{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:37:45Z","timestamp":1771591065383,"version":"3.50.1"},"reference-count":8,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1067\/msy.2000.104166","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T17:01:17Z","timestamp":1066410077000},"page":"589-592","source":"Crossref","is-referenced-by-count":8,"title":["Recombinant granulocyte macrophage colony stimulating factor (rhu-GM-CSF) in the treatment of extensive leg ulcers: A case report"],"prefix":"10.1016","volume":"127","author":[{"given":"Furqan H.","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Joseph J.","family":"Biundo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleveland","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Ermita\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro P.","family":"Ortigas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"DeFrancesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/msy.2000.104166_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0002-9610(97)89589-X","article-title":"Double blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers","volume":"173","author":"Marques da Costa","year":"1997","journal-title":"Am J Surg"},{"key":"10.1067\/msy.2000.104166_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1524-475X.1999.00017.x","article-title":"Randomized, double blind, placebo-controlled, dose-ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers","volume":"7","author":"Marques Da Costa","year":"1999","journal-title":"Wound Repair Regen"},{"key":"10.1067\/msy.2000.104166_bib3","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.175.6.1717","article-title":"Novel responses of human skin to intradermal recombinant GM-CSF: Langerhans' cell recruitment, keratinocyte growth and enhanced wound healing","volume":"175","author":"Kaplan","year":"1992","journal-title":"J Exp Med"},{"key":"10.1067\/msy.2000.104166_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02899267","article-title":"GM-CSF-induced granulation tissue formation: relationships between macrophage and myofibroblast accumulation","volume":"63","author":"Vyalov","year":"1993","journal-title":"Virchows Archiv B Cell Pathol Incl Mol Pathol"},{"key":"10.1067\/msy.2000.104166_bib5","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.168.4.1395","article-title":"Keratinocyte growth regulation by the products of immune cells","volume":"168","author":"Hancock","year":"1988","journal-title":"J Exp Med"},{"key":"10.1067\/msy.2000.104166_bib6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/1523-1747.ep12396936","article-title":"GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo","volume":"103","author":"Braunstein","year":"1994","journal-title":"J Invest Dermatol"},{"issue":"Suppl. 2","key":"10.1067\/msy.2000.104166_bib7","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1007\/BF01973601","article-title":"Effects of granulocyte-macrophage colony-stimulating factor on wound contraction","volume":"13","author":"Robson","year":"1994","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1067\/msy.2000.104166_bib8","first-page":"325","article-title":"Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: differential action on incisional wound healing","volume":"115","author":"Jyung","year":"1994","journal-title":"Surgery"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606000926436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606000926436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T15:22:54Z","timestamp":1550589774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606000926436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0039606000926436"],"URL":"https:\/\/doi.org\/10.1067\/msy.2000.104166","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}