{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:11:04Z","timestamp":1761707464884,"version":"build-2065373602"},"reference-count":32,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":6951,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,25]]},"abstract":"<jats:p>In mammals, pregnancy induces a transient and extensive degeneration of uterine sympathetic innervation. We used the models of unilateral oviduct ligation and in oculo myometrium transplant in pregnant rats to address the role of stretching forces and\/or hormone milieu in the loss of sympathetic innervation. The sympathetic fibres of the uterine horn and in oculo myometrial transplants were quantified on tissue sections processed by the glyoxylic acid technique. In normal pregnant rats, the density of uterine horn innervation was significantly reduced at late pregnancy and recovery took place during post partum. The empty horn of pregnant rats showed no significant changes in density of myometrial innervation during pregnancy or post partum. In oculo myometrial transplants were organotypically reinnervated in virgin animals. When the transplants were exposed to gestational hormonal milieu, few or no fibres were observed to the end of pregnancy; however, a significant increase at post partum was observed. Results showed that both the effects of stretching and the hormone milieu derived from the fetus\u2013placenta complex play a role as inductors of changes on sympathetic myometrial innervation during pregnancy and support the idea that immature muscular uterine fibres are more susceptible to the effects of pregnancy than those originating from adult animals.<\/jats:p>","DOI":"10.1071\/rd05053","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T21:07:08Z","timestamp":1148504828000},"page":"525-531","source":"Crossref","is-referenced-by-count":14,"title":["A quantitative study of rat uterine sympathetic innervation during pregnancy and post partum"],"prefix":"10.1071","volume":"18","author":[{"given":"R.","family":"Ch\u00e1vez-Genaro","sequence":"first","affiliation":[{"name":"ADepartamento de Histolog\u00eda y Embriolog\u00eda, Facultad de Medicina, General Flores 2125, CP 11800, Montevideo, Uruguay."},{"name":"DCorresponding author. Email: rchavez@fmed.edu.uy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lombide","sequence":"additional","affiliation":[{"name":"ADepartamento de Histolog\u00eda y Embriolog\u00eda, Facultad de Medicina, General Flores 2125, CP 11800, Montevideo, Uruguay."},{"name":"BSecci\u00f3n Biolog\u00eda Celular, Departamento de Biolog\u00eda Celular y Molecular, Instituto de Biolog\u00eda, Facultad de Ciencias, Igu\u00e1 4245, CP 11400, Montevideo, Uruguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Anesetti","sequence":"additional","affiliation":[{"name":"ADepartamento de Histolog\u00eda y Embriolog\u00eda, Facultad de Medicina, General Flores 2125, CP 11800, Montevideo, Uruguay."},{"name":"CArea de Histolog\u00eda y Embriolog\u00eda, Facultad de Veterinaria, Las Places 1550, CP 11600, Montevideo, Uruguay."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2006,5,16]]},"reference":[{"key":"2025102818174367000_R1"},{"key":"2025102818174367000_R2"},{"key":"2025102818174367000_R3"},{"key":"2025102818174367000_R4"},{"key":"2025102818174367000_R5"},{"key":"2025102818174367000_R6"},{"key":"2025102818174367000_R7"},{"key":"2025102818174367000_R8"},{"key":"2025102818174367000_R9"},{"key":"2025102818174367000_R10"},{"key":"2025102818174367000_R11"},{"key":"2025102818174367000_R12"},{"key":"2025102818174367000_R13"},{"key":"2025102818174367000_R14"},{"key":"2025102818174367000_R15"},{"key":"2025102818174367000_R16"},{"key":"2025102818174367000_R17"},{"key":"2025102818174367000_R18"},{"key":"2025102818174367000_R19"},{"key":"2025102818174367000_R20"},{"key":"2025102818174367000_R21"},{"key":"2025102818174367000_R22"},{"key":"2025102818174367000_R23"},{"key":"2025102818174367000_R24"},{"key":"2025102818174367000_R25"},{"key":"2025102818174367000_R26"},{"key":"2025102818174367000_R27"},{"key":"2025102818174367000_R28"},{"key":"2025102818174367000_R29"},{"key":"2025102818174367000_R30"},{"key":"2025102818174367000_R31"},{"key":"2025102818174367000_R32"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/18\/5\/525\/299272\/rd05053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/18\/5\/525\/299272\/rd05053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:17:50Z","timestamp":1761689870000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/18\/5\/525\/48096\/A-quantitative-study-of-rat-uterine-sympathetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,16]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5,25]]}},"URL":"https:\/\/doi.org\/10.1071\/rd05053","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"type":"print","value":"1031-3613"},{"type":"electronic","value":"1448-5990"}],"subject":[],"published":{"date-parts":[[2006,5,16]]}}}