{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:25:16Z","timestamp":1770963916671,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1067\/mob.2001.109596","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:19:27Z","timestamp":1027570767000},"page":"289-296","source":"Crossref","is-referenced-by-count":48,"title":["Relationship of the metabolic syndrome and obesity to polycystic ovary syndrome: A controlled, population-based study"],"prefix":"10.1067","volume":"184","author":[{"given":"Seija","family":"Korhonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritta","family":"Hippel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauno","family":"Vanhala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Saarikoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2001.109596_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1210\/jcem-50-1-113","article-title":"Correlation of hyperandrogenism with hyper-insulinism in polycystic ovarian disease","volume":"50","author":"Burghen","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0002-9378(83)90091-1","article-title":"Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features","volume":"147","author":"Barbieri","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2001.109596_bib3","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"key":"10.1067\/mob.2001.109596_bib4","first-page":"774","article-title":"Insulin resistance and the polycystic ovarian syndrome: mechanisms and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1067\/mob.2001.109596_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1210\/jcem-72-1-83","article-title":"A direct effect of hyperinsulinemia on serum sex hormone\u2013binding globulin levels in obese women with the polycystic ovary syndrome","volume":"72","author":"Nestler","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib6","first-page":"57","article-title":"The association of obesity with infertility and related menstrual abnormalities in women","volume":"3","author":"Hartz","year":"1979","journal-title":"Int J Obesity"},{"key":"10.1067\/mob.2001.109596_bib7","first-page":"3281","article-title":"Obesity, androgens, estrogens and cancer risk","volume":"42","author":"Kirschner","year":"1982","journal-title":"Cancer Res"},{"key":"10.1067\/mob.2001.109596_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0026-0495(81)90224-9","article-title":"Endocrine function in human obesity","volume":"30","author":"Glass","year":"1981","journal-title":"Metabolism"},{"key":"10.1067\/mob.2001.109596_bib9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1210\/jcem-59-5-949","article-title":"Elevated production and metabolic clearance rates of androgens in morbidly obese women","volume":"59","author":"Samojlik","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/jcem-57-2-304","article-title":"Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women","volume":"57","author":"Evans","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM199602083340607","article-title":"Hypertension and associated metabolic abnormalities: the role of insulin resistance and the sympathoadrenal system","volume":"334","author":"Reaven","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2001.109596_bib12","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Role of insulin resistance in human disease [Banting Lecture 1988]","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"10.1067\/mob.2001.109596_bib13","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1001\/archinte.1989.00390070054005","article-title":"The deadly quartet: upper-body obesity, glucose intolerance, hypertriglyceridemia and hypertension","volume":"149","author":"Kaplan","year":"1989","journal-title":"Arch Intern Med"},{"key":"10.1067\/mob.2001.109596_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/j.1550-8528.1993.tb00614.x","article-title":"Visceral obesity: \u201ca civilization syndrome.\u201d","volume":"1","author":"Bj\u00f6rntorp","year":"1993","journal-title":"Obes Res"},{"key":"10.1067\/mob.2001.109596_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/07853899209166997","article-title":"Abdominal obesity and the metabolic syndrome","volume":"24","author":"Bj\u00f6rntorp","year":"1992","journal-title":"Ann Med"},{"key":"10.1067\/mob.2001.109596_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00043798-199708000-00010","article-title":"Metabolic syndrome in a middle\u2013aged Finnish population","volume":"4","author":"Vanhala","year":"1997","journal-title":"Cardiovasc Risk Factors"},{"key":"10.1067\/mob.2001.109596_bib17","series-title":"Report of WHO Study Group on Diabetes Mellitus","author":"World Health Organization","year":"1985"},{"key":"10.1067\/mob.2001.109596_bib18","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/jcem-21-11-1440","article-title":"Clinical assessment of body hair growth in women","volume":"21","author":"Ferriman","year":"1961","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2265.1974.tb03298.x","article-title":"Sex hormone binding globulin","volume":"3","author":"Anderson","year":"1974","journal-title":"Clin Endocrinol"},{"key":"10.1067\/mob.2001.109596_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1055\/s-2007-1016294","article-title":"Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications","volume":"15","author":"Nestler","year":"1997","journal-title":"Semin Reprod Endocrinol"},{"key":"10.1067\/mob.2001.109596_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2796.1994.tb01031.x","article-title":"Hyperinsulinemia, obesity and syndrome X","volume":"235","author":"Zavaroni","year":"1994","journal-title":"J Intern Med"},{"key":"10.1067\/mob.2001.109596_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabet Med"},{"key":"10.1067\/mob.2001.109596_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0950-351X(96)80113-3","article-title":"Polycystic ovary syndrome: clinical aspects","volume":"10","author":"Conway","year":"1996","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"10.1067\/mob.2001.109596_bib24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ijc.2910500413","article-title":"Body mass at different ages and subsequent endometrial cancer risk","volume":"50","author":"Levi","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1067\/mob.2001.109596_bib25","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(88)91612-1","article-title":"Polycystic ovaries: a common finding in normal women","volume":"1","author":"Polson","year":"1988","journal-title":"Lancet"},{"key":"10.1067\/mob.2001.109596_bib26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/j.1550-8528.1994.tb00077.x","article-title":"The quantitative relationship between \u201cthe metabolic syndrome\u201d and abdominal obesity in women","volume":"2","author":"Lapidus","year":"1994","journal-title":"Obes Res"},{"key":"10.1067\/mob.2001.109596_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/bmj.317.7154.329","article-title":"Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology","volume":"317","author":"Hopkinson","year":"1998","journal-title":"BMJ"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937801598713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937801598713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:21:56Z","timestamp":1557408116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937801598713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0002937801598713"],"URL":"https:\/\/doi.org\/10.1067\/mob.2001.109596","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}