{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:48:56Z","timestamp":1790826536266,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1067\/mob.2003.70","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T11:25:29Z","timestamp":1044962729000},"page":"252-263","source":"Crossref","is-referenced-by-count":121,"title":["Dexamethasone or interleukin-10 blocks interleukin-1\u03b2-induced uterine contractions in pregnant rhesus monkeys"],"prefix":"10.1067","volume":"188","author":[{"given":"Drew W.","family":"Sadowsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles J.","family":"Novy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Gravett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mob.2003.70_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0002-9378(98)70271-6","article-title":"A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition","volume":"179","author":"Romero","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/0002-9378(94)90418-9","article-title":"An experimental model for intraamniotic infection and preterm labor in rhesus monkeys","volume":"171","author":"Gravett","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib3","first-page":"173","article-title":"Indomethacin blocks interleukin 1\u03b2-induced myometrial contractions in pregnant rhesus monkeys","volume":"183","author":"Sadowsky","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1086\/314531","article-title":"Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac","volume":"179","author":"Rappaport","year":"1999","journal-title":"J Infect Dis"},{"issue":"Suppl","key":"10.1067\/mob.2003.70_bib5","doi-asserted-by":"crossref","first-page":"I99","DOI":"10.1136\/ard.58.2008.i99","article-title":"Interleukin-10 treatment for rheumatoid arthritis","volume":"58","author":"St. Clair","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"10.1067\/mob.2003.70_bib6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/molehr\/6.6.561","article-title":"NF\u03baB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)","volume":"6","author":"Allport","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1067\/mob.2003.70_bib7","first-page":"435","article-title":"Molecular control of immune-inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways","volume":"20","author":"McKay","year":"1999","journal-title":"Endocr Rev"},{"key":"10.1067\/mob.2003.70_bib8","doi-asserted-by":"crossref","first-page":"31868","DOI":"10.1074\/jbc.274.45.31868","article-title":"Interleukin-10 signaling blocks inhibitor of kappa B kinase activity and nuclear kappa B DNA binding","volume":"274","author":"Schottelius","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1067\/mob.2003.70_bib9","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/0002-9378(83)90841-4","article-title":"Dexamethasone and estradiol treatment in pregnant rhesus macaques: effects on gestational length, maternal plasma hormones, and fetal growth","volume":"145","author":"Novy","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib10","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1093\/humrep\/13.12.3560","article-title":"Cytokine secretion by human fetal membranes, decidua and placenta at term","volume":"13","author":"Denison","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1067\/mob.2003.70_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1071-5576(97)00045-2","article-title":"Expression of interleukin-10 in human gestational tissues","volume":"4","author":"Trautman","year":"1997","journal-title":"J Soc Gynecol Invest"},{"key":"10.1067\/mob.2003.70_bib12","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.4049\/jimmunol.166.4.2674","article-title":"IL-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production","volume":"166","author":"Berg","year":"2001","journal-title":"J Immunol"},{"key":"10.1067\/mob.2003.70_bib13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.179.5.1695","article-title":"Interleukin-10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation","volume":"179","author":"Cassatella","year":"1994","journal-title":"J Exp Med"},{"key":"10.1067\/mob.2003.70_bib14","first-page":"476","article-title":"Interleukin-10 administration and bacterial endotoxin-induced preterm birth in a rat model","volume":"98","author":"Terrone","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib15","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.4049\/jimmunol.154.10.5492","article-title":"A randomized, controlled trial of IL-10 in humans: inhibition of inflammatory cytokine production and immune responses","volume":"154","author":"Chernoff","year":"1995","journal-title":"J Immunol"},{"key":"10.1067\/mob.2003.70_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0009-9236(97)90065-5","article-title":"Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers","volume":"62","author":"Huhn","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1067\/mob.2003.70_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/jcem-73-2-385","article-title":"Endocrine and morphological maturation of the fetal and neonatal adrenal cortex in baboons","volume":"73","author":"Ducsay","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2003.70_bib18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0095-5108(18)30085-X","article-title":"Regulation of parturition update, endocrine and paracrine effector of term and preterm labor","volume":"25","author":"Kniss","year":"1998","journal-title":"Clin Perinatol"},{"key":"10.1067\/mob.2003.70_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1067\/mob.2002.118916","article-title":"Identification of matrix metalloproteinase-9 in amniotic fluid and amniochorion in spontaneous labor and after experimental intrauterine infection or interleukin-1\u03b2 infusion in pregnant rhesus monkeys","volume":"186","author":"Vadillo-Ortega","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0002-9378(97)70272-2","article-title":"Interleukin-10 and transforming growth factor-\u03b2 inhibit amniochorionic tumor necrosis factor-\u03b1 production by contrasting mechanisms of action: therapeutic implications in prematurity","volume":"177","author":"Fortunato","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0165-6147(93)90184-L","article-title":"Anti-inflammatory actions of steroids: molecular mechanisms","volume":"14","author":"Barnes","year":"1993","journal-title":"Trends Pharmacol Sci"},{"key":"10.1067\/mob.2003.70_bib22","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.270.5234.286","article-title":"Immunosuppression by glucocorticoids: inhibition of NF-kB activity through induction of Ik synthesis","volume":"270","author":"Auphan","year":"1995","journal-title":"Science"},{"key":"10.1067\/mob.2003.70_bib23","first-page":"3647","article-title":"Chronic antagonism of nuclear factor-\u03baB activity in cytotrophoblasts by dexamethasone: a potential mechanism for anti-inflammatory action of glucocorticoids in human placenta","volume":"83","author":"Rosen","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2003.70_bib24","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1095\/biolreprod57.6.1438","article-title":"Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide","volume":"57","author":"Keelan","year":"1997","journal-title":"Biol Reprod"},{"key":"10.1067\/mob.2003.70_bib25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1210\/jcem.84.3.5656","article-title":"Increase in plasma interleukin-10 following hydrocortisone injection","volume":"84","author":"Dandona","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2003.70_bib26","first-page":"514","article-title":"Endocrine and paracrine regulation of birth at term and preterm","volume":"21","author":"Challis","year":"2000","journal-title":"Endocrine Rev"},{"key":"10.1067\/mob.2003.70_bib27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0024-3205(96)00590-5","article-title":"Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells","volume":"60","author":"Newton","year":"1997","journal-title":"Life Sci"},{"key":"10.1067\/mob.2003.70_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0952-3278(98)90053-9","article-title":"Interleukin-1\u03b2 and dexamethasone regulate gene expression of prostaglandin H synthase via the NF\u03baB pathway in human amnion derived WISH cells","volume":"59","author":"Wang","year":"1998","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1067\/mob.2003.70_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1054\/plef.1999.0031","article-title":"Cyclic AMP response element mediates dexamethasone suppression of prostaglandin synthase-2 gene expression in human amnion derived WISH cells","volume":"60","author":"Wang","year":"1999","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1067\/mob.2003.70_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/endo.141.2.7313","article-title":"The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone","volume":"141","author":"Greenland","year":"2000","journal-title":"Endocrinology"},{"key":"10.1067\/mob.2003.70_bib31","first-page":"156","article-title":"Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms","volume":"17","author":"Petraglia","year":"1996","journal-title":"Endocr Rev"},{"key":"10.1067\/mob.2003.70_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/1098-2345(200103)53:3<123::AID-AJP3>3.0.CO;2-V","article-title":"Corticotropin-releasing hormone-binding protein in primates","volume":"53","author":"Bowman","year":"2001","journal-title":"Am J Primatol"},{"key":"10.1067\/mob.2003.70_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0029-7844(94)00355-H","article-title":"The effect of corticosteroid administration on uterine activity and preterm labor in high-order multiple gestations","volume":"85","author":"Elliott","year":"1995","journal-title":"Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0301-2115(96)02453-0","article-title":"Uterine activity after betamethasone administration for the enhancement of fetal lung maturation","volume":"67","author":"Yeshaya","year":"1996","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1067\/mob.2003.70_bib35","series-title":"CIBA Foundation Symposium 47. The fetus and birth","first-page":"401","article-title":"Fetal cortisol and the initiation of labor in the human","author":"Gennser","year":"1977"},{"key":"10.1067\/mob.2003.70_bib36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0002-9378(83)90305-8","article-title":"Circadian patterns and dexamethasone induced changes in uterine activity in pregnant rhesus monkeys","volume":"145","author":"Ducsay","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib37","first-page":"57","article-title":"Immunomodulation of Crohn's disease by interleukin-10","volume":"49","author":"Narula","year":"1998","journal-title":"Agents Actions"},{"key":"10.1067\/mob.2003.70_bib38","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0002-9378(96)80053-6","article-title":"Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane: transcriptional regulation","volume":"175","author":"Fortunato","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib39","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0002-9378(98)70085-7","article-title":"The effect of transforming growth factor and IL-10 on IL-8 release by human amniochorion may regulate histologic chorioamnionitis","volume":"179","author":"Fortunato","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib40","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4049\/jimmunol.153.2.811","article-title":"IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells","volume":"153","author":"Wang","year":"1994","journal-title":"J Immunol"},{"key":"10.1067\/mob.2003.70_bib41","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/eji.1830240435","article-title":"Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes","volume":"24","author":"Willems","year":"1994","journal-title":"Eur J Immunol"},{"key":"10.1067\/mob.2003.70_bib42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0016-5085(97)70090-8","article-title":"Interleukin-10 prevents cytokine-induced disruption of T85 monolayer barrier integrity and limits chloride secretion","volume":"113","author":"Madsen","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1067\/mob.2003.70_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0897.1998.tb00060.x","article-title":"Anti-inflammatory effects of interleukin-4, interleukin-10, and transforming growth factor-beta on human placental cells in vitro","volume":"40","author":"Goodwin","year":"1998","journal-title":"Am J Reprod Immunol"},{"key":"10.1067\/mob.2003.70_bib44","first-page":"4645","volume":"84","author":"Pomini","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mob.2003.70_bib45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-0378(97)00020-X","article-title":"Amniotic fluid interleukin-10 (IL-10) concentrations during pregnancy and with labor","volume":"33","author":"Dudley","year":"1997","journal-title":"J Reprod Immunol"},{"key":"10.1067\/mob.2003.70_bib46","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0002-9378(96)70221-1","article-title":"Inflammatory cytokine (interleukins 1, 6, and 8 and tumor necrosis factor-\u03b1) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations","volume":"174","author":"Fortunato","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1530\/jrf.0.1000081","article-title":"Transfer of cytokines through human fetal membranes","volume":"100","author":"Kent","year":"1994","journal-title":"J Reprod Fertil"},{"key":"10.1067\/mob.2003.70_bib48","first-page":"202A","article-title":"The anti-inflammatory cytokine interleukin-10 has proinflammatory effects on human amnion","volume":"6","author":"Simpson","year":"1999","journal-title":"J Soc Gynecol Invest"},{"key":"10.1067\/mob.2003.70_bib49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1365-2567.2000.00942.x","article-title":"The regulation of prostaglandin output from term intact fetal membranes by anti-inflammatory cytokines","volume":"99","author":"Brown","year":"2000","journal-title":"Immunology"},{"key":"10.1067\/mob.2003.70_bib50","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/0002-9378(94)90419-7","article-title":"Induction of interleukin-1 receptor antagonist in rhesus monkeys following intraamniotic infection with Group B streptococci or interleukin-1 infusion","volume":"171","author":"Witkin","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1067\/mob.2003.70_bib51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1071-5576(00)00075-7","article-title":"Antenatal steroid treatment and adverse fetal effects: what is the evidence","volume":"7","author":"Kay","year":"2000","journal-title":"J Soc Gynecol Invest"},{"key":"10.1067\/mob.2003.70_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1479-828X.1993.tb02375.x","article-title":"Corticosteroids for the enhanced fetal lung maturation in patients with HELLP syndrome: impact on neonates","volume":"33","author":"Magann","year":"1993","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1067\/mob.2003.70_bib53","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJM199105303242201","article-title":"The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis","volume":"324","author":"Odio","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1067\/mob.2003.70_bib54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0167-5699(97)80023-0","article-title":"IL-10: a potential therapy for allergic inflammation","volume":"18","author":"Pretolani","year":"1997","journal-title":"Immunol Today"},{"key":"10.1067\/mob.2003.70_bib55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1089\/107999099313532","article-title":"Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience","volume":"19","author":"Huang","year":"1999","journal-title":"J Interferon Cytokine Res"},{"key":"10.1067\/mob.2003.70_bib56","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1086\/514118","article-title":"The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis","volume":"176","author":"Paris","year":"1997","journal-title":"J Infect Dis"}],"container-title":["American Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937802714002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002937802714002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:35:41Z","timestamp":1704731741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002937802714002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0002937802714002"],"URL":"https:\/\/doi.org\/10.1067\/mob.2003.70","relation":{},"ISSN":["0002-9378"],"issn-type":[{"value":"0002-9378","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}