{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:42:51Z","timestamp":1791308571555,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1067\/mpd.2001.109603","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T04:18:43Z","timestamp":1027570723000},"page":"38-44","source":"Crossref","is-referenced-by-count":228,"title":["Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome"],"prefix":"10.1067","volume":"138","author":[{"given":"Vered D.","family":"Lewy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapriel","family":"Danadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma F.","family":"Witchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Arslanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mpd.2001.109603_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1043-2760(98)00020-4","article-title":"Endocrine and metabolic abnormalities in adolescents with a PCOS-like condition: consequences for adult reproduction","volume":"9","author":"Apter","year":"1998","journal-title":"Trends Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0932-8610(19)80155-X","article-title":"Polycystic ovarian syndrome and associated hirsutism in the adolescent","volume":"5","author":"McClamrock","year":"1992","journal-title":"Adolesc Pediatr Gynecol"},{"key":"10.1067\/mpd.2001.109603_bib3","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1210\/jc.81.3.1237","article-title":"Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism","volume":"81","author":"Ibanez","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1043-2760(98)00014-9","article-title":"Insulin resistance, premature adrenarche, and a risk of the polycystic ovary syndrome (PCOS)","volume":"9","author":"Ibanez","year":"1998","journal-title":"Trends Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0015-0282(16)55307-2","article-title":"Puberty and polycystic ovarian syndrome: the insulin\/insulin-like growth factor I hypothesis","volume":"58","author":"Nobels","year":"1992","journal-title":"Fertil Steril"},{"key":"10.1067\/mpd.2001.109603_bib6","first-page":"384","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"Zawadzki","year":"1992"},{"key":"10.1067\/mpd.2001.109603_bib7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/er.18.6.774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endoc Rev"},{"key":"10.1067\/mpd.2001.109603_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diab.38.9.1165","article-title":"Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome","volume":"38","author":"Dunaif","year":"1989","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2001.109603_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/jc.84.1.165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2001.109603_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3928\/0090-4481-19990901-11","article-title":"Type II diabetes mellitus: no longer just adults","volume":"28","author":"Libman","year":"1999","journal-title":"Pediatr Ann"},{"key":"10.1067\/mpd.2001.109603_bib12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2337\/diacare.23.3.381","volume":"23","author":"American Diabetes Association","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2001.109603_bib13","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2337\/diacare.22.8.1325","article-title":"Insulin sensitivity in African-American children with and without family history of type 2 diabetes","volume":"22","author":"Danadian","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1067\/mpd.2001.109603_bib14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0022-3476(96)70078-1","article-title":"Differences in the in vivo insulin secretion and sensitivity in healthy black vs white adolescents","volume":"129","author":"Arslanian","year":"1996","journal-title":"J Pediatr"},{"key":"10.1067\/mpd.2001.109603_bib15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2337\/diab.43.7.908","article-title":"Correlations between fatty acid and glucose metabolism: potential explanation of insulin resistance of puberty","volume":"43","author":"Arslanian","year":"1994","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2001.109603_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0026-0495(98)90262-1","article-title":"Plasma leptin in children: relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure","volume":"47","author":"Arslanian","year":"1998","journal-title":"Metabolism"},{"key":"10.1067\/mpd.2001.109603_bib17","first-page":"E523","article-title":"Glucose-fatty acid interactions in prepubertal and pubertal children: effects of lipid infusion","volume":"272","author":"Arslanian","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mpd.2001.109603_bib18","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1210\/jc.82.10.3213","article-title":"Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism","volume":"82","author":"Arslanian","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJM199608293350902","article-title":"Decreases in ovarian cytochrome P450c17 activity and serum free testosterone after reduction in insulin secretion in women with polycystic ovary syndrome","volume":"335","author":"Nestler","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1067\/mpd.2001.109603_bib20","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1210\/jc.83.6.2001","article-title":"Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system","volume":"83","author":"Nestler","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib21","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1210\/jcem-62-5-904","article-title":"Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism","volume":"62","author":"Barbieri","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2265.1992.tb02909.x","article-title":"Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome","volume":"36","author":"Kiddy","year":"1992","journal-title":"Clin Endocrinol"},{"key":"10.1067\/mpd.2001.109603_bib23","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jcem-68-6-1027","article-title":"Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome","volume":"68","author":"Nestler","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib24","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1210\/jc.81.9.3299","article-title":"The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome","volume":"81","author":"Dunaif","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib25","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1210\/jc.82.7.2108","article-title":"Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome","volume":"82","author":"Ehrmann","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2265.1999.00770.x","article-title":"Ovarian responses to hCG stimulation: insulin resistance\/hyperinsulinemia vs insulin deficiency","volume":"51","author":"Witchel","year":"1999","journal-title":"Clin Endocrinol"},{"key":"10.1067\/mpd.2001.109603_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1210\/jc.79.1.119","article-title":"Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of polycystic ovarian syndrome","volume":"79","author":"Apter","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib28","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/jc.81.3.942","article-title":"\u03b2-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome","volume":"81","author":"Dunaif","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib29","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1210\/jc.76.5.1241","article-title":"Defects in \u03b2-cell function in functional ovarian hyperandrogenism","volume":"76","author":"O\u2019Meara","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib30","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1172\/JCI118064","article-title":"Insulin secretory defects in polycystic ovary syndrome","volume":"96","author":"Ehrmann","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1067\/mpd.2001.109603_bib31","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1210\/jc.80.10.2966","article-title":"Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism","volume":"80","author":"Apter","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib32","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1210\/jc.83.6.1900","article-title":"Ovarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study","volume":"83","author":"Mauras","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1067\/mpd.2001.109603_bib33","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2337\/diab.37.6.667","article-title":"Lilly Lecture 1987. The triumvirate: b cell, muscle, liver - a collision responsible for NIDDM","volume":"37","author":"DeFronzo","year":"1988","journal-title":"Diabetes"},{"key":"10.1067\/mpd.2001.109603_bib34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0889-8529(05)70098-0","article-title":"Type 2 diabetes mellitus in minority children and adolescents: an emerging problem","volume":"28","author":"Dabelea","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1067\/mpd.2001.109603_bib35","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1210\/jc.83.8.2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome","volume":"83","author":"Legro","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347601602804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347601602804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:52:50Z","timestamp":1557409970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347601602804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0022347601602804"],"URL":"https:\/\/doi.org\/10.1067\/mpd.2001.109603","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}