{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:12:29Z","timestamp":1790223149118,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1067\/mob.2002.123938","type":"journal-article","created":{"date-parts":[[2002,11,5]],"date-time":"2002-11-05T13:49:19Z","timestamp":1036504159000},"page":"521-527","source":"Crossref","is-referenced-by-count":99,"title":["Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study"],"prefix":"10.1067","volume":"187","author":[{"given":"Steven R.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayan","family":"Nanavati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2002.123938_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0960-0760(00)00102-3","article-title":"A structural biologist's view of the oestrogen receptor","volume":"74","author":"Pike","year":"2000","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1067\/mob.2002.123938_bib2","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1056\/NEJM198812293192601","article-title":"Effects of tamoxifen and of cytoxic therapy on mortality in early breast cancer: an overview of 61 randomized trials among 28896 women","volume":"319","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2002.123938_bib3","first-page":"237","article-title":"Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens","volume":"69","author":"Killackey","year":"1985","journal-title":"Cancer Treat Rep"},{"key":"10.1067\/mob.2002.123938_bib4","first-page":"447","article-title":"Unusual ultrasonographic appearance of the uterus in patients receiving tamoxifen","volume":"170","author":"Goldstein","year":"1994","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0028-2243(90)90167-Y","article-title":"Hysteroscopic follow-up during tamoxifen treatment","volume":"35","author":"Neven","year":"1990","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1067\/mob.2002.123938_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1469-0705.1998.11010048.x","article-title":"The use of transvaginal ultrasound and saline infusion sonohysterography for the evaluation of asymptomatic postmenopausal beast cancer patients on tamoxifen","volume":"11","author":"Schwartz","year":"1998","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib7","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study","volume":"90","author":"Fisher","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1067\/mob.2002.123938_bib8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.7863\/jum.1999.18.7.503","article-title":"Sonographic assessment of the endometrium in osteopenic postmenopausal women treated with idoxifene","volume":"18","author":"Fleischer","year":"1999","journal-title":"J Ultrasound Med"},{"key":"10.1067\/mob.2002.123938_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0029-7844(99)00502-5","article-title":"A 12-month comparative study of raloxifene, estrogen, and placebo on the postmenopausal endometrium","volume":"95","author":"Goldstein","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib10","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1001\/jama.281.23.2189","article-title":"The effect of raloxifene on risk of breast cancer in postmenopausal women","volume":"281","author":"Cummings","year":"1999","journal-title":"JAMA"},{"key":"10.1067\/mob.2002.123938_bib11","first-page":"3","article-title":"Levormeloxifene, a nonsteroidal estrogen receptor therapeutic, prevents bone loss, reduces serum cholesterol, and has differentiated uterine effects in the ovariectomized rat","author":"Bain","year":"1996","journal-title":"Proceedings of the 8th International Congress on Menopause"},{"key":"10.1067\/mob.2002.123938_bib12","first-page":"3","article-title":"Levormeloxifene, a non-steroidal estrogen receptor therapeutic, reduces serum cholesterol and prevents aortic cholesterol accumulation in cholesterol-fed rabbits","author":"Holm","year":"1996","journal-title":"Proceedings of the 8th International Congress on Menopause"},{"key":"10.1067\/mob.2002.123938_bib13","first-page":"755","article-title":"Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy","volume":"86","author":"Alexandersen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2002.123938_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0029-7844(00)01115-7","article-title":"Postmenopausal hormones and incontinence: the heart and estrogen\/progestin replacement study","volume":"97","author":"Grady","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000293384","article-title":"Changes in urethral cytology following estrogen administration","volume":"29","author":"Bergman","year":"1990","journal-title":"Gynecol Obstet Invest"},{"key":"10.1067\/mob.2002.123938_bib16","first-page":"1014","article-title":"Adenocarcinoma of the endometrium","author":"Burke","year":"1993"},{"key":"10.1067\/mob.2002.123938_bib17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-5122(99)00077-8","article-title":"Effects of postmenopausal hypoestrogenism on skin collagen","volume":"33","author":"Affinito","year":"1999","journal-title":"Maturitas"},{"key":"10.1067\/mob.2002.123938_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-5122(92)90244-X","article-title":"The menopause, urinary incontinence and other symptoms of the genito-urinary tract","volume":"15","author":"Rekers","year":"1992","journal-title":"Maturitas"},{"key":"10.1067\/mob.2002.123938_bib19","first-page":"1243","article-title":"The Canadian Consensus Conference on menopause and osteoporosis","volume":"20","author":"Casper","year":"1998","journal-title":"J Soc Obstet Gynaecol Can"},{"key":"10.1067\/mob.2002.123938_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0029-7844(99)00554-2","article-title":"Uterine effects of three-year raloxifene therapy in postmenopausal women under age 60","volume":"95","author":"Cohen","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib21","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0029-7844(98)00476-1","article-title":"Adverse events reported by postmenopausal women in controlled trials with raloxifene","volume":"93","author":"Davies","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0029-7844(01)01390-4","article-title":"Raloxifene effects on frequency of surgery for pelvic floor relaxation","volume":"98","author":"Goldstein","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib23","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/0024-3205(80)90049-1","article-title":"Uterine bioassay of tamoxifen, trioxifene, and new estrogen antagonist (LY117018) in rats and mice","volume":"26","author":"Black","year":"1980","journal-title":"Life Sci"},{"key":"10.1067\/mob.2002.123938_bib24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1067\/mob.2000.105407","article-title":"The effect of raloxifene on the uterine weight response in immature mice exposed to 17 \u03b2-estradiol, 1,1,1-trichloro-2,2-bis (p -chlorophenyl)ethane, and methoxychlor","volume":"182","author":"Al-Jamal","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2002.123938_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1172\/JCI116985","article-title":"Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats","volume":"93","author":"Black","year":"1994","journal-title":"J Clin Invest"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937802001618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937802001618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T09:50:30Z","timestamp":1554371430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937802001618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0002937802001618"],"URL":"https:\/\/doi.org\/10.1067\/mob.2002.123938","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}