{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:14:39Z","timestamp":1791123279111,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4246,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1067\/mva.2001.117152","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T22:14:26Z","timestamp":1030227266000},"page":"1103-1110","source":"Crossref","is-referenced-by-count":99,"title":["Mitochondrial function and oxygen supply in normal and in chronically ischemic muscle: A combined 31P magnetic resonance spectroscopy and near infrared spectroscopy study in vivo"],"prefix":"10.1067","volume":"34","author":[{"given":"G.J.","family":"Kemp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.E.","family":"Bimson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bakran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.L.","family":"Gilling-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Frostick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1067\/mva.2001.117152_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1358836X0000500109","article-title":"Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease","volume":"5","author":"Brass","year":"2000","journal-title":"Vasc Med"},{"key":"10.1067\/mva.2001.117152_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1067\/mva.2000.102848","article-title":"Expression of myosin heavy chain isoforms in skeletal muscle of patients with peripheral arterial occlusive disease","volume":"31","author":"Steinacker","year":"2000","journal-title":"J Vasc Surg"},{"key":"10.1067\/mva.2001.117152_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/01.CIR.99.6.807","article-title":"Skeletal muscle mitochondrial DNA injury in patients with unilateral peripheral arterial disease","volume":"99","author":"Bhat","year":"1999","journal-title":"Circulation"},{"key":"10.1067\/mva.2001.117152_bib4","first-page":"397","article-title":"Lactate and pyruvate changes in the leg during and after exercise in normal subjects and in patients with femoral artery occlusion","volume":"34","author":"Hlavova","year":"1968","journal-title":"Clin Sci"},{"key":"10.1067\/mva.2001.117152_bib5","first-page":"265","article-title":"Leg blood flow and muscle metabolism in occlusive arterial disease of the leg before and after reconstructive surgery","volume":"49","author":"Pernow","year":"1975","journal-title":"Clin Sci Mol Med"},{"key":"10.1067\/mva.2001.117152_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/bj2000247","article-title":"Energy metabolism in relation to oxygen partial pressure in human skeletal muscle during exercise","volume":"200","author":"Bylund-Fellenius","year":"1981","journal-title":"Biochem J"},{"key":"10.1067\/mva.2001.117152_bib7","doi-asserted-by":"crossref","first-page":"C548","DOI":"10.1152\/ajpcell.1988.254.4.C548","article-title":"A linear model of muscle respiration explains monoexponential phosphocreatine changes","volume":"254","author":"Meyer","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1067\/mva.2001.117152_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/cs0890581","article-title":"Calf muscle mitochondrial and glycogenolytic ATP synthesis in patients with claudication due to peripheral vascular disease analyzed using 31P magnetic resonance spectroscopy","volume":"89","author":"Kemp","year":"1995","journal-title":"Clin Sci"},{"key":"10.1067\/mva.2001.117152_bib9","doi-asserted-by":"crossref","first-page":"C485","DOI":"10.1152\/ajpcell.1997.272.2.C485","article-title":"Acidosis has no effect on the ATP cost of contraction in cat fast- and slow-twitch skeletal muscles","volume":"272","author":"Harkema","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mva.2001.117152_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/heart.83.2.161","article-title":"Dissociation between muscle metabolism and oxygen kinetics during recovery from exercise in patients with chronic heart failure","volume":"83","author":"Hanada","year":"2000","journal-title":"Heart"},{"key":"10.1067\/mva.2001.117152_bib11","first-page":"125","article-title":"Assessment of the efficacy of vasodilator drugs in peripheral vascular disease through a study of skeletal muscle metabolism using 31P nuclear magnetic resonance (NMR) spectroscopy","volume":"47","author":"Wahl","year":"1992","journal-title":"Therapie"},{"key":"10.1067\/mva.2001.117152_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0735-1097(86)80338-2","article-title":"Detection of skeletal muscle hypoperfusion during exercise using phosphorus-31 nuclear magnetic resonance spectroscopy","volume":"7","author":"Wiener","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"10.1067\/mva.2001.117152_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/cs0710283","article-title":"Muscle metabolism in patients with peripheral vascular disease investigated by 31P nuclear magnetic resonance spectroscopy","volume":"71","author":"Hands","year":"1986","journal-title":"Clin Sci"},{"key":"10.1067\/mva.2001.117152_bib14","first-page":"411","article-title":"31P nuclear magnetic resonance spectroscopy: noninvasive biochemical analysis of the ischemic extremity","volume":"3","author":"Zatina","year":"1986","journal-title":"J Vasc Surg"},{"key":"10.1067\/mva.2001.117152_bib15","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1067\/mva.2000.106421","article-title":"Phosphorus 31 nuclear magnetic resonance spectroscopy suggests a mitochondrial defect in claudicating skeletal muscle","volume":"31","author":"Pipinos","year":"2000","journal-title":"J Vasc Surg"},{"key":"10.1067\/mva.2001.117152_bib16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00004424-199711000-00001","article-title":"Dynamic phosphorus-31 magnetic resonance spectroscopy in arterial occlusive disease: correlation with clinical and angiographic findings and comparison to healthy volunteers","volume":"32","author":"Schunk","year":"1997","journal-title":"Invest Radiol"},{"key":"10.1067\/mva.2001.117152_bib17","doi-asserted-by":"crossref","first-page":"B128","DOI":"10.1093\/geronj\/49.3.B128","article-title":"Exercise-induced changes in oxygen saturation in the calf muscles of elderly subjects with peripheral vascular disease","volume":"49","author":"McCully","year":"1994","journal-title":"J Gerontol"},{"key":"10.1067\/mva.2001.117152_bib18","doi-asserted-by":"crossref","first-page":"B159","DOI":"10.1093\/gerona\/52A.3.B159","article-title":"Identification of peripheral vascular disease in elderly subjects using optical spectroscopy","volume":"52","author":"McCully","year":"1997","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1067\/mva.2001.117152_bib19","first-page":"44","article-title":"Noninvasive quantification of muscle oxygen in subjects with and without claudication","volume":"34","author":"Lee","year":"1997","journal-title":"J Rehabil Res Dev"},{"key":"10.1067\/mva.2001.117152_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/1522-2586(200009)12:3<467::AID-JMRI13>3.0.CO;2-G","article-title":"Estimation of body composition in muscular dystrophy by MRI and stereology","author":"Gong","year":"2000","journal-title":"J Magn Reson Imaging"},{"key":"10.1067\/mva.2001.117152_bib21","doi-asserted-by":"crossref","first-page":"7276","DOI":"10.1016\/S0021-9258(19)43389-9","article-title":"Determination of the intracellular pH by 31P magnetic resonance","volume":"248","author":"Moon","year":"1973","journal-title":"J Biol Chem"},{"key":"10.1067\/mva.2001.117152_bib22","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1042\/bst0280100","article-title":"Studying metabolic regulation in human muscle","volume":"28","author":"Kemp","year":"2000","journal-title":"Biochem Soc Trans"},{"key":"10.1067\/mva.2001.117152_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mrm.1910330504","article-title":"ATP production and mechanical work in exercising skeletal muscle: a theoretical analysis applied to 31P magnetic resonance spectroscopic studies of dialysed uraemic patients","volume":"30","author":"Kemp","year":"1995","journal-title":"Magn Reson Med"},{"key":"10.1067\/mva.2001.117152_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1993.sp019673","article-title":"Separate measures of ATP utilization and recovery in human skeletal muscle [published erratum appears in J Physiol 1994 Mar 15;475:548]","volume":"465","author":"Blei","year":"1993","journal-title":"J Physiol"},{"key":"10.1067\/mva.2001.117152_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1085\/jgp.79.1.147","article-title":"Chemical energetics of slow- and fast-twitch muscle of the mouse","volume":"79","author":"Crow","year":"1982","journal-title":"J Gen Physiol"},{"key":"10.1067\/mva.2001.117152_bib26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1113\/jphysiol.1995.sp021013","article-title":"The metabolic costs of different types of contractile activity of the human adductor pollicis muscle","volume":"488","author":"Newham","year":"1995","journal-title":"J Physiol"},{"key":"10.1067\/mva.2001.117152_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1152\/jappl.1997.83.3.867","article-title":"Efficiency of human skeletal muscle in vivo: comparison of isometric, concentric, and eccentric muscle action","volume":"83","author":"Ryschon","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1139\/y88-024","article-title":"Energy cost and metabolic regulation during intermittent and continuous tetanic contractions in human skeletal muscle","volume":"66","author":"Spriet","year":"1988","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1067\/mva.2001.117152_bib29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/nbm.1940060106","article-title":"Energy cost of twitch and tetanic contractions of rat muscle estimated in situ by gated 31P NMR","volume":"6","author":"Foley","year":"1993","journal-title":"NMR Biomed"},{"key":"10.1067\/mva.2001.117152_bib30","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1152\/jappl.1995.78.6.2131","article-title":"Skeletal muscle mitochondrial function studied by kinetic analysis of postexercise phosphocreatine resynthesis","volume":"78","author":"Thompson","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1113\/jphysiol.1990.sp018000","article-title":"Anaerobic energy production and O2 deficit-debt relationship during exhaustive exercise in humans","volume":"422","author":"Bangsbo","year":"1990","journal-title":"J Physiol"},{"key":"10.1067\/mva.2001.117152_bib32","doi-asserted-by":"crossref","first-page":"C491","DOI":"10.1152\/ajpcell.1997.272.2.C491","article-title":"Effect of acidosis on control of respiration in skeletal muscle","volume":"272","author":"Harkema","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1067\/mva.2001.117152_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/nbm.1940060111","article-title":"Control of phosphocreatine resynthesis during recovery from exercise in human skeletal muscle","volume":"6","author":"Kemp","year":"1993","journal-title":"NMR Biomed"},{"key":"10.1067\/mva.2001.117152_bib34","first-page":"43","article-title":"Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review","volume":"10","author":"Kemp","year":"1994","journal-title":"Magn Reson Q"},{"key":"10.1067\/mva.2001.117152_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/jtbi.1994.1184","article-title":"Interactions of mitochondrial ATP synthesis and the creatine kinase equilibrium in skeletal muscle","volume":"170","author":"Kemp","year":"1994","journal-title":"J Theor Biol"},{"key":"10.1067\/mva.2001.117152_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-5793(90)80472-U","article-title":"Heterogeneity of metabolic response to muscular exercise in humans: new criteria of invariance defined by in vivo phosphorus-31 NMR spectroscopy","volume":"272","author":"Bendahan","year":"1990","journal-title":"FEBS Lett"},{"key":"10.1067\/mva.2001.117152_bib37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF02592248","article-title":"Influence of cytosolic pH on in vivo assessment of human muscle mitochondrial respiration by 31P-MRS","volume":"5","author":"Lodi","year":"1997","journal-title":"MAGMA"},{"key":"10.1067\/mva.2001.117152_bib38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/jappl.1993.75.2.813","article-title":"Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles","volume":"75","author":"McCully","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/jappl.1994.77.1.5","article-title":"Simultaneous in vivo measurements of HbO2 saturation and PCr kinetics after exercise in normal humans","volume":"77","author":"McCully","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1152\/jappl.1997.83.3.875","article-title":"Normalized metabolic stress for 31P-MR spectroscopy studies of human skeletal muscle: MVC vs","volume":"83","author":"Fowler","year":"1997","journal-title":"muscle volume. J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1145::AID-MRM10>3.0.CO;2-W","article-title":"31P MRS studies of exercising human muscle at high temporal resolution","volume":"41","author":"Boska","year":"1999","journal-title":"Magn Reson Med"},{"key":"10.1067\/mva.2001.117152_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.CIR.87.2.413","article-title":"Chronic changes in skeletal muscle histology and function in peripheral arterial disease","volume":"87","author":"Regensteiner","year":"1993","journal-title":"Circulation"},{"key":"10.1067\/mva.2001.117152_bib43","first-page":"47","article-title":"Correlation of function and energy metabolism in rat ischemic skeletal muscle by 31P-NMR spectroscopy: effects of torbafylline","volume":"24","author":"Koch","year":"1993","journal-title":"J Med"},{"key":"10.1067\/mva.2001.117152_bib44","first-page":"E400","article-title":"Metabolic responses of canine gracilis muscle during contraction with partial ischemia","volume":"270","author":"Timmons","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1067\/mva.2001.117152_bib45","first-page":"E63","article-title":"Metabolic adaptation to reduced muscle blood flow, I: enzyme and metabolite alterations","volume":"249","author":"Elander","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1067\/mva.2001.117152_bib46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3109\/01913128009140552","article-title":"Intermittent claudication and muscle fibre fine structure: morphometric data on mitochondrial volumes","volume":"1","author":"Anquist","year":"1980","journal-title":"Ultrastruct Pathol"},{"key":"10.1067\/mva.2001.117152_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/cs0690153","article-title":"Biochemical and morphometric properties of mitochondrial populations in human muscle fibres","volume":"69","author":"Elander","year":"1985","journal-title":"Clin Sci"},{"key":"10.1067\/mva.2001.117152_bib48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/cs0770485","article-title":"Muscle enzyme adaptation in patients with peripheral arterial insufficiency: spontaneous adaptation, effect of different treatments and consequences on walking performance","volume":"77","author":"Lundgren","year":"1989","journal-title":"Clin Sci"},{"key":"10.1067\/mva.2001.117152_bib49","first-page":"17","article-title":"Calf muscle adaptation in intermittent claudication","volume":"8","author":"Jansson","year":"1988","journal-title":"Side-differences in muscle metabolic characteristics in patients with unilateral arterial disease. Clin Physiol"},{"key":"10.1067\/mva.2001.117152_bib50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1152\/jappl.1996.81.2.780","article-title":"Effect of exercise training on skeletal muscle histology and metabolism in peripheral arterial disease","volume":"81","author":"Hiatt","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2362.1972.tb00657.x","article-title":"Metabolic activity in human skeletal muscle","volume":"2","author":"Holm","year":"1972","journal-title":"Effect of peripheral arterial insufficiency. Eur J Clin Invest"},{"key":"10.1067\/mva.2001.117152_bib52","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/00365518009092656","article-title":"Enzyme activities, fibre types and capillarization in calf muscles of patients with intermittent claudication","volume":"40","author":"Henriksson","year":"1980","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1067\/mva.2001.117152_bib53","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/cvr\/19.8.507","article-title":"Calf muscle adaptation to peripheral vascular disease","volume":"19","author":"Clyne","year":"1985","journal-title":"Cardiovasc Res"},{"key":"10.1067\/mva.2001.117152_bib54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s004210050553","article-title":"Relationships between muscle mitochondrial DNA content, mitochondrial enzyme activity and oxidative capacity in man: alterations with disease","volume":"80","author":"Wang","year":"1999","journal-title":"Eur J Appl Physiol"},{"key":"10.1067\/mva.2001.117152_bib55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0950-821X(89)80067-2","article-title":"Fibre loss and distribution in skeletal muscle from patients with severe peripheral arterial insufficiency","volume":"3","author":"Hedberg","year":"1989","journal-title":"Eur J Vasc Surg"},{"key":"10.1067\/mva.2001.117152_bib56","first-page":"658","article-title":"Histochemical changes in striated muscle in patients with intermittent claudication","volume":"101","author":"Mackitie","year":"1977","journal-title":"Arch Pathol Lab Med"},{"key":"10.1067\/mva.2001.117152_bib57","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2362.1980.tb00037.x","article-title":"Capillary supply and muscle fibre types in patients with intermittent claudication: relationships between morphology and metabolism","volume":"10","author":"Hammarsten","year":"1980","journal-title":"Eur J Clin Invest"},{"key":"10.1067\/mva.2001.117152_bib58","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1097-4598(199802)21:2<201::AID-MUS7>3.0.CO;2-F","article-title":"Altered surface myoelectric signals in peripheral vascular disease: correlations with muscle fiber composition","volume":"21","author":"Pedrinelli","year":"1998","journal-title":"Muscle Nerve"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521401492494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521401492494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:51:25Z","timestamp":1620003085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521401492494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0741521401492494"],"URL":"https:\/\/doi.org\/10.1067\/mva.2001.117152","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}