{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:05:23Z","timestamp":1769159123186,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2003,5,25]],"date-time":"2003-05-25T00:00:00Z","timestamp":1053820800000},"content-version":"vor","delay-in-days":905,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1067\/mpd.2000.109198","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T00:20:13Z","timestamp":1027556413000},"page":"849-855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A simplified cyclic adenosine monophosphate\u2013mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function"],"prefix":"10.1067","volume":"137","author":[{"given":"Amy","family":"Callen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Diener-West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Zeitlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mpd.2000.109198_bib1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0190-9622(89)70063-3","article-title":"Biology of sweat glands and their disorders. I. Normal sweat gland function","volume":"20","author":"Sato","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1067\/mpd.2000.109198_bib2","first-page":"57","article-title":"Rapid regulation of electrolyte absorption in sweat duct","volume":"140","author":"Reddy","year":"1994","journal-title":"J Membr Biol"},{"key":"10.1067\/mpd.2000.109198_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJM198305193082002","article-title":"Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis","volume":"308","author":"Quinton","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1067\/mpd.2000.109198_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0140-6736(93)91885-P","article-title":"Mild cystic fibrosis and normal or borderline sweat test in patients with the 3849 + 10 kb C \u2192 T mutation","volume":"342","author":"Augarten","year":"1993","journal-title":"Lancet"},{"key":"10.1067\/mpd.2000.109198_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ajmg.1320580411","article-title":"Clinical spectrum in homozygotes and compound heterozygotes inheriting cystic fibrosis mutation 3849 + 10kbC - T: significance for geneticists","volume":"58","author":"Gilbert","year":"1995","journal-title":"Am J Med Genet"},{"key":"10.1067\/mpd.2000.109198_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0140-6736(95)92165-6","article-title":"3849+10 kb C \u2192 T mutation and disease severity in cystic fibrosis","volume":"346","author":"Stern","year":"1995","journal-title":"Lancet"},{"key":"10.1067\/mpd.2000.109198_bib7","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1164\/ajrccm\/151.3_Pt_1.899","article-title":"Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis","volume":"151","author":"Stewart","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1067\/mpd.2000.109198_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1203\/00006450-199106010-00001","article-title":"Beta-adrenergic sweat responses in cystic fibrosis heterozygotes with and without the delta F508 allele","volume":"29","author":"Johnson","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.109198_bib9","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1172\/JCI111385","article-title":"Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro","volume":"73","author":"Sato","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1067\/mpd.2000.109198_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1203\/00006450-198709000-00007","article-title":"Hyposecretion of beta-adrenergically induced sweating in cystic fibrosis heterozygotes","volume":"22","author":"Behm","year":"1987","journal-title":"Pediatr Res"},{"key":"10.1067\/mpd.2000.109198_bib11","first-page":"511","article-title":"Variable reduction in beta-adrenergic sweat secretion in cystic fibrosis heterozygotes","volume":"111","author":"Sato","year":"1988","journal-title":"J Lab Clin Med"},{"key":"10.1067\/mpd.2000.109198_bib12","series-title":"Nonparametric statistics for the behavioral sciences","author":"Siegel","year":"1988"},{"key":"10.1067\/mpd.2000.109198_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/sim.4780040112","article-title":"A Wilcoxon-type test for trend","volume":"4","author":"Cuzick","year":"1985","journal-title":"Stat Med"},{"key":"10.1067\/mpd.2000.109198_bib14","doi-asserted-by":"crossref","first-page":"C486","DOI":"10.1152\/ajpcell.1996.271.2.C486","article-title":"Distinct cellular mechanisms of cholinergic and beta-adrenergic sweat secretion","volume":"271","author":"Reddy","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1067\/mpd.2000.109198_bib15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1542\/peds.23.3.545","article-title":"A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis","volume":"23","author":"Gibson","year":"1959","journal-title":"Pediatrics"},{"key":"10.1067\/mpd.2000.109198_bib16","first-page":"524","article-title":"Sweat chloride concentrations in infants homozygous or heterozygous for F508 cystic fibrosis","volume":"97","author":"Farrell","year":"1996","journal-title":"Pediatrics"},{"key":"10.1067\/mpd.2000.109198_bib17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/hum.1995.6.4-445","article-title":"In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis","volume":"6","author":"Knowles","year":"1995","journal-title":"Hum Gene Ther"},{"key":"10.1067\/mpd.2000.109198_bib18","first-page":"R203","article-title":"Individual variations in structure and function of human eccrine sweat gland","volume":"245","author":"Sato","year":"1983","journal-title":"Am J Physiol"},{"key":"10.1067\/mpd.2000.109198_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0022-3476(98)70441-X","article-title":"Comparison of the clinical manifestations of cystic fibrosis in black and white patients","volume":"132","author":"Hamosh","year":"1998","journal-title":"J Pediatr"},{"key":"10.1067\/mpd.2000.109198_bib20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0272-5231(05)70091-5","article-title":"What is a cystic fibrosis diagnosis?","volume":"19","author":"Rosenstein","year":"1998","journal-title":"Clin Chest Med"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234760097327X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234760097327X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:47:39Z","timestamp":1758358059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234760097327X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S002234760097327X"],"URL":"https:\/\/doi.org\/10.1067\/mpd.2000.109198","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A simplified cyclic adenosine monophosphate\u2013mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1067\/mpd.2000.109198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}