{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:28Z","timestamp":1787241988759,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1067\/mpd.2000.108103","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:15:48Z","timestamp":1027556148000},"page":"386-392","source":"Crossref","is-referenced-by-count":22,"title":["Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy"],"prefix":"10.1067","volume":"137","author":[{"given":"Francesco","family":"Chiarelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariapina","family":"Pomilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Mohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tumini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Vanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Morgese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Verrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mpd.2000.108103_bib1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/bmj.287.6396.867","article-title":"Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whiteall study","volume":"287","author":"Fuller","year":"1983","journal-title":"Br Med J"},{"key":"10.1067\/mpd.2000.108103_bib2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2337\/diacare.15.9.1141","article-title":"Diabetes mellitus and macrovascular complications: an epidemiological perspective","volume":"15","author":"Donahue","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2000.108103_bib3","first-page":"207","article-title":"Vascular thrombosis in diabetes","author":"Colwell","year":"1996"},{"key":"10.1067\/mpd.2000.108103_bib4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/0002-9149(87)91086-1","article-title":"Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus","volume":"59","author":"Krolewski","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1067\/mpd.2000.108103_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00285287","article-title":"Albuminuria reflects widespread vascular damage: the Steno hypothesis","volume":"32","author":"Deckert","year":"1989","journal-title":"Diabetologia"},{"key":"10.1067\/mpd.2000.108103_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2337\/diab.41.6.736","article-title":"Prospective study of microalbuminuria as predictor of mortality in NIDDM","volume":"41","author":"Mattock","year":"1992","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2000.108103_bib7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJM198801213180303","article-title":"Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus","volume":"318","author":"Krolewski","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1067\/mpd.2000.108103_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF00417692","article-title":"LDL subclasses in IDDM patients: relation to diabetic nephropathy","volume":"37","author":"Lahdenpera","year":"1994","journal-title":"Diabetologia"},{"key":"10.1067\/mpd.2000.108103_bib9","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.2337\/diacare.19.12.1382","article-title":"Increased plasma apolipoprotein(a) levels in IDDM patients with diabetic nephropathy","volume":"19","author":"Taranov","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2000.108103_bib10","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/01.ATV.17.5.989","article-title":"Plasma total homocysteine, B vitamin, and risk of coronary atherosclerosis","volume":"17","author":"Verhoef","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1067\/mpd.2000.108103_bib11","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(95)92407-8","article-title":"Prospective study of serum total concentration of homocysteine and risk of stroke in middle-aged British men","volume":"346","author":"Perry","year":"1995","journal-title":"Lancet"},{"key":"10.1067\/mpd.2000.108103_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/01.ATV.16.1.165","article-title":"Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerotic disease","volume":"16","author":"van den Berg","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1067\/mpd.2000.108103_bib13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s001250050969","article-title":"Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: A new link between diabetic nephropathy and cardiovascular disease?","volume":"41","author":"Chico","year":"1998","journal-title":"Diabetologia"},{"key":"10.1067\/mpd.2000.108103_bib14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2337\/diacare.21.5.841","article-title":"Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM","volume":"21","author":"Hofmann","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2000.108103_bib15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2337\/diab.28.12.1039","article-title":"Classification of diabetes mellitus and other categories of glucose intolerance","volume":"28","author":"National Diabetes Data Group","year":"1979","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2000.108103_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0161-6420(84)34336-6","article-title":"Diabetic retinopathy: assessment of severity and progression","volume":"91","author":"Klein","year":"1984","journal-title":"Ophthalmology"},{"key":"10.1067\/mpd.2000.108103_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/clinchem\/41.3.361","article-title":"Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction","volume":"41","author":"Andersson","year":"1995","journal-title":"Clin Chem"},{"key":"10.1067\/mpd.2000.108103_bib18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s001090050079","article-title":"Susceptibility of plasma low- and high-density lipoproteins to oxidation in patients with severe hyperhomocysteinaemia","volume":"74","author":"C\u00f3rdoba-Porras","year":"1996","journal-title":"J Mol Med"},{"key":"10.1067\/mpd.2000.108103_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0021-9150(95)05529-6","article-title":"Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study","volume":"116","author":"Boston","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1067\/mpd.2000.108103_bib20","first-page":"183","article-title":"Plasma homocysteine and cardiovascular disease","author":"Veland","year":"1992"},{"key":"10.1067\/mpd.2000.108103_bib21","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.1997.03540460039030","article-title":"Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project","volume":"277","author":"Graham","year":"1997","journal-title":"JAMA"},{"key":"10.1067\/mpd.2000.108103_bib22","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1067\/mpd.2000.108103_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2362.1995.tb01545.x","article-title":"Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease","volume":"25","author":"van den Berg","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"10.1067\/mpd.2000.108103_bib24","first-page":"S11","article-title":"Plasma homocyst(e)ine and hemostasis: the ARIC Study [abstract]","volume":"89","author":"Schreiner","year":"1994","journal-title":"Circulation"},{"key":"10.1067\/mpd.2000.108103_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0021-9258(18)61082-8","article-title":"The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells","volume":"262","author":"Heinecke","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1067\/mpd.2000.108103_bib26","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.91.14.6369","article-title":"Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis","volume":"91","author":"Tsai","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1067\/mpd.2000.108103_bib27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1056\/NEJM199502023320511","article-title":"Can lowering homocysteine levels reduce cardiovascular risk?","volume":"332","author":"Stampfer","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1067\/mpd.2000.108103_bib28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(89)91365-2","article-title":"Features of endothelial dysfunction in early diabetic nephropathy","volume":"1","author":"Jensen","year":"1989","journal-title":"Lancet"},{"issue":"Suppl 2","key":"10.1067\/mpd.2000.108103_bib29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2337\/diab.41.2.S32","article-title":"Changes in blood coagulation, platelet function and plasminogen-plasmin system in diabetes","volume":"41","author":"Kwaan","year":"1992","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2000.108103_bib30","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2337\/diab.43.8.1010","article-title":"Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM","volume":"43","author":"Tsai","year":"1994","journal-title":"Diabetes"},{"issue":"Suppl 2A","key":"10.1067\/mpd.2000.108103_bib31","first-page":"62S-5S","article-title":"Insulin as a mitogenic factor: role in the pathogenesis of cardiovascular disease","volume":"90","author":"Stout","year":"1991","journal-title":"Am J Med"},{"key":"10.1067\/mpd.2000.108103_bib32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3109\/00365519409087544","article-title":"Lack of association between plasma homocysteine levels and microangiopathy in type 1 diabetes mellitus","volume":"54","author":"Agardh","year":"1994","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1067\/mpd.2000.108103_bib33","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.2337\/diacare.21.11.1843","article-title":"Plasma homocysteine concentrations in patients with type 1 diabetes","volume":"21","author":"Cronin","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2000.108103_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.ki.4495353","article-title":"Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study","volume":"54","author":"Hoogeveen","year":"1998","journal-title":"Kidney Int"},{"key":"10.1067\/mpd.2000.108103_bib35","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0140-6736(05)62327-6","article-title":"Moderate hyperhomocysteinaemia and retinopathy in insulin dependent diabetes","volume":"349","author":"Vaccaro","year":"1997","journal-title":"Lancet"},{"key":"10.1067\/mpd.2000.108103_bib36","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0140-6736(98)05381-1","article-title":"Plasma homocysteine and all-cause mortality in diabetes","volume":"353","author":"Kark","year":"1999","journal-title":"Lancet"},{"key":"10.1067\/mpd.2000.108103_bib37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/00365519709055282","article-title":"Poor metabolic control, early age at onset, and marginal folate deficiency are associated with increasing levels of plasma homocysteine in insulin-dependent diabetes mellitus. A five-year follow-up study","volume":"57","author":"Hultberg","year":"1997","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1067\/mpd.2000.108103_bib38","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1073\/pnas.89.21.10193","article-title":"Homocysteine and other sulfhydryl compound enhance the binding of lipoprotein (a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism","volume":"89","author":"Harpel","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1067\/mpd.2000.108103_bib39","first-page":"3111","article-title":"Inherited disorders of folate transport and metabolism","author":"Rosenblatt","year":"1995"},{"key":"10.1067\/mpd.2000.108103_bib40","doi-asserted-by":"crossref","first-page":"1258S","DOI":"10.1093\/jn\/126.suppl_4.1258S","article-title":"Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Framingham study","volume":"126","author":"Selhub","year":"1996","journal-title":"J Nutr"},{"key":"10.1067\/mpd.2000.108103_bib41","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1172\/JCI119024","article-title":"Determinants and vitamin responsiveness of intermediate hyperhomocysteinaemia (> or = 40 \u03bcmol\/liter)","volume":"98","author":"Guttormensen","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1067\/mpd.2000.108103_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0021-9150(95)05648-3","article-title":"Genetic and nongenetic factors for moderate hyperhomocyst(e)inemia","volume":"119","author":"Kang","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1067\/mpd.2000.108103_bib43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.ATV.14.3.465","article-title":"Treatment of mild hyperhomocysteinaemia","volume":"14","author":"Franken","year":"1994","journal-title":"Arterioscler Thromb"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347600147882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347600147882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:44:51Z","timestamp":1680518691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347600147882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0022347600147882"],"URL":"https:\/\/doi.org\/10.1067\/mpd.2000.108103","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}