{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:13:37Z","timestamp":1791094417208,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1067\/mpd.2000.107839","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:15:48Z","timestamp":1027570548000},"page":"338-344","source":"Crossref","is-referenced-by-count":13,"title":["Isolation and identification of the group B streptococcal toxin CM101 from infants with sepsis"],"prefix":"10.1067","volume":"137","author":[{"given":"H\u00e5kan W.","family":"Sundell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint E.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara D.","family":"Wamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanning","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Gaddipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl G.","family":"Hellerqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mpd.2000.107839_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0022-3476(96)70192-0","article-title":"Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network","volume":"129","author":"Stoll","year":"1996","journal-title":"J Pediatr"},{"key":"10.1067\/mpd.2000.107839_bib2","first-page":"980","article-title":"Group B streptococcal infections","author":"Baker","year":"1995"},{"key":"10.1067\/mpd.2000.107839_bib3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1542\/peds.60.6.901","article-title":"Compliment activation and group B streptococcal infection in the newborn. Similarities to endotoxin shock","volume":"60","author":"Fenton","year":"1977","journal-title":"Pediatrics"},{"key":"10.1067\/mpd.2000.107839_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1203\/00006450-197704000-00818","article-title":"Effects of group B streptococci on lung fluid balance in unanesthetized sheep. [abstract]","volume":"11","author":"Stahlman","year":"1977","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1203\/00006450-198106000-00002","article-title":"Studies on group B \u03b2-hemolytic Streptococcus. I. Isolation and partial characterization of an extracellular toxin","volume":"15","author":"Hellerqvist","year":"1981","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1203\/00006450-198106000-00003","article-title":"Studies on group B \u03b2-hemolytic Streptococcus. II. Effects on pulmonary hemodynamics and vascular permeability in unanesthetized sheep","volume":"15","author":"Rojas","year":"1981","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib7","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1152\/jappl.1987.63.5.2024","article-title":"Pulmonary response to group B streptococcal toxin in young lambs","volume":"63","author":"Sandberg","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1067\/mpd.2000.107839_bib8","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1203\/00006450-198312000-00015","article-title":"Pulmonary hemodynamic and ultrastructural changes associated with group B streptococcal toxemia in adult sheep and newborn lambs","volume":"12","author":"Rojas","year":"1983","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1073\/pnas.84.1.51","article-title":"Molecular basis for group B \u03b2-hemolytic streptococcal disease","volume":"84","author":"Hellerqvist","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1067\/mpd.2000.107839_bib10","first-page":"010","article-title":"Therapeutic agent and method of inhibiting vascularization of tumors","volume":"5","author":"Hellerqvist","year":"1991","journal-title":"U.S. Patent"},{"key":"10.1067\/mpd.2000.107839_bib11","first-page":"811","article-title":"Polysaccharide toxin from Group B \u00df-hemolytic streptococcus (GBS) having improved purity","volume":"5","author":"Hellerqvist","year":"1998","journal-title":"U.S. Patent"},{"key":"10.1067\/mpd.2000.107839_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1009258801899","article-title":"Functional studies on the anti-pathoangiogenic properties of CM101","volume":"2","author":"Yan","year":"1998","journal-title":"Angiogenesis"},{"key":"10.1067\/mpd.2000.107839_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1203\/00006450-199405000-00008","article-title":"Thromboxane receptor blockade (SQ 29,548) in group B streptococcal toxin challenge in young lambs","volume":"35","author":"Sandberg","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib14","first-page":"399","article-title":"Immunological and histochemical toxemia in adult sheep and newborn lambs. [abstract]","volume":"6","author":"Russell","year":"1988","journal-title":"Glycoconj J"},{"key":"10.1067\/mpd.2000.107839_bib15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1542\/peds.91.3.617","article-title":"Score for neonatal acute physiology: a physiologic severity index for neonatal intensive care","volume":"91","author":"Richardson","year":"1993","journal-title":"Pediatrics"},{"key":"10.1067\/mpd.2000.107839_bib16","first-page":"58","article-title":"Lung injury by streptococcal toxins","author":"Sundell","year":"1989"},{"key":"10.1067\/mpd.2000.107839_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1021\/bi00376a020","article-title":"Structure of the complex group-specific polysaccharide of Group B Streptococcus","volume":"26","author":"Michon","year":"1987","journal-title":"Biochem J"},{"key":"10.1067\/mpd.2000.107839_bib18","first-page":"557","article-title":"Expression cloning of CM101 receptor gene from mammalian cells. [abstract]","volume":"40","author":"Fu","year":"1999","journal-title":"Proc Am Assoc Cancer Res"},{"key":"10.1067\/mpd.2000.107839_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-198702000-00010","article-title":"The role of granulocytes in the pulmonary response to group B streptococcal toxin in young lambs","volume":"21","author":"Englehardt","year":"1987","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.107839_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF01200726","article-title":"Antitumor effects of GBS toxin: a polysaccharide exotoxin from group B \u03b2-hemolytic streptococcus","volume":"120","author":"Hellerqvist","year":"1993","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1067\/mpd.2000.107839_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF01213551","article-title":"Acute inflammatory changes in subcutaneous microtumors in mice ears induced by intravenous CM101 (GBS toxin)","volume":"122","author":"Thurman","year":"1996","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1067\/mpd.2000.107839_bib22","first-page":"365","article-title":"A phase I study of the antineovascularization drug CM-101","volume":"3","author":"DeVore","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1067\/mpd.2000.107839_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s004320050046","article-title":"Soluble E-Selectin in cancer patients as a marker of the therapeutic efficacy of CM101, a tumor inhibiting agent, evaluated in phase I clinical trial","volume":"123","author":"Wamil","year":"1997","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1067\/mpd.2000.107839_bib24","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-3476(76)80271-5","article-title":"Cerebrospinal fluid evaluation in neonates: comparison of high-risk infants with and without meningitis","volume":"88","author":"Sarff","year":"1976","journal-title":"J Pediatr"},{"key":"10.1067\/mpd.2000.107839_bib25","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1172\/JCI115140","article-title":"Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat","volume":"87","author":"Quagliarello","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1067\/mpd.2000.107839_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/jcm.33.1.193-198.1995","article-title":"Sensitivity and specificity of rapid diagnostic tests for detection of group B streptococcal antigen in bacteremic neonates","volume":"33","author":"Greenberg","year":"1995","journal-title":"J Clin Microbiol"},{"key":"10.1067\/mpd.2000.107839_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0095-5108(18)30528-1","article-title":"Clinicopathologic approach to the diagnosis of neonatal sepsis","volume":"18","author":"Gerdes","year":"1991","journal-title":"Clin Perinatol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347600109382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347600109382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:44:53Z","timestamp":1680533093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347600109382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0022347600109382"],"URL":"https:\/\/doi.org\/10.1067\/mpd.2000.107839","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}