{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:46:57Z","timestamp":1761709617881,"version":"build-2065373602"},"reference-count":42,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":6644,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,19]]},"abstract":"<jats:p>In the present study, the possible mechanisms by which interferon (IFN)-? affects pregnancy were investigated using the cytokine network model. The IFN-?-induced expression of interleukin (IL)-1\u00df was examined using western blotting, immunohistochemistry and immunofluorescence. The results showed that IFN-? treatment significantly decreased the expression of uterine IL-1\u00df protein during the preimplantation, post-implantation and mid-gestation periods. The expression of IL-1\u00df protein was increased after IFN-? treatment compared with the control group in late pregnancy. In the placenta, IL-1\u00df protein levels were significantly increased after IFN-? treatment in early and mid-pregnancy. In late pregnancy, IFN-? treatment significantly decreased placental IL-1\u00df protein levels. IL-1\u00df was mainly expressed in the myometrium, uterine arteries, decidua basalis, trophospongium of the junctional layer and trophoblastic epithelium of the labyrinthine layers. IL-1\u00df was mainly located in the cytoplasm of in vitro cultured endometrial stromal cells (ESCs). IFN-? treatment did not affect the distribution of IL-1\u00df, only the expression of IL-1\u00df. The effects of IFN-? on the proliferation of ESCs were determined using an MTS (a novel tetrazolium compound) assay. IFN-? treatment inhibited the proliferation of ESCs and decreased the weight of the fetus and placenta. These results indicate that exogenous IFN-? affects the expression of IL-1\u00df and inhibits ESC proliferation.<\/jats:p>","DOI":"10.1071\/rd06073","type":"journal-article","created":{"date-parts":[[2007,3,18]],"date-time":"2007-03-18T21:04:14Z","timestamp":1174251854000},"page":"510-519","source":"Crossref","is-referenced-by-count":3,"title":["Effect of interferon-? treatment on the expression of interleukin-1\u00df at the maternal\u2013fetal interface of pregnant rats"],"prefix":"10.1071","volume":"19","author":[{"given":"Hong-Fei","family":"Xia","sequence":"first","affiliation":[{"name":"AState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy Sciences, Beijing 100080, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan-Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"AState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy Sciences, Beijing 100080, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Pian","family":"Peng","sequence":"additional","affiliation":[{"name":"AState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy Sciences, Beijing 100080, China."},{"name":"BCorresponding author. Email: pengjp@ioz.ac.cn"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2007,3,19]]},"reference":[{"key":"2025102818344727600_R1"},{"key":"2025102818344727600_R2"},{"key":"2025102818344727600_R3"},{"key":"2025102818344727600_R4"},{"key":"2025102818344727600_R5"},{"key":"2025102818344727600_R6"},{"key":"2025102818344727600_R7"},{"key":"2025102818344727600_R8"},{"key":"2025102818344727600_R9"},{"key":"2025102818344727600_R10"},{"key":"2025102818344727600_R11"},{"key":"2025102818344727600_R12"},{"key":"2025102818344727600_R13"},{"key":"2025102818344727600_R14"},{"key":"2025102818344727600_R15"},{"key":"2025102818344727600_R16"},{"key":"2025102818344727600_R17"},{"key":"2025102818344727600_R18"},{"key":"2025102818344727600_R19"},{"key":"2025102818344727600_R20"},{"key":"2025102818344727600_R21"},{"key":"2025102818344727600_R22"},{"key":"2025102818344727600_R23"},{"key":"2025102818344727600_R24"},{"key":"2025102818344727600_R25"},{"key":"2025102818344727600_R26"},{"key":"2025102818344727600_R27"},{"key":"2025102818344727600_R28"},{"key":"2025102818344727600_R29"},{"key":"2025102818344727600_R30"},{"key":"2025102818344727600_R31"},{"key":"2025102818344727600_R32"},{"key":"2025102818344727600_R33"},{"key":"2025102818344727600_R34"},{"key":"2025102818344727600_R35"},{"key":"2025102818344727600_R36"},{"key":"2025102818344727600_R37"},{"key":"2025102818344727600_R38"},{"key":"2025102818344727600_R39"},{"key":"2025102818344727600_R40"},{"key":"2025102818344727600_R41"},{"key":"2025102818344727600_R42"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/19\/3\/510\/300885\/rd06073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/19\/3\/510\/300885\/rd06073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:34:51Z","timestamp":1761690891000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/19\/3\/510\/48465\/Effect-of-interferon-treatment-on-the-expression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,19]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3,19]]}},"URL":"https:\/\/doi.org\/10.1071\/rd06073","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"type":"print","value":"1031-3613"},{"type":"electronic","value":"1448-5990"}],"subject":[],"published":{"date-parts":[[2007,3,19]]}}}