by ultrasound and cholecystography","volume":"64","author":"Lachman","year":"1979","journal-title":"Pediatrics"},{"key":"10.1067\/mlc.2003.28_bib9","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0022-3476(80)80626-3","article-title":"Incidence of cholelithiasis in sickle cell anemia using the ultrasonic gray-scale technique","volume":"96","author":"Sarnaik","year":"1980","journal-title":"J Pediatr"},{"key":"10.1067\/mlc.2003.28_bib10","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/0016-5085(86)90276-3","article-title":"Hepatobiliary system in sickle cell disease","volume":"90","author":"Schubert","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1067\/mlc.2003.28_bib11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1001\/archinte.1980.00330170064026","article-title":"Cholelithiasis in sickle cell anemia: surgical or medical management","volume":"140","author":"Stephens","year":"1980","journal-title":"Arch Intern Med"},{"key":"10.1067\/mlc.2003.28_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000658-198807000-00003","article-title":"Elective cholecystectomy in young patients with sickle hemoglobinopathies: successful outcome using a preoperative transfusion program","volume":"208","author":"Ware","year":"1988","journal-title":"Ann Surg"},{"key":"10.1067\/mlc.2003.28_bib13","first-page":"1533","article-title":"Cholecystectomy in sickle cell anemia patients: perioperative outcome of 364 cases from the National Preoperative Transfusion Study","volume":"89","author":"Haberkern","year":"1997","journal-title":"Blood"},{"key":"10.1067\/mlc.2003.28_bib14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The genetic basis of the reduced expression of bilirubin UDP-glucuronosyl-transferase 1 in Gilbert's syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1067\/mlc.2003.28_bib15","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","article-title":"Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert syndrome","volume":"347","author":"Monaghan","year":"1996","journal-title":"Lancet"},{"key":"10.1067\/mlc.2003.28_bib16","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","article-title":"Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A) promoter: a balanced polymorphism for regulation of bilirubin metabolism?","volume":"95","author":"Beutler","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1067\/mlc.2003.28_bib17","first-page":"1550","article-title":"Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I\/II trial","volume":"94","author":"Kinney","year":"1999","journal-title":"Blood"}],"container-title":["Journal of Laboratory and Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214302930350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214302930350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:20:33Z","timestamp":1682475633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022214302930350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0022214302930350"],"URL":"https:\/\/doi.org\/10.1067\/mlc.2003.28","relation":{},"ISSN":["0022-2143"],"issn-type":[{"value":"0022-2143","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}