{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:05:16Z","timestamp":1790395516872,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1067\/mob.2001.111245","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:20:53Z","timestamp":1027570853000},"page":"910-916","source":"Crossref","is-referenced-by-count":11,"title":["Effects of 15 months of 17\u03b2-estradiol and dydrogesterone on systolic cardiac function according to quantitative and Doppler echocardiography in healthy postmenopausal women"],"prefix":"10.1067","volume":"184","author":[{"given":"Hilda","family":"Kessel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kenemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velja","family":"Mijatovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.Marchien","family":"van Baal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees A.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius J.","family":"van der Mooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2001.111245_bib1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM198704303161801","article-title":"Menopause and the risk of coronary heart disease in women","volume":"316","author":"Colditz","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2001.111245_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM199608153350701","article-title":"Postmenopausal estrogen and progestogen use and the risk of cardiovascular disease","volume":"335","author":"Grodstein","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2001.111245_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0301-2115(96)02634-6","article-title":"Hormone replacement therapy and cardioprotection: basic concepts and clinical considerations","volume":"71","author":"Pines","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1067\/mob.2001.111245_bib4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0029-7844(97)00704-7","article-title":"A randomized controlled study of the effects of 17\u03b2-estradiol-dydrogesterone on plasma homocysteine in postmenopausal women","volume":"91","author":"Mijatovic","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2001.111245_bib5","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1001\/archinte.1990.00390230101014","article-title":"Estrogen replacement and coronary artery disease: effect on survival in postmenopausal women","volume":"150","author":"Sullivan","year":"1990","journal-title":"Arch Intern Med"},{"key":"10.1067\/mob.2001.111245_bib6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen\/progestin Replacement Study (HERS) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"10.1067\/mob.2001.111245_bib7","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/0002-9149(92)90877-2","article-title":"Menopause-induced changes in Doppler-derived parameters of aortic flow in healthy women","volume":"69","author":"Pines","year":"1992","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000175033","article-title":"Menopause-related changes in left ventricular function in healthy women","volume":"80","author":"Pines","year":"1992","journal-title":"Cardiology"},{"key":"10.1067\/mob.2001.111245_bib9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0002-9149(93)90171-8","article-title":"Menopause-induced changes in left ventricular wall thickness","volume":"72","author":"Pines","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib10","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/01.HYP.32.4.764","article-title":"Early cardiac changes after menopause","volume":"32","author":"Schilacci","year":"1998","journal-title":"Hypertension"},{"key":"10.1067\/mob.2001.111245_bib11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0002-9149(99)80310-5","article-title":"Effect of menopause on left ventricular filling in 50 year old women","volume":"76","author":"Kangro","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0002-9378(91)90520-2","article-title":"The effects of hormone replacement therapy in normal postmenopausal women: measurements of Doppler-derived parameters of aortic flow","volume":"164","author":"Pines","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2001.111245_bib13","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1378\/chest.102.5.1496","article-title":"Long-term effects of hormone replacement therapy on Doppler-derived parameters of aortic flow in postmenopausal women","volume":"102","author":"Pines","year":"1992","journal-title":"Chest"},{"key":"10.1067\/mob.2001.111245_bib14","first-page":"53","article-title":"Left ventricular function during a short-term transdermal estradiol therapy in post-menopausal women: a double-blind placebo-controlled echocardiographic study","volume":"3","author":"Pines","year":"1996","journal-title":"Eur Menopause J"},{"key":"10.1067\/mob.2001.111245_bib15","first-page":"22","article-title":"The longterm effects of transdermal estradiol on left ventricular function and dimensions","volume":"2","author":"Pines","year":"1995","journal-title":"Eur Menopause J"},{"key":"10.1067\/mob.2001.111245_bib16","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0002-9149(96)00646-7","article-title":"Exercise echocardiography in postmenopausal hormone users with mild systemic hypertension","volume":"78","author":"Pines","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00042192-199805020-00004","article-title":"The effects of sublingual estradiol on left ventricular function at rest and exercise in postmenopausal women: an echocardiographic assessment","volume":"5","author":"Pines","year":"1998","journal-title":"Menopause"},{"key":"10.1067\/mob.2001.111245_bib18","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0002-9149(97)00520-1","article-title":"Effect of acute administration of estradiol 17 beta on aortic blood flow in menopausal women","volume":"80","author":"Leonardo","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0002-9149(93)90525-H","article-title":"Left ventricular function by Doppler echocardiography in relation to hormonal replacement therapy in healthy postmenopausal women","volume":"71","author":"Voutilainen","year":"1993","journal-title":"Am J Cardiol"},{"key":"10.1067\/mob.2001.111245_bib20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0029-7844(96)00521-2","article-title":"Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial","volume":"89","author":"Snabes","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2001.111245_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0015-0282(98)00398-7","article-title":"Effect of short-term hormone replacement therapy on left ventricular mass and contractile function","volume":"71","author":"Sites","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1067\/mob.2001.111245_bib22","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/0002-9378(93)90287-S","article-title":"Blood flow variations in internal carotid and middle cerebral arteries induced by postmenopausal hormone replacement therapy","volume":"169","author":"Penotti","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2001.111245_bib23","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9378(99)70377-7","article-title":"Sequentially combined hormone replacement therapy reduces impedance to flow within the uterine and central retinal arteries in healthy postmenopausal women","volume":"181","author":"van Baal","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl","key":"10.1067\/mob.2001.111245_bib24","first-page":"S52","article-title":"Doppler echocardiography as a non-invasive hemodynamic technique in pregnancy","volume":"42","author":"Kamp","year":"1991","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1067\/mob.2001.111245_bib25","first-page":"77","article-title":"Is too much estrogen bad for the heart? [editorial]","volume":"5","author":"Sullivan","year":"1998","journal-title":"Menopause"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937801122325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937801122325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:53:34Z","timestamp":1557402814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937801122325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0002937801122325"],"URL":"https:\/\/doi.org\/10.1067\/mob.2001.111245","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}