{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:37:29Z","timestamp":1767857849974,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1067\/mob.2003.454","type":"journal-article","created":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T12:38:24Z","timestamp":1056976704000},"page":"1468-1476","source":"Crossref","is-referenced-by-count":23,"title":["Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro"],"prefix":"10.1067","volume":"188","author":[{"given":"Monica","family":"Longo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venu","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri P.","family":"Vedernikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Garfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2003.454_bib1","first-page":"861","article-title":"Relaxin","author":"Sherwood","year":"1994"},{"key":"10.1067\/mob.2003.454_bib2","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/S0021-9258(17)36028-3","article-title":"Changes in relaxin precursor mRNA levels in the rat ovary during pregnancy","volume":"261","author":"Crish","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1067\/mob.2003.454_bib3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1095\/biolreprod59.4.991","article-title":"Identification of specific relaxin-binding cells in the human female","volume":"59","author":"Kohsaka","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1067\/mob.2003.454_bib4","doi-asserted-by":"crossref","first-page":"9396","DOI":"10.1016\/S0021-9258(19)38862-3","article-title":"Preparation of biologically active 32P-labelled human relaxin: displaceable binding to rat uterus, cervix and brain","volume":"265","author":"Osheroff","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1067\/mob.2003.454_bib5","first-page":"585","article-title":"Relaxin in human serum, measured with homologous radioimmunoassay","volume":"69","author":"Bell","year":"1987","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2003.454_bib6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3181\/00379727-190-42857","article-title":"Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin","volume":"190","author":"Massicotte","year":"1989","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1067\/mob.2003.454_bib7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0024-3205(85)90251-6","article-title":"Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats","volume":"37","author":"St-Louis","year":"1985","journal-title":"Life Sci"},{"key":"10.1067\/mob.2003.454_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0306-3623(96)00171-1","article-title":"Relaxin: a pleiotropic hormone","volume":"28","author":"Bani","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1067\/mob.2003.454_bib9","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1111\/j.1476-5381.1995.tb16377.x","article-title":"Relaxin-induced increased in coronary flow through stimulation of nitric oxide production","volume":"116","author":"Bani Sacchi","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mob.2003.454_bib10","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/01.HYP.31.6.1240","article-title":"Relaxin activates the L -arginine-nitric oxide pathway in vascular smooth muscle cells in culture","volume":"31","author":"Bani","year":"1998","journal-title":"Hypertension"},{"key":"10.1067\/mob.2003.454_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0167-0115(99)00007-5","article-title":"On the mechanism of relaxin action: the involvement of adenylyl cyclase signaling system","volume":"80","author":"Kuznetsova","year":"1999","journal-title":"Regul Pept"},{"key":"10.1067\/mob.2003.454_bib12","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/molehr\/7.9.799","article-title":"Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity","volume":"7","author":"Bartsch","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1067\/mob.2003.454_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0889-8529(18)30058-6","article-title":"Relaxin and its role in pregnancy","volume":"24","author":"Goldsmith","year":"1995","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1067\/mob.2003.454_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/jrf.0.0990275","article-title":"Action of relaxin on uterine contractions: a review","volume":"99","author":"Downing","year":"1993","journal-title":"J Reprod Fertil"},{"key":"10.1067\/mob.2003.454_bib15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1172\/JCI5630","article-title":"Relaxin is a potent renal vasodilator in conscious rats","volume":"103","author":"Danielson","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1067\/mob.2003.454_bib16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1677\/joe.0.1400385","article-title":"Characterization of two relaxin genes in the chimpanzee","volume":"140","author":"Evans","year":"1994","journal-title":"J Endocrinol"},{"key":"10.1067\/mob.2003.454_bib17","first-page":"89","article-title":"Solid phase synthesis and biological activity of rat relaxin","volume":"2","author":"Wade","year":"1996","journal-title":"Biomed Pept Proteins Nucleic Acids"},{"key":"10.1067\/mob.2003.454_bib18","first-page":"757","article-title":"Effects of human relaxin on isolated rat and human myometrium and uteroplacental arteries","volume":"78","author":"Petersen","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2003.454_bib19","first-page":"45","article-title":"Control of vascular reactivity in pregnancy: the basis for therapeutic approaches to prevent pregnancy-induced hypertension","volume":"18","author":"Magness","year":"1994","journal-title":"Semin Perinatol"},{"key":"10.1067\/mob.2003.454_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/humrep\/13.1.214","article-title":"Effect of gestational age on in-vitro responses of pregnant rat aorta","volume":"13","author":"Jain","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1067\/mob.2003.454_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1054-3589(08)60669-9","article-title":"Inducible cyclooxygenase and nitric oxide synthase","volume":"33","author":"Wu","year":"1995","journal-title":"Adv Pharmacol"},{"key":"10.1067\/mob.2003.454_bib22","first-page":"409","article-title":"Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips","volume":"8","author":"Holzmann","year":"1982","journal-title":"J Cyclic Nucl Res"},{"key":"10.1067\/mob.2003.454_bib23","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1210\/endo-106-4-1210","article-title":"The interaction of relaxin with rat uterus, I: effect on cyclic nucleotide levels and spontaneous activity","volume":"106","author":"Sanborn","year":"1980","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2003.454_bib24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1530\/jrf.0.0960857","article-title":"Cyclic adenosine 3\u20325\u2032-monophosphate and the relaxant action of relaxin in the rat uterus in vivo","volume":"96","author":"Downing","year":"1992","journal-title":"J Reprod Fertil"},{"key":"10.1067\/mob.2003.454_bib25","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1210\/endo-124-6-2995","article-title":"Antagonism of contractants and relaxants at the level of intracellular calcium and phosphoinositide turnover in the rat uterus","volume":"124","author":"Anwar","year":"1989","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2003.454_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0889-8529(18)30058-6","article-title":"Relaxin and its role in pregnancy","volume":"24","author":"Goldsmith","year":"1995","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1067\/mob.2003.454_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1067\/mob.2001.115865","article-title":"Impairment of growth in fetuses destined to deliver preterm","volume":"185","author":"Bukowski","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.454_bib28","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0024-3205(85)90251-6","article-title":"Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats","volume":"37","author":"St-Louis","year":"1985","journal-title":"Life Sci"},{"key":"10.1067\/mob.2003.454_bib29","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/0002-9378(93)90301-X","article-title":"Gestational changes in L-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle","volume":"169","author":"Izumi","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.454_bib30","first-page":"119A","article-title":"Relaxin-induced vasorelaxation in pregnant rat uterine artery","volume":"8","author":"Longo","year":"2001","journal-title":"J Soc Gynecol Investig"},{"key":"10.1067\/mob.2003.454_bib31","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1095\/biolreprod59.4.991","article-title":"Identification of specific relaxin-binding cells in the human female","volume":"59","author":"Kohsaka","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1067\/mob.2003.454_bib32","first-page":"819","article-title":"Effect of porcine relaxin on spontaneous, oxytocin-driven and prostaglandin-driven pig myometrial activity in vitro","volume":"34","author":"Pupula","year":"1989","journal-title":"J Reprod Med"},{"key":"10.1067\/mob.2003.454_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00003081-199506000-00012","article-title":"Relaxin used to produce the cervical ripening of labor","volume":"38","author":"Weiss","year":"1995","journal-title":"Rev Clin Obstet Gynecol"},{"key":"10.1067\/mob.2003.454_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1210\/endo.140.1.6404","article-title":"Mice without a functional relaxin gene are unable to deliver milk to their pups","volume":"140","author":"Zhao","year":"1999","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2003.454_bib35","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/01.HYP.31.6.1240","article-title":"Relaxin activates the L -arginine-nitric oxide pathway in vascular smooth muscle cells in culture","volume":"31","author":"Bani","year":"1998","journal-title":"Hypertension"},{"key":"10.1067\/mob.2003.454_bib36","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1210\/endo.140.10.7055","article-title":"Relaxin up-regulates the nitric oxide biosynthetic pathway in the mouse uterus: involvement in the inhibition of myometrial contractility","volume":"140","author":"Bani","year":"1999","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2003.454_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.bjp.0702517","article-title":"Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment","volume":"127","author":"Tan","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1067\/mob.2003.454_bib38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1172\/JCI5630","article-title":"Relaxin is a potent renal vasodilator in conscious rats","volume":"103","author":"Danielson","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1067\/mob.2003.454_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0167-0115(99)00007-5","article-title":"On the mechanism of relaxin action: the involvement of adenylyl cyclase signaling system","volume":"80","author":"Kuznetsova","year":"1999","journal-title":"Regul Pept"},{"key":"10.1067\/mob.2003.454_bib40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/molehr\/7.9.799","article-title":"Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity","volume":"7","author":"Bartsch","year":"2001","journal-title":"Mol Hum Reprod"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937803004101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937803004101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T09:20:59Z","timestamp":1623144059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937803004101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0002937803004101"],"URL":"https:\/\/doi.org\/10.1067\/mob.2003.454","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}