{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:16:02Z","timestamp":1792041362856,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1067\/moe.2000.105334","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:17:12Z","timestamp":1027570632000},"page":"164-170","source":"Crossref","is-referenced-by-count":28,"title":["Direct oral microscopy and its value in diagnosing mucosal lesions"],"prefix":"10.1067","volume":"90","author":[{"given":"G\u00f6ran W.","family":"Gynther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Rozell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Heimdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/moe.2000.105334_bib1","first-page":"144","article-title":"International seminar on oral leukoplakia and associated lesions related to tobacco habits. 1983 June 27-30; Lund University, Malm\u00f6, Sweden","volume":"12","author":"Axell","year":"1984","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1067\/moe.2000.105334_bib2","first-page":"340","article-title":"Precancerous conditions of the oral mucosa. A computer-aided study","volume":"45","author":"Kramer","year":"1969","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1067\/moe.2000.105334_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.14219\/jada.archive.1968.0127","article-title":"Studies in oral leukoplakia: a preliminary report on the period prevalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients","volume":"76","author":"Pindborg","year":"1968","journal-title":"J Am Dent Assoc"},{"key":"10.1067\/moe.2000.105334_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0030-4220(72)90468-9","article-title":"Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia","volume":"33","author":"Mincer","year":"1972","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib5","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0030-4220(76)90099-2","article-title":"Occurrence of epithelial dysplasia in oral leukoplakia. Analysis and follow-up study of 120 cases","volume":"42","author":"B\u00e1n\u00f3czy","year":"1976","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.bdj.4804055","article-title":"The clinical features and risk of malignant transformation in sublingual keratosis","volume":"144","author":"Kramer","year":"1978","journal-title":"Br Dent J"},{"key":"10.1067\/moe.2000.105334_bib7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F","article-title":"Oral leukoplakia and malignant transformation. A follow-up study of 257 patients","volume":"53","author":"Silverman","year":"1984","journal-title":"Cancer"},{"key":"10.1067\/moe.2000.105334_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-0714.1988.tb01527.x","article-title":"Course of various clinical forms of oral lichen planus. A prospective follow-up study of 611 patients","volume":"17","author":"Thorn","year":"1988","journal-title":"J Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0714.1988.tb01528.x","article-title":"Malignant development of lichen planus-affected oral mucosa","volume":"17","author":"Holmstrup","year":"1988","journal-title":"J Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-0714.1995.tb01166.x","article-title":"Observer variability in the histologic assessment of oral premalignant lesions","volume":"24","author":"Karabutul","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"10.1067\/moe.2000.105334_bib11","first-page":"41","article-title":"Diagnosis","author":"Silverman","year":"1990"},{"key":"10.1067\/moe.2000.105334_bib12","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0030-4220(89)90355-1","article-title":"Intraoral application of microcolpohysteroscopy. A new technique for clinical examination of oral tissues at high magnification","volume":"67","author":"L'Estrange","year":"1989","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib13","first-page":"21","article-title":"Terminology and definitions","author":"Kolstad","year":"1982"},{"key":"10.1067\/moe.2000.105334_bib14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/1097-0142(197607)38:1<432::AID-CNCR2820380167>3.0.CO;2-Q","article-title":"Colposcopy","volume":"38","author":"Stafl","year":"1976","journal-title":"Cancer"},{"key":"10.1067\/moe.2000.105334_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-0528.1980.tb04416.x","article-title":"The accuracy of colposcopically directed biopsy in patients with suspected intraepithelial neoplasia of the cervix","volume":"87","author":"Kirkup","year":"1980","journal-title":"Br J Obstet Gynecol"},{"key":"10.1067\/moe.2000.105334_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0028-2243(87)90021-9","article-title":"The accuracy of colposcopically directed biopsy in diagnosis of CIN","volume":"24","author":"Helmerhorst","year":"1987","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1067\/moe.2000.105334_bib17","first-page":"433","article-title":"The accuracy of colposcopically directed biopsy in the diagnosis of cervical intraepithelial neoplasia","volume":"6","author":"Cinel","year":"1990","journal-title":"Eur J Gynaec Oncol"},{"key":"10.1067\/moe.2000.105334_bib18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3109\/00016349709047830","article-title":"An analysis of the factors involved in the diagnostic accuracy of colposcopically directed biopsy","volume":"76","author":"Baldauf","year":"1997","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1067\/moe.2000.105334_bib19","first-page":"33","article-title":"Methods","author":"Kolstad","year":"1982"},{"key":"10.1067\/moe.2000.105334_bib20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/1097-0142(19800815)46:4<758::AID-CNCR2820460420>3.0.CO;2-8","article-title":"Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing prospective study of oral cancer. III","volume":"46","author":"Mashberg","year":"1980","journal-title":"Cancer"},{"key":"10.1067\/moe.2000.105334_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0030-4220(89)90286-7","article-title":"Use of meta-analysis to evaluate tolonium chloride in oral cancer screening","volume":"67","author":"Rosenberg","year":"1989","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1079-2104(97)90117-7","article-title":"The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma","volume":"83","author":"Epstein","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1067\/moe.2000.105334_bib23","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S1079-2104(98)90071-3","article-title":"The application of toluidine blue as diagnostic adjunct in the detection of epithelial dysplasia","volume":"85","author":"Martin","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1067\/moe.2000.105334_bib24","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1001\/jama.1981.03310480024019","article-title":"Tolonium (toluidine blue) rinse: a screening method for the recognition of oral carcinoma","volume":"245","author":"Mashberg","year":"1981","journal-title":"JAMA"},{"key":"10.1067\/moe.2000.105334_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1600-0714.1990.tb00842.x","article-title":"Acetowhite staining and its significance in diagnosis of oral mucosal lesions in women with genital HPV infections","volume":"19","author":"Kellokoski","year":"1990","journal-title":"J Oral Pathol Med"},{"key":"10.1067\/moe.2000.105334_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.14219\/jada.archive.1969.0300","article-title":"Oral cytology: its value and its limitations","volume":"79","author":"Hayes","year":"1969","journal-title":"J Am Dent Assoc"},{"key":"10.1067\/moe.2000.105334_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0030-4220(72)90209-5","article-title":"Oral exfoliative study. Review of the literature and report of a three-year study","volume":"33","author":"Folsom","year":"1972","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1067\/moe.2000.105334_bib28","first-page":"196","article-title":"Cytologic, histologic and clinical correlations of precancerous and cancerous oral lesions in 57,518 industrial workers of Gujarat, India","volume":"21","author":"Silverman","year":"1977","journal-title":"Acta Cytol"},{"key":"10.1067\/moe.2000.105334_bib29","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1079-2104(99)70149-6","article-title":"Toluidine blue\u2014viewpoints","volume":"87","author":"Wysocki","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1067\/moe.2000.105334_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<39::AID-PATH1088>3.0.CO;2-L","article-title":"The association between tumour progression and vascularity in the oral mucosa","volume":"183","author":"Pazouki","year":"1997","journal-title":"J Pathol"},{"key":"10.1067\/moe.2000.105334_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1079-2104(97)90001-9","article-title":"Leukoplakia and malignant transformation","volume":"83","author":"Ephros","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107921040027460X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107921040027460X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:57:35Z","timestamp":1557410255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107921040027460X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S107921040027460X"],"URL":"https:\/\/doi.org\/10.1067\/moe.2000.105334","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}