{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:40:05Z","timestamp":1769186405547,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":5361,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1067\/mtc.2001.116314","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T22:14:26Z","timestamp":1030227266000},"page":"946-954","source":"Crossref","is-referenced-by-count":45,"title":["Mechanisms of aortic valve incompetence: Finite-element modeling of Marfan syndrome"],"prefix":"10.25013","volume":"122","author":[{"given":"K.Jane","family":"Grande-Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per G.","family":"Reinhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyn S.","family":"Kunzelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1067\/mtc.2001.116314_bib1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1056\/NEJM197904053001406","article-title":"The Marfan syndrome: diagnosis and management","volume":"300","author":"Pyeritz","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1067\/mtc.2001.116314_bib2","first-page":"51","article-title":"The Marfan syndrome","author":"Godfrey","year":"1993"},{"key":"10.1067\/mtc.2001.116314_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome cuased by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"10.1067\/mtc.2001.116314_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0950-821X(05)80597-3","article-title":"Abnormal mechanical properties of the aorta in Marfan's syndrome","volume":"8","author":"Sonesson","year":"1994","journal-title":"Eur J Vasc Surg"},{"key":"10.1067\/mtc.2001.116314_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0002-9149(62)90066-8","article-title":"Cardiovascular system in Marfan's syndrome and in idiopathic dilatation of the ascending aorta","volume":"9","author":"Wagenvoort","year":"1962","journal-title":"Am J Cardiol"},{"key":"10.1067\/mtc.2001.116314_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.5694\/j.1326-5377.1993.tb121876.x","article-title":"The natural history of aortic dilatation in Marfan syndrome","volume":"158","author":"Hwa","year":"1993","journal-title":"Med J Aust"},{"key":"10.1067\/mtc.2001.116314_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0039-6109(16)44876-0","article-title":"Pathophysiology and pathogenesis of aortic aneurysms. Current concepts","volume":"69","author":"Dobrin","year":"1989","journal-title":"Surg Clin North Am"},{"key":"10.1067\/mtc.2001.116314_bib8","first-page":"71","article-title":"Management of aortic valve incompetence in patients with Marfan syndrome","author":"Yacoub","year":"1995"},{"key":"10.1067\/mtc.2001.116314_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0002-8703(82)90650-0","article-title":"The spectrum of cardiovascular disease in the Marfan syndrome: a clinico-morphologic study of 18 necropsy patients and comparison to 151 previously reported necropsy patients","volume":"104","author":"Roberts","year":"1982","journal-title":"Am Heart J"},{"key":"10.1067\/mtc.2001.116314_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0003-4975(10)60554-1","article-title":"Stress sharing between the sinus and leaflets of canine aortic valve","volume":"42","author":"Thubrikar","year":"1986","journal-title":"Ann Thorac Surg"},{"key":"10.1067\/mtc.2001.116314_bib11","first-page":"23","article-title":"The fluid mechanics of the aortic valve","author":"Bellhouse","year":"1972"},{"key":"10.1067\/mtc.2001.116314_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1114\/1.122","article-title":"Stress variations in the human aortic root and valve: the role of anatomic symmetry","volume":"26","author":"Grande","year":"1998","journal-title":"Ann Biomed Eng"},{"key":"10.1067\/mtc.2001.116314_bib13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0021-9290(94)00091-H","article-title":"Longitudinal strain of canine and porcine aortas","volume":"28","author":"Han","year":"1995","journal-title":"J Biomech"},{"key":"10.1067\/mtc.2001.116314_bib14","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0003-4975(00)01307-2","article-title":"Mechanisms of aortic valve incompetence: finite element modeling of aortic root dilatation","volume":"69","author":"Grande-Allen","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1067\/mtc.2001.116314_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/hrt.75.4.389","article-title":"Aortic root complications in Marfan's syndrome: identification of a lower risk group","volume":"75","author":"Legget","year":"1995","journal-title":"Heart"},{"key":"10.1067\/mtc.2001.116314_bib16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0022-5223(19)41751-0","article-title":"Scanning and light microscopy of human aortic leaflets in stressed and relaxed states","volume":"67","author":"Clark","year":"1974","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1067\/mtc.2001.116314_bib17","first-page":"65","article-title":"Vascular mechanics","volume":"Vol. 3","author":"Dobrin","year":"1983"},{"key":"10.1067\/mtc.2001.116314_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF02484469","article-title":"Non-invasive assessment of aortic mechanical properties","volume":"14","author":"Kalath","year":"1986","journal-title":"Ann Biomed Eng"},{"key":"10.1067\/mtc.2001.116314_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0021-9290(92)90249-Z","article-title":"Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets","volume":"25","author":"Vesely","year":"1992","journal-title":"J Biomech"},{"key":"10.1067\/mtc.2001.116314_bib20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1115\/1.3138405","article-title":"Poisson's ratio and incompressibility","volume":"105","author":"Vawter","year":"1983","journal-title":"J Biomech Eng"},{"key":"10.1067\/mtc.2001.116314_bib21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0021-9290(89)90016-X","article-title":"Analysis of the bending behaviour of porcine xenograft leaflets and of neutral aortic valve material: bending stiffness, neutral axis and shear measurements","volume":"22","author":"Vesely","year":"1989","journal-title":"J Biomech"},{"key":"10.1067\/mtc.2001.116314_bib22","series-title":"Biomechanics: mechanical properties of living tissues","author":"Fung","year":"1993"},{"key":"10.1067\/mtc.2001.116314_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0003-4975(10)61845-0","article-title":"Mechanical stresses on closed cusps of porcine bioprosthetic valves: correlation with sites of calcification","volume":"42","author":"Sabbah","year":"1986","journal-title":"Ann Thorac Surg"},{"key":"10.1067\/mtc.2001.116314_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1010-7940(96)80289-2","article-title":"The Marfan syndrome and the cardiovascular surgeon","volume":"10","author":"Gott","year":"1996","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1067\/mtc.2001.116314_bib25","first-page":"25","article-title":"Cardiovascular pathology in Marfan syndrome\u2014an overview","author":"Becker","year":"1995"}],"container-title":["The Journal of Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522301321797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022522301321797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:44:06Z","timestamp":1620002646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022522301321797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0022522301321797"],"URL":"https:\/\/doi.org\/10.1067\/mtc.2001.116314","relation":{},"ISSN":["0022-5223"],"issn-type":[{"value":"0022-5223","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}