{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:45:22Z","timestamp":1765781122182,"version":"3.48.0"},"reference-count":21,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":1166,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the burden of disease and hospitalisation costs in children with common infections using statewide administrative data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed hospitalisation prevalence and costs for 10 infections: appendicitis, cellulitis, cervical lymphadenitis, meningitis, osteomyelitis, pneumonia, pyelonephritis, sepsis, septic arthritis, and urinary tract infections in children aged &amp;lt;18 years admitted to hospital within New South Wales, Australia, using an activity-based management administrative dataset over three financial years (1 July 2016\u201330 June 2019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 339 077 admissions, 28 748 (8.48%) were coded with one of the 10 infections, associated with a total hospitalisation cost of AUD230 905 190 and a per episode median length-of-stay of 3 bed-days. Pneumonia was the most prevalent coded infection (3.1% [n = 10 524] of all admissions), followed by appendicitis (1.61%; n = 5460), cellulitis (1.22%; n = 4126) and urinary tract infections (0.94%; n = 3193). Eighty per cent of children (n = 22 529) were admitted to a non-paediatric hospital. Mean costs were increased 1.18-fold per additional bed-day, 2.14-fold with paediatric hospital admissions, and 5.49-fold with intensive care unit admissions, which were both also associated with greater total bed-day occupancy. Indigenous children comprised 9.7% of children admitted with these infections, and mean per episode costs, and median bed-days were reduced compared with non-Indigenous children (0.84 [95% CI 0.78, 0.89] and 3 (IQR: 2,5) vs 2 (IQR: 2,4), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infections in children requiring hospitalisation contribute\u00a0a substantial burden of disease and cost to the community. This varies by infection, facility type, and patient demographics, and this information should be used to inform and prioritise programs to improve care for children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/ah21360","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T21:59:16Z","timestamp":1654552756000},"page":"471-477","source":"Crossref","is-referenced-by-count":0,"title":["Disease and economic burden of infections in hospitalised children in New South Wales, Australia"],"prefix":"10.1071","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-3416","authenticated-orcid":true,"given":"Brendan J.","family":"McMullan","sequence":"first","affiliation":[{"name":"ASchool of Women\u2019s and Children\u2019s Health, UNSW Sydney, Sydney, NSW, Australia."},{"name":"BDepartment of Immunology and Infectious Diseases, Sydney Children\u2019s Hospital, Randwick, Sydney, NSW, Australia."},{"name":"CNational Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake C.","family":"Valentine","sequence":"additional","affiliation":[{"name":"CNational Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia."},{"name":"DSir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Vic., Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hall","sequence":"additional","affiliation":[{"name":"CNational Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia."},{"name":"ESchool of Public Health, University of Queensland, Brisbane, Qld, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Thursky","sequence":"additional","affiliation":[{"name":"CNational Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Vic., 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