{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:53:52Z","timestamp":1792709632593,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1067\/mob.2000.95834","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:15:43Z","timestamp":1027570543000},"page":"1173-1183","source":"Crossref","is-referenced-by-count":250,"title":["An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: A randomized, double-blind, placebo-controlled trial with tocolytic rescue"],"prefix":"10.1067","volume":"182","author":[{"given":"Roberto","family":"Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha M.","family":"Sibai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Sanchez-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo J.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Veille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bannie","family":"Tabor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Varner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.Murphy","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanne","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Shangold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Creasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2000.95834_bib1","series-title":"Report of the Consensus Development Conference on the effect of corticosteroids for fetal maturation on perinatal outcomes","year":"1994"},{"key":"10.1067\/mob.2000.95834_bib2","first-page":"465","article-title":"Neonatal consequences of preterm birth","author":"Brown","year":"1993"},{"key":"10.1067\/mob.2000.95834_bib3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/00003081-198809000-00012","article-title":"Follow-up of prematurely born infants","volume":"31","author":"Escobedo","year":"1988","journal-title":"Clin Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib4","first-page":"277","article-title":"Etiology and outcome of low birth weight and preterm infants","volume":"60","author":"Arias","year":"1982","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1471-0528.1988.tb06860.x","article-title":"Betamimetics in preterm labour: an overview of the randomized controlled trials","volume":"95","author":"King","year":"1988","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1067\/mob.2000.95834_bib6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1056\/NEJM199207303270503","article-title":"Treatment of preterm labor with the beta-adrenergic agonist ritodrine","volume":"327","author":"The Canadian Preterm Labor Investigators Group","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2000.95834_bib7","first-page":"712","article-title":"Ritodrine hydrochloride: a beta-mimetic agent for use in preterm labor. II. Evidence of efficacy","volume":"56","author":"Merkatz","year":"1980","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0002-9378(93)90144-8","article-title":"Sudden death associated with terbutaline sulfate administration","volume":"169","author":"Hudgens","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0002-9378(81)90524-X","article-title":"Cardiovascular complications associated with terbutaline treatment for preterm labor","volume":"139","author":"Katz","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0002-9378(12)90894-7","article-title":"Effect of prolonged oral terbutaline therapy on glucose tolerance in pregnancy","volume":"168","author":"Foley","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0029-7844(94)00374-M","article-title":"Efficacy of oral beta-agonist maintenance therapy in preterm labor: a meta-analysis","volume":"85","author":"Macones","year":"1995","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/0002-9378(91)90569-D","article-title":"Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor","volume":"164","author":"Besinger","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib13","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1210\/jcem-71-5-1243","article-title":"Regulation of intracellular free calcium in human myometrial cells by prostaglandin F2 alpha: comparison with oxytocin","volume":"71","author":"Molnar","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2000.95834_bib14","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1056\/NEJM199311253292202","article-title":"Neonatal complications after the administration of indomethacin for preterm labor","volume":"329","author":"Norton","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2000.95834_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0167-0115(93)90180-G","article-title":"Uterine oxytocin gene expression: a novel framework for oxytocin action","volume":"45","author":"Zingg","year":"1993","journal-title":"Regul Pept"},{"key":"10.1067\/mob.2000.95834_bib16","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0002-9378(12)90793-0","article-title":"Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women","volume":"165","author":"Fuchs","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib17","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","article-title":"Oxytocin receptors in the human uterus during pregnancy and parturition","volume":"150","author":"Fuchs","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib18","first-page":"289","article-title":"Oxytocin receptors and the onset of parturition","author":"Soloff","year":"1985"},{"key":"10.1067\/mob.2000.95834_bib19","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1471-0528.1987.tb02287.x","article-title":"Inhibition of uterine contractions of premature labour with an oxytocin analogue: results from a pilot study","volume":"94","author":"Akerlund","year":"1987","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1067\/mob.2000.95834_bib20","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1210\/endo.137.8.8754755","article-title":"The oxytocin antagonist atosiban prevents androstenedione-induced myometrial contractions in the chronically instrumented, pregnant rhesus monkey","volume":"137","author":"Giussani","year":"1996","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2000.95834_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0002-9378(94)70214-4","article-title":"The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human","volume":"170","author":"Goodwin","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib22","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0002-9378(95)90365-8","article-title":"The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions","volume":"173","author":"Goodwin","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0029-7844(96)00200-1","article-title":"Dose ranging study of the oxytocin antagonist atosiban in the treatment of preterm labor","volume":"88","author":"Goodwin","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib24","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/0002-9378(94)90414-6","article-title":"Effect of oxytocin antagonists on the activation of human myometrium in vitro: atosiban prevents oxytocin-induced desensitization","volume":"171","author":"Phaneuf","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/biomet\/68.1.316","article-title":"The asymptotic properties of nonparametric tests for comparing survival distributions","volume":"68","author":"Schoenfeld","year":"1981","journal-title":"Biometrika"},{"key":"10.1067\/mob.2000.95834_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/009286159102500311","article-title":"The application of the principle of intention-to-treat to the analysis of clinicial trials","volume":"25","author":"Gillings","year":"1991","journal-title":"Drug Inform J"},{"key":"10.1067\/mob.2000.95834_bib27","first-page":"1","article-title":"Statistical methods for survival data analysis","author":"Lee","year":"1992"},{"key":"10.1067\/mob.2000.95834_bib28","unstructured":"WHOART version 1992, third quarter. WHO, The Uppsala Monitoring Center, WHO Collaborating Centre for International Drug Monitoring, Stora Torget 3, S-753 20 Uppsala, Sweden."},{"key":"10.1067\/mob.2000.95834_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJM199807303390506","article-title":"Prevention of premature birth","volume":"339","author":"Goldenberg","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2000.95834_bib30","first-page":"194","article-title":"Preterm labour","author":"Keirse","year":"1989"},{"key":"10.1067\/mob.2000.95834_bib31","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1749-6632.1994.tb21771.x","article-title":"The pretem labor syndrome","volume":"734","author":"Romero","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"10.1067\/mob.2000.95834_bib32","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0002-9378(89)90409-2","article-title":"Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes","volume":"161","author":"Romero","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","volume":"179","author":"Gomez","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib34","first-page":"134","article-title":"Perinatal fluid and electrolyte regulation: role of arginine vasopressin","volume":"12","author":"Gore","year":"1989","journal-title":"Semin Perinatol"},{"key":"10.1067\/mob.2000.95834_bib35","first-page":"198","article-title":"Advisory Committee for Reproductive Health Drugs","year":"1998"},{"key":"10.1067\/mob.2000.95834_bib36","series-title":"Pooled analysis of the CAP-001 studies","author":"Advisory Committee for Reproductive Health Drugs","year":"1998"},{"key":"10.1067\/mob.2000.95834_bib37","first-page":"24","article-title":"Advisory Committee for Reproductive Health Drugs","year":"1998"},{"key":"10.1067\/mob.2000.95834_bib38","first-page":"243","article-title":"Basic research and clinical experiences with \u03b2-adrenergic tocolytics in the United States","author":"Creasy","year":"1993"},{"key":"10.1067\/mob.2000.95834_bib39","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1067\/mob.2000.104950","article-title":"Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study","volume":"182","author":"Moutquin","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib40","first-page":"60","article-title":"Advisory Committee for Reproductive Health Drugs","year":"1998"},{"key":"10.1067\/mob.2000.95834_bib41","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1056\/NEJM199708143370705","article-title":"The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants","volume":"337","author":"Shankaran","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2000.95834_bib42","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(97)24047-X","article-title":"Is tocolytic magnesium sulphate associated with increased total paediatric mortality?","volume":"350","author":"Mittendorf","year":"1997","journal-title":"Lancet"},{"key":"10.1067\/mob.2000.95834_bib43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0029-7844(98)00163-X","article-title":"If tocolytic magnesium sulfate is associated with excess total pediatric mortality, what is its impact?","volume":"92","author":"Mittendorf","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2000.95834_bib44","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0140-6736(95)91034-4","article-title":"Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial","volume":"345","author":"The Eclampsia Trial Collaborative Group","year":"1995","journal-title":"Lancet"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937800701827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937800701827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T14:53:04Z","timestamp":1557413584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937800701827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0002937800701827"],"URL":"https:\/\/doi.org\/10.1067\/mob.2000.95834","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}